Breakthrough! Discover new SARS-CoV-2 antibodies that destroy the sting protein!

24, 2020 /PRNewswire/ -- Targeted stingproteins may provide an effective treatment for SARS-CoV-2 (COVID-19) and provide valuable structural data for the development of vaccines.
As part of a massive global scientific effort to find SARS-CoV-2 treatments or vaccines, Diamond Light Source, the UK's synchrotron, provides a team of researchers investigating the SARS-CoV-2 protein. Priority fast access? Permissions.
one of the teams just? The published results showed that the SARS antibody CR3022 neutralized SARS-CoV-2 by destroying the main sting protein.
their work shows that this antibody has therapeutic potential, either alone or in combination with other antibodies.
their high-resolution data will also provide valuable structural data for teams developing the SARS-CoV-2 vaccine.
the spur protein on SARS-CoV-2 has two functions during infection.
first, it is locked in a human cell, like two ring-linked puzzles.
second, the stinging protein undergoes a significant shape change that merges the cells and the outer membrane of the virus. The genetic material of
viruses can be easily transferred to human cells, where the virus can reproduce.
photo source: Diamond Light Source Ltd If the human immune system can produce antibodies that bind to the virus when it binds to human cells, they can neutralise the virus.
this antibody is called a receptor blocking antibody.
previously thought to be the only way to neutralise the virus with antibodies. "
This new study shows that CR3022 works in a completely different way," explains professor Dave Stuart, director of life sciences at Diamond and head of structural biology at the Department of Clinical Medicine at Oxford University.
use? eBIC's high-resolution cryogenic electron microscope allows the team to observe antibodies against the virus and determine their attack methods.
it completely destroys the stability of the stingprotein, neutralising the virus.
therefore, CR3022 is a collaborative antibody that can work alone or with receptor blocking antibodies.
," he continued, "this finding is particularly important in the antibody puzzle because the most common method of screening antibodies against SARS-CoV-2 does not examine this alternative method of attack."
further screening revealed more useful antibodies that were previously classified as ineffective.
these results may lead to antibodies used to treat SARS-CoV-2.
when human antibodies are produced in the body, they are relatively safe.
pharmaceutical companies can quickly replicate the required amount of antibodies.
", he added, one way the virus evades the immune system is to mutate so that the antibodies no longer work.
however, the hedgehog protein plays an important role in SARS-CoV-2, making it difficult to mutate.
makes it an ideal target for treatment and vaccines.
the team also used the diamond's beamline I03 for macromolecular crystallography (MX) scans? Hedgehog protein.
"The protein crystals we produce have high levels of solvents, which lead to weak x-ray scattering.
However, the high-resolution images we obtained with I03 provide us with high-quality data on the structure of viral proteins.
this information is critical because we may need to redesign the antibody to make it more effective.
" () References: Jiandong Huo et al. Neutralization of Destruction-CoV-2 by of the Prefusion Spike, Cell and Host and Microbe (2020). DOI: 10.1016/j.chom.2020.06.010.