Gout encountertheseative, medication will be more careful!

!---- hyperuric acid emis (HUA) refers to the normal diet of the normal, non-same-day two detection of fasting heurate (SUA) level sic,420 mol/L, female sgt; 360 ?mol/L, some of which HUA can be life-long without arthritis and other obvious symptoms, called asymptomatic HUA.gout genus metabolic rheumatism, is a crystal-correlated joint disease caused by monosodium urate (MSU) deposits in joints, directly related to THE CEA due to the metabolic disorder seditum disorder and/or decreased uric acid excretion.in addition to joint damage, gout can also be associated with kidney lesions and cardiovascular metabolic diseases such as hypertension, diabetes, hyperlipidemia, coronary heart disease, stroke moderate., what should be paid to treat disease-related drugs when using gout combined with cardiovascular metabolic disease? Uric acid-lowering uric acid drug non-cloth he is to inhibit uric acid synthetic drugs, clinically available for the treatment of HUA and gout, especially for chronic renal insufficiency, or if allopurinol allergy or HLA-B 5801 gene positive.it inhibits oxidizing and reductive jaundice oxidase, inhibits uric acid synthesis more powerfulthan phenopharyl, does not inhibit other enzymes involved in the synthesis and metabolism of radon and radon, and has a certain synergy to reduce the pressure.non-busta may cause an increased risk of death in gout patients with combined cardiovascular disease, although there is no conclusive, but for those with a history of cardiovascular disease, high risk factors or new cardiovascular disease, careful use and follow-up monitoring, alert to the occurrence of cardiovascular thrombosis events.the commonly used antihypertensive drugs in theantihypertensive drugs are the angiotensin conversion enzyme inhibitor (ACEI), angiotensin II receptor antagonists (ARB), calcium channel blockers (CCB), diuretics and beta blockers.among them ACEI, non-chlorate aRB, potassium diuretics, beta blockers can increase THE RELEASE of renal uric acid, and increase the risk of gout.▎ agiotensin II receptor antagonist (ARB) chloratan promotes uric acid excretion by inhibiting the activity of uric acid transporter 1 (URAT1), its uric acid reduction effect is dose-dependent, and by reducing blood uric acid levels to reduce cardiovascular events, can be used for gout or HUA combined hypertension . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .its uric acid-lowering effect is weak, the effect is not obvious can be used with other drugs.▎ dihydroquine-based calcium channel blockers (CCB) CCB such as nitrobenzene, ammonia chlorodipon, Sinitilevel can promote uric acid excretion, and can reduce the risk of gout attacks, and significantly reduce the risk of stroke in people with hypertension, can be used for gout or HUA combined ischemic stroke of hypertension.▎ diuretics, diuretics, diuretics can cause HUA, dose-dependent, and competitive inhibition of uric acid excretion, blood volume reduction caused by the increase in uric acid reabsorption, usually does not cause uric acid accumulation, but also rarely cause gout.but gout is disabled and used with caution in THE HUA or for people with a history of gout.sugar-lowering drugs are insulin, pancreatic glycemic peptide 1 (GLP-1) receptor agonists, biphenyls, sulforide drugs, grenai drugs, alpha-glycoside enzyme inhibitors (AGI), diazepam (TZDs), dithloride enzyme IV (DPP-4) inhibitors, sodium-glucosaride co-transporter 2 (SGLT2) inhibitors.due to insulin secretion can cause blood uric acid levels to increase, so gout or HUA as far as possible choose not to raise insulin levels of sugar-lowering drugs, such as bipherosis, AGI, TZDs, and sulfomia drugs, AGI, TZDs, SGLT2 inhibitors can reduce uric acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .in addition, insulin can promote re-absorption of renal near-end tube uric acid by activating URAT1, and gout combined with diabetes to increase blood uric acid levels. metformin has a uric acid-lowering effect. sulfomia can promote the excretion of uric acid and can be used for gout or HUA combined diabetics . . . 4-6, 8-10. alpha-glycoside enzyme inhibitor (AGI) acapoccosinath saccharine reduces the increase in blood uric acid levels due to sucrose decomposition. pyrethroids (TZDs) may reduce blood uric acid levels by reducing insulin resistance and can be used in gout or HUA combined diabetes. SGLT-2 inhibitors increase souracid discharge and reduce blood uric acid levels . . . 4-6, 8-10. lipid-lowering drugs are currently statins, cholesterol absorption inhibitors, beta drugs, antioxidant drugs (Probco), PCSK9 inhibitors and so on. atatrophatin can reduce blood uric acid levels by promoting renal uric acid excretion, combined WITH HUA's coronary heart disease secondary prevention can be used as a priority, but also for hypercholesterolemia or atherosclerosis combined with HUA patients .4-6, 8-10. The bat's drug non-Norbert inhibits reabsorption of near-end renal tube uric acid by inhibiting URAT1 and promotes renal uric acid excretion, which is slightly stronger than chlorhatan, and can be given priority for the combination of triglycerides in combination with HUA. antiplatelet drugs such as antiplatelet aspirin and tegrilol. aspirin is a cyclooxidase (COX)-1 inhibitor that inhibits thrombocytin A2 synthesis by irreversibly inhibiting platelets COX-1, and can be used as a basic and preferred drug for antiplatelet oral preparations. the effects of aspirin on uric acid metabolism are dose-specific: high doses (3g/d) can significantly inhibit the reabsorption of uric acid in the renal tube and promote uric acid excretion; taking into account the antiplatelet effects of small doses of aspirin and cerebrovascular benefits, it is not recommended to discontinue the combined HUA, so it is recommended to alkalinize urine, drink more water, and monitor the level of healytic acid. In addition, , the acute onset of gout should not be used aspirin, because it can inhibit the secretion of renal tube transport and cause uric acid retention in the kidneys; P2Y12 receptor antagonists inhibit platelet aggregation by interfering with platelet activation mediated by adenosine diphosphate (ADP). its usually mild and reversible degree of HUA, can make serum hypothalamus and jaundice rise, causing blood uric acid levels to rise; patients with previous HUA or gout arthritis are advised to use the digrine; References: (1) Practice Guide for Patients with Hyperuretic Emily/ Gout. (J) Chinese Journal of Internal Medicine, 2020, 59 (7): 519-527. 9(6): 421-426( China's Healthy Lifestyle Guide to the Prevention of Cardiovascular Metabolic Diseases.J., China Circulation Journal, 2020,35 (3): 209(4) China Guidelines for the Diagnosis and Treatment of Hyperuretic Siunate Sepsis (2019) Chinese Journal of Endocrine Metabolism, 2020, 36 (1): 1-13.5. Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Chinese Hyperuretic Senosis-Related Diseases (J.) Chinese Journal of Internal Medicine, 2017,56 (3:236-240) Pain Guidelines for primary diagnosis and treatment of wind and hyperuric acid (2019) (J) (J.) Chinese Journal of General Practitioners, 2020, 19 (4): 293-300 (2nd edition) 9,9/2017:28-107(8) Expert Consensus on the Combination of Hyperuretic Stoic Patients in China.J. Chinese Journal of Kidney Disease, 2017,33 (6:6:464-466) Chinese Kidney Disease Suric Acid Practice Guide to The Diagnosis and Treatment of Heemia (2017 edition) (2017 edition) (J) Chinese Medical Journal, 2017, 97 (25): 1928-1933. 013,29 (11): 913-918.11) Technical Specification for The Diagnosis and Treatment of Hyperuretic Acid Disorders After Kidney Transplantation in China (2019 Edition) (J. Organ Transplant, 2019, 10 (1): 10-13 Comprehensive Knowledge and Skills in Pharmacy (7th Edition) (7th Edition) (7th Edition) (M): Beijing: China Pharmaceutical Science and Technology Press, 2016:330-335.13 Chinese Expert Consensus on The Treatment of Hypertension in Diuretics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . :214-220(14) Guidelines for rational medication for the treatment of acute ST-section elevated myocardial infarction thrombosis (2nd edition) (2nd edition) (J) .J. China Frontier Journal, 2019,11 (11) 45-46.15." Comprehensive Knowledge and Skills of Pharmacy. Beijing: China Pharmaceutical Science and Technology Press, 2013:153.17 for Guerrero Clinical Application of China Expert Consensus .J. Chinese Journal of Cardiovascular Disease, 2016,44 (2:112-117 Corrie Source: End of the Endocrine Channel of the Medical Community- !-- Content Presentation - !-- To Determine Whether the End of The Login.