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Victory over Adamu Single Resistance, again over Abassup, Abbvie continued to build on.
Time of Update: 2020-07-21
select PSA 1 is a multicenter, randomized, double-blind, parallel group, active and placebo-controlled clinical phase 3 study to evaluate the safety and efficacy of rinvoq?
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Cell: "Hijacking" the body's immune system, the new crown virus is very different from other viruses.
Time of Update: 2020-07-21
this unbalanced immune response means that in the early stage of infection, due to the lack of interferon expression, the replication of new coronavirus is not inhibited, resulting in the production of a large number of viruses.
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Nature: A major breakthrough! Chinese scientists have discovered for the first time that the central nervous system directly regulates the pathways of adaptive immunity, and that body behavior can enhance the immune response.
Time of Update: 2020-07-21
When the researchers used photogenetic methods to transform mice, the splenic nerve activation was observed after the CRH neurons were activated by light stimulation; moreover, the mice that used drugs to enhance the activity of CRH neurons also produced more splenic plasma cells after injection of antigens.
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Cancer Cell Highlights . . . "The gorgeous turn of antibody drugs" - autoimmune disease drugs into anti-cancer drugs.
Time of Update: 2020-07-21
among the CD40 targeted antibodies, the antagonistic IgG can prevent the binding of CD40L and CD40, so as to achieve the inhibition effect and reduce the autoimmune attack; the excited IgG can activate the CD40 signal pathway and increase the anti-cancer effect of the immune system.
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Nature. Notch3 is a key receptor for the differentiation and pathological development of rheumatoid arthritis fission membrane fibroblasts.
Time of Update: 2020-07-21
these results suggest that the positional identity of synovial fibroblasts is regulated by Notch signal from endothelial cells, and this signal interaction between stroma is the source of inflammation and pathological basis of inflammatory arthritis.
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With AS to a fight, let the strong straight patient stand up the spine!
Time of Update: 2020-07-21
The treatment objectives of as mainly include the following four aspects: control of disease symptoms and inflammation degree, prevention of structural damage progress, maintenance of patients' function and social participation, and improvement of health-related quality of life [1,2].
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The immune control of biological materials can reduce the rejection of implants.
Time of Update: 2020-07-21
We have used high-throughput screening technology to study how to design" immune indicator "surfaces based on the morphology and chemical properties of the materials In order to be used in implants, this will affect the function of macrophages and thus affect the response of foreign bodies to biomaterials.
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Nature. The team of Single Libo/He Ping reveals new mechanisms for plant immunity regulation.
Time of Update: 2020-07-21
The induced monoubiquitination Bik1 directly affects the endocytosis process of fls2 cell membrane.
The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity.
Direct regulation of the NADPH oxidase RBOHD by the PRR-associated kinase BIK1 during plant immunity.
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5 hot-spot studies to learn about the latest clinical developments in systemic lupus. EULAR 2020.
Time of Update: 2020-07-21
Dr. Dai Gao from the first hospital of Peking University, China, shared a real-world cohort study of lupus patients achieving low disease activity (lldas) and lupus remission definition (Doris, figure 2).
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Repeated oral ulcers are "white plug disease"? Pay attention to this kind of identification!
Time of Update: 2020-07-21
according to the survey, oral ulcer was the first symptom of Behcet's disease, and it also had the highest proportion, up to 99.5% (98.3% in 2017); genital ulcer and skin damage accounted for 70.9% (70.8% in 2017) and 67.1% (62.8% in 2017), followed by joint pain, eye inflammation and other organs The official was damaged.
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Climb to the top again! The world's largest lupus nephritis III study was published. EULAR 2020.
Time of Update: 2020-07-21
Compared with the traditional treatment, baileyumab combined with standard therapy can significantly improve the renal response of patients with lupus nephritis, with good safety.
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Samples from malaria vaccine trials reveal the benchmark for immune measurement for conservation, Science translational medicine.
Time of Update: 2020-07-21
Click on the blue text above to focus on our research on samples from two independent clinical trials of malaria vaccines, Gemma moncunill and colleagues linked features in the immune system to improve vaccine protection for malaria in children and adults.
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New Phytol. | A new method of plant immune receptor cloning, rapidly locating immune receptors on plant membranes through RLP/RLK enrichment sequencing.
Time of Update: 2020-07-21
here, we developed a rapid method to identify and clone the immune receptors (RLP and RLK) on plant membrane using potato Phytophthora infestans as the model.
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Based on clinical, focus on the forefront - fibromyalgia diagnosis and treatment of the big curry talk.
Time of Update: 2020-07-21
Jilin Provincial People's Hospital Wu Dasheng decided to move: two key points of fibromyalgia management and treatment of fibromyalgia clinical management: 1) positive - the diagnosis of FM is non exclusive diagnosis, for patients who meet the diagnostic criteria of FM, treatment should be actively initiated, without waiting for possible comorbidities or primary diseases to be identified before treatment.
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Cell Research . . . The bell wave group found a new mechanism for antiviral immunity and autoimmune regulation.
Time of Update: 2020-07-21
the team found that usp29 interacts with CGAs continuously to remove ubiquitination modification of K48 link on CGAs and inhibit its degradation through proteasome pathway, thus promoting antiviral immune response and autoimmunity induced by TREX1 knockout.
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Treating rheumatoid arthritis, biologics benefit more from cardiovascular disease! EULAR 2020.
Time of Update: 2020-07-21
a multi center prospective observational clinical study (nor-dmard) from diakonhjoment hospital, Oslo, Norway, reported that remission of RA significantly reduced the incidence of CVD, and biological agents (bdmads) were more beneficial to CVD in patients with remission.
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Science Advances paper-reading , engineered algae provide oxygen to tumors to enhance radiation therapy , and domestic goats gain immunity from wild relatives.
Time of Update: 2020-07-21
scanning two-dimensional code reading papers, the engineered microalgae implanted into the tumor tissue of mice significantly increased the oxygen level of the tumor and enhanced the efficacy of radiotherapy and phototherapy.
scanning two-dimensional code to read papers shows that despite the rapid rise in sea level, the Mississippi Delta swamp can survive.
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EULAR Jet News. Bellieus has made breakthrough progress in the field of children's SLE and lupus nephritis!
Time of Update: 2020-07-21
results showed that at 104 weeks, more patients in the "baileyumab + standard treatment group" reached the primary end point perR [43.0% vs.
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Freshly baked! The 2020 ACR Gout Management Guide was officially announced, and non-bubs was downgraded to second-line medication! Guide sharing.
Time of Update: 2020-07-21
(level of evidence: high) ➤ for patients who have experienced more than one acute gout attack but are not frequent (< 2 times / year), it is conditional to recommend the initiation of ult treatment.
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When systemic lupus encounter pregnancy, how to deal with the mother and child to ensure the safety of the mother and child?
Time of Update: 2020-07-21
in the latest edition of "2020 guidelines for diagnosis and treatment of systemic lupus erythematosus (hereinafter referred to as" the new guidelines "), the expert group also paid special attention to the management of SLE pregnancy, recommended the timing of pregnancy, multidisciplinary cooperation, close follow-up of mothers and infants, and the use of drugs for disease control.
