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Cell . . . The latest and most comprehensive, Zhou Jianmin/ Zhang Yuelin system inventory plant immune perception and signal overview (worth collecting)
Time of Update: 2020-07-21
in addition, the review highlights recent breakthroughs in biosynthesis and perception of the major defense hormone salicylic acid (SA), which plays a key role in enhancing PRR and NLR mediated signal transduction.
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Treating rheumatoid arthritis, biologics benefit more from cardiovascular disease! EULAR 2020.
Time of Update: 2020-07-21
a multi center prospective observational clinical study (nor-dmard) from diakonhjoment hospital, Oslo, Norway, reported that remission of RA significantly reduced the incidence of CVD, and biological agents (bdmads) were more beneficial to CVD in patients with remission.
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Nature. The team of Single Libo/He Ping reveals new mechanisms for plant immunity regulation.
Time of Update: 2020-07-21
The induced monoubiquitination Bik1 directly affects the endocytosis process of fls2 cell membrane.
The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity.
Direct regulation of the NADPH oxidase RBOHD by the PRR-associated kinase BIK1 during plant immunity.
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Freshly baked! The 2020 ACR Gout Management Guide was officially announced, and non-bubs was downgraded to second-line medication! Guide sharing.
Time of Update: 2020-07-21
(level of evidence: high) ➤ for patients who have experienced more than one acute gout attack but are not frequent (< 2 times / year), it is conditional to recommend the initiation of ult treatment.
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The immune control of biological materials can reduce the rejection of implants.
Time of Update: 2020-07-21
We have used high-throughput screening technology to study how to design" immune indicator "surfaces based on the morphology and chemical properties of the materials In order to be used in implants, this will affect the function of macrophages and thus affect the response of foreign bodies to biomaterials.
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Science Latest Results: Isolated SARS-CoV-2 neutralizing antibodies to effectively protect animals against virus attacks!
Time of Update: 2020-07-21
obtaining pathogen neutralizing antibodies (nabs) of new coronavirus (sars-cov-2) may be a potential prevention and treatment option, which can also help guide vaccine design.
the results showed that the binding potency of donor plasma to sars-cov-2s protein changed greatly, but the potency to RBD decreased by an order of magnitude.
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Plant Cell. NLR receptors regulate the mechanism of plant immunity and drought response through EDS1/PAD4 signals.
Time of Update: 2020-07-21
interestingly, in addition to being involved in immune regulation, EDS1 / PAD4 and ADR1 (activated death resistance-like1, a kind of RNL) have also been proved to be involved in abiotic stress response of plants [4].
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Samples from malaria vaccine trials reveal the benchmark for immune measurement for conservation, Science translational medicine.
Time of Update: 2020-07-21
Click on the blue text above to focus on our research on samples from two independent clinical trials of malaria vaccines, Gemma moncunill and colleagues linked features in the immune system to improve vaccine protection for malaria in children and adults.
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New Phytt China University of Agriculture/French Academy of Agricultural Sciences reveals new mechanisms for root knot nematodes to suppress plant immune response.
Time of Update: 2020-07-21
Recently, Professor Jian Heng of China Agricultural University and Professor Pierre abad of Sophia Institute of agricultural biotechnology, French Academy of Agricultural Sciences, published the "root knot nematode effector mipdi1 targets a stress associated protein, SAP", To establish disease in Solanaceae and Arabidopsis "revealed the molecular mechanism of Meloidogyne incognita inhibiting plant immune response and enhancing its parasitism by secreting effector mipdi1.
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Cell Host and Microbe Guo Yahui, among others, reveal the body's congenital immune response to tobacco-cranked mold infections.
Time of Update: 2020-07-21
Fungal infection is an important cause of death in patients with low clinical immune function and deficiency. at present, the types of drugs that can be used to treat invasive fungal infections are
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Assessing the outcome of rheumatism and focusing on these indicators is right! EULAR 2020.
Time of Update: 2020-07-21
Professor Isabel castrejon from Madrid mentioned the following three points: to provide an objective explanation of the condition, and to compare the status of patients in two visits, and to help clinical decision-making.
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Nature. Notch3 is a key receptor for the differentiation and pathological development of rheumatoid arthritis fission membrane fibroblasts.
Time of Update: 2020-07-21
these results suggest that the positional identity of synovial fibroblasts is regulated by Notch signal from endothelial cells, and this signal interaction between stroma is the source of inflammation and pathological basis of inflammatory arthritis.
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Climb to the top again! The world's largest lupus nephritis III study was published. EULAR 2020.
Time of Update: 2020-07-21
Compared with the traditional treatment, baileyumab combined with standard therapy can significantly improve the renal response of patients with lupus nephritis, with good safety.
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Cell Research . . . The bell wave group found a new mechanism for antiviral immunity and autoimmune regulation.
Time of Update: 2020-07-21
the team found that usp29 interacts with CGAs continuously to remove ubiquitination modification of K48 link on CGAs and inhibit its degradation through proteasome pathway, thus promoting antiviral immune response and autoimmunity induced by TREX1 knockout.
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Cell: "Hijacking" the body's immune system, the new crown virus is very different from other viruses.
Time of Update: 2020-07-21
this unbalanced immune response means that in the early stage of infection, due to the lack of interferon expression, the replication of new coronavirus is not inhibited, resulting in the production of a large number of viruses.
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With AS to a fight, let the strong straight patient stand up the spine!
Time of Update: 2020-07-21
The treatment objectives of as mainly include the following four aspects: control of disease symptoms and inflammation degree, prevention of structural damage progress, maintenance of patients' function and social participation, and improvement of health-related quality of life [1,2].
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Based on clinical, focus on the forefront - fibromyalgia diagnosis and treatment of the big curry talk.
Time of Update: 2020-07-21
Jilin Provincial People's Hospital Wu Dasheng decided to move: two key points of fibromyalgia management and treatment of fibromyalgia clinical management: 1) positive - the diagnosis of FM is non exclusive diagnosis, for patients who meet the diagnostic criteria of FM, treatment should be actively initiated, without waiting for possible comorbidities or primary diseases to be identified before treatment.
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Repeated oral ulcers are "white plug disease"? Pay attention to this kind of identification!
Time of Update: 2020-07-21
according to the survey, oral ulcer was the first symptom of Behcet's disease, and it also had the highest proportion, up to 99.5% (98.3% in 2017); genital ulcer and skin damage accounted for 70.9% (70.8% in 2017) and 67.1% (62.8% in 2017), followed by joint pain, eye inflammation and other organs The official was damaged.
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New Phytol. | A new method of plant immune receptor cloning, rapidly locating immune receptors on plant membranes through RLP/RLK enrichment sequencing.
Time of Update: 2020-07-21
here, we developed a rapid method to identify and clone the immune receptors (RLP and RLK) on plant membrane using potato Phytophthora infestans as the model.
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Euro. Il-10 produced by B cells in neutralized mice can effectively fight hepatitis C virus infection.
Time of Update: 2020-07-21
Innovation point pan Qin and his collaborators found that targeting B10 cells specifically can reduce the virus titer in mice infected with hepatitis C virus, promote specific cell killing effect, and enhance the body's anti HCV infection effect.