Nature: Longitudinal analysis showed that patients with severe COVID-19 suffered from immune dysfunction.

28, 2020 // --- In a new study, researchers at Yale University in the United States found that the differential immune system responses of PATIENTs with COVID-19 help predict who will experience moderate and severe disease consequences.results may help identify high-risk patients early in the hospital.this finding may help identify people at high risk of severe illness early in hospital and recommend the use of medication for COVID-19.related findings were published online July 27, 2020 in the journal Nature, with the title "Longitudinal immuns revealo misin severe severe COVID-19".picture from NIAID-RML.the authors examined 113 patients admitted to Yale New Haven Hospital, affiliated with Yale University School of Medicine, and analyzed the different immune system responses they showed during their hospitalization, from admission to discharge or death.they found that in the early stages of the disease, all patients' immune system activities had a common COVID-19 "signature".However, in patients who experienced only moderate symptoms, the immune system responded less and the viral load decreased over time.patients who continue to develop into severe cases have not decreased in terms of viral load and immune system response, and many of their immune signals are accelerating.but even during early treatment, the authors found indicators that predict which patients have the greatest risk of serious illness. "We were able to identify signals indicating disease risk," said Akiko Iwasaki, apaper author and professor of immunology at Yale University School of Medicine."Scientists already know that in severe cases of COVID-19, the immune system releases a huge and destructive "cytokine storm.", however, the most important cause of damage in the immune system response is not clear.the authors' analysis found some interesting links to bad results., they say, is that one risk factor is the presence of alpha interferon, a cytokine that is mobilized to fight viral pathogens such as influenza viruses.However, patients with high levels of COVID-19 with high alpha interferon shones performed worse than those with low alpha interferon levels. "The virus doesn't seem to care about alpha interferon,"Iwasaki said. this cytokine seems to be harmful, not helpful. another early predictor of poor prognosis " is the activation of inflammatory body (inflammasome), a protein complex that detects pathogens and triggers inflammatory responses to infection. inflammatory body activation is associated with poor outcomes and death in some patients. the authors found that people who responded better to COVID-19 infection tended to express high levels of growth factor, a cytokine that repairs damage to blood vessels and tissue in the lining of the lungs. , these data can help predict high-risk patients with poor outcomes. they also said that drugs targeting specific inflammatory causes found in the study may help treat patients at risk of developing cases of severe COVID-19. (bioon.com) References: 1. Carolina Lucas et al. Longitudinal analyses revealo immun misfiring in severe COVID-19. Nature, 2020, doi: 10.1038/s41586-020-2588-y.2.Immune system system sque a man sque a coVID-19 outcomes.