Sci Rep: A comparison of rheumatoid arthritis in the treatment of rheumatoids with a single drug called leflumit.
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Last Update: 2020-07-30
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Source: Internet
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Author: User
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!---- lefnometus (LEF) is a conventional synthetic disease-improving anti-rheumatoid drug (csDMARDs) for the treatment of rheumatoid arthritis.however, there were few studies comparing the efficacy of LEF single drug therapy with the efficacy of combining other csDMARDs.study assessed the efficacy and safety of LEF monodrug therapy (88 cases) and combination therapy (361 cases). After 3 months of, there were no significant differences in the activity scores of 28 joint diseases (DAS28), health assessment questionnaire (HAQ), blood sink (ESR) and C-reactive protein (CRP) in the single-drug treatment group and the combined treatment group (P.05).found that the two groups had similar response rates for DAS28 (P.gt;0.05) according to the European Union against Rheumatism (EULAR) response criteria., the two groups are similar in security.subgroup analysis found no difference in efficacy between the three combination therapies (LEF and methotrexate (MTX), LEF and hydroxychloroquine (HCQ) and LEF-MTX-HCQ).in addition, there was no significant difference between the efficacy of low dose s and high dose when the LEF dose was less than 40 mg/day.overall, these results show low doses of LE?? F single-drug therapy is not inferior to combination therapy..
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