The immune control of biological materials can reduce the rejection of implants.

Author: Lauren introduction: biomaterials implanted in the human body will have effects and effects on local tissues and the whole body.mainly includes local tissue reaction and systemic immune response.implantable medical devices are limited by the foreign body reactions of the biomaterials that make them.this reaction can lead to chronic inflammation, tissue damage and fibrosis, leading to device rejection and failure.a team from the school of medicine and Life Sciences, University of Nottingham, recently found that the surface shape (topography) and chemical composition of polymer materials can be changed to produce materials that control the body's immune response.a team from the school of medicine and Life Sciences, University of Nottingham, found that the surface shape (topography) and chemical composition of polymer materials can be changed to produce materials that control the body's immune response.this may have future applications in the fight against rejection of medical devices including artificial joints, dental implants and vascular implants.the results of these two studies have recently been published in the journal advanced science and matter.artificial joints, scaffolds and dental implants are the most common devices that use biomaterials to restore function or completely replace diseased or damaged tissues.however, host reactions are common after biomaterial implantation, including some reactions such as inflammation, foreign body reaction (FBR) and fibrocystic development, which can lead to implant failure.these reactions are driven by the activation of immune cells called monocytes and macrophages attached to the graft surface.the physical properties of the surface of materials or implants known as "terrain" are known to affect macrophage adhesion.Amir, CO director of the study "We are studying how to create materials that can be safely placed in the body without the immune system attacking the human body and triggering rejection. To this end, we are exploring materials that can control the immune response. We have used high-throughput screening technology to study how to design" immune indicator "surfaces based on the morphology and chemical properties of the materials In order to be used in implants, this will affect the function of macrophages and thus affect the response of foreign bodies to biomaterials.schematic diagram of high-throughput screening method, which is used to identify hit polymers that promote the transformation of macrophage phenotype to pro-inflammatory or anti-inflammatory state in vitro and in vivo. The most advanced high-throughput screening method studied the relationship between the material appearance of 2176 different micrographs and the adhesion and behavior of immune cells.the results of this study show that the 5-10 micron diameter column is the key to drive the adhesion of phagocytes, and the density of micron sized columns is the key to control the immune response.the surface phenotype and adhesion of macrophages to the homopolymer array also found polymer chemicals with immune guidance function, which successfully controlled the immune response of preclinical rodent models.this is achieved by screening different polymer libraries and identifying materials that control macrophage behavior. artificial intelligence algorithms are used to simulate the relationship between material chemistry and the cellular reactions they produce. these results suggest that different immune guidance polymers attract different amounts of protein adsorption, which is the key to macrophage response. Gaima said: "these latest findings add to the large number of materials research being carried out at the University of Nottingham, and it is so exciting to find that these biomaterials may really change the rules of the game in the field of medical implants. using these materials in commercial products will be the ultimate goal of our study. "the study was conducted in collaboration with Eindhoven University of technology, the University of latrobey in Australia and the University of Maastricht. it is the next generation biomaterial discovery project funded by EPSRC program, aiming to discover new biomaterials. The aim is to enable researchers to customize materials identified as the best functional for specific applications beyond the limited range of polymer drugs and cell delivery agents currently licensed for use in humans and medical devices. Ref: [1] [2] recommended reading: fighting the epidemic situation, translational medicine network content team series report: the combination of gene mutation and alcohol drinking increases the risk of gastric cancer in East Asia [new discovery] sleep can aggravate allergic reaction, do you know? [Nature] obesity is related to intestinal flora disorder, statins are expected to treat intestinal flora disorder [new discovery] IL-4 is a potential new drug target for age-related macular degeneration