What are the commongines? What do I need to pay attention to when taking medication?

Inventory of hyperuricemia and gout treatment drugs and precautions! Hyperuricemia (Hua) is defined as two times of fasting blood uric acid more than 420 μ mol / L on different days, which is a metabolic syndrome caused by purine metabolism disorder.gout is a crystal associated arthropathy caused by monosodium urate deposition, which is directly related to hyperuricemia caused by purine metabolism disorder and / or reduced uric acid excretion. Gout can be manifested as acute or chronic gouty arthritis, gouty nephropathy, uric acid kidney stones, gout stones and hyperuricemia.the drugs for the treatment of hyperuricemia and gout are mainly the drugs for inhibiting the production of uric acid (allopurinol, febuxostat, etc.), promoting the excretion of uric acid (benzbromarone, etc.), uric acid oxidase (labilise, prekexil, pegolose), alkalizing urine drugs (sodium bicarbonate, citrate preparation), drugs for acute gout attack (non steroidal anti-inflammatory drugs, Qiushui) In addition, there was no significant difference between the two groups.in addition, patients with recurrent pain and refractory gout that can not be controlled by conventional drugs can be considered to use interleukin-1 antagonists, such as anabaectin, kanazumab and linacept.today, I will take you to check the commonly used hyperuricemia and gout treatment drugs for attention! Xanthine oxidase inhibitors (xoi), such as allopurinol and febuxostat, can inhibit uric acid synthesis.allopurinol only inhibited reduced xanthine oxidase, especially in patients with increased uric acid production; febuxostat had inhibitory effect on both oxidized and reduced xanthine oxidase, so the acid inhibition and acid lowering effects were more powerful and lasting, especially for patients with chronic renal insufficiency.Table 1 Benzbromarone can inhibit the active reabsorption of urate in renal tubules, increase the excretion of urate, and reduce the concentration of urate in the blood. It can alleviate or prevent the formation of urate crystals, reduce the injury of joints, and promote the formation of uric acid The dissolution of urate crystals.the 24-hour uric acid excretion has increased (> 3.54mmol) or urinary calculi are prohibited. Patients with ulcer disease or renal insufficiency should use it with caution.before and during the treatment, we should pay special attention to drinking more water and using drugs to alkalize urine.Table 2: commonly used drugs to promote the excretion of uric acid and precautions. The third class of uric acid oxidase drugs, such as labilise, prekexil and pegolose, can catalyze the oxidation of uric acid to allantoin with smaller molecular weight, higher water solubility and more soluble, and reduce the level of serum uric acid.Table 3 common uric acid oxidase drugs and their precautions class 4 alkalized urine drugs low pH urine (urine pH & lt; 6) is an important reason for the formation of uric acid kidney stones. Patients with kidney stones should keep the urine pH value between 6.2 and 6.9 at any time; 7 can increase the solubility of uric acid, but also increase the risk of calcium phosphate, calcium oxalate and calcium carbonate stone formation. It is recommended that the best pH value of morning urine for patients with hyperuricemia and gout is 6.2-6.9.in addition, the pH value of morning urine & lt; 6.0, especially when taking uric acid excretion drugs, it is recommended to use alkalized urine drugs such as sodium bicarbonate and citrate preparation to maintain the pH value between 6.2 and 6.9, which can reduce the risk of urinary acid renal calculi and facilitate the dissolution of uric acid renal calculi.sodium bicarbonate is suitable for patients with chronic renal insufficiency and metabolic acidosis; citrate preparation is suitable for patients with uric acid kidney stones, cystine stones and low citrate urine.Table 4 common alkalized urine drugs and their precautions type 5 anti-inflammatory and analgesic drugs such as colchicine, non steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids can quickly control the symptoms of arthritis and should be used as soon as possible (within 24 hours).first of all, small dose of colchicine or NSAIDs (sufficient dose and short course of treatment) is recommended. 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New pharmacology by Chen Xinqian [M]. Beijing: People's Health Press, Beijing, Chinese Journal of Endocrinology and metabolism, 2012,28: addendum 2a-1-32 first issue: Endocrinology channel of medical circles Author: Gao Lili reviewed: attending doctor Xu Naijia editor: Fenghe end love me, please give me a good look!