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J Thromb Haemost: Incidence of venous thromboembolism in patients with COVID-19

 Time of Update: 2020-06-24

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2019 coronavirus disease (COVID-19) can lead to systemic clotting activation and complications of thrombosis In a recent study published in journal Sthrombosis and Haemostasis, an authoritative jour
Multiple myeloma in the case of the diagnosis of disease sedatives of the blood system

 Time of Update: 2020-06-24

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1 Case Thinking Map cases provided: Wang Wei, Wang Wei, Wang Hui II, bone marrow picture of the (1 ) (3) (4) (5) of the (5) (5) (6) (1) (2) (3) (4) 4, MM-relat
Blood: Macrophage Epo receptor signals promote red line differentiation during stress-forming

 Time of Update: 2020-06-24

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Center point: classic Wnt signal drives the proliferation of immature stress edifying red blood cells Epo signals in macrophages induce lipid media to promote stressed red blood cell progenitor
Blood: Prognosis for hematopoietic cell transplantation treatment for Wiskott-Aldrich syndrome

 Time of Update: 2020-06-24

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Aldridge syndrome (WAS) is an X-chromosome chain disease caused by mutations in the WAS gene that can lead to platelet reduction, eczema, recurrent infections, autoimmune diseases and malignant tumo
Brit J Heamatol: Primary prevention of venous thromboembolism in patients with multiple myeloma treated with immunomodulators

 Time of Update: 2020-06-24

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Immunomodulation drugs (IMiDs) improve survival in patients with multiple myeloma (MM) and are the cornerstone of treatment at all stages Despite good tolerance, IMiD can increase the incidence of v
Cell Death Dis：mPGES-1/PGE2/MTDH轴调控T-ALL细胞生长

 Time of Update: 2020-06-24

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Acute lymphoblastic leukemia is a highly heterogeneous aggressive hematologic malignancy that affects about one in every 100,000 adults Despite the very similar treatment strategies, The prognosis o
Blood: Transcription Factor ATF4 Activates BCL11A Transcription to Silent Fetal Hemoglobin Expression

 Time of Update: 2020-06-24

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Fetal hemoglobin reactivation remains a critical goal for the treatment of patients with sickle cell disease and beta-thalassemia Previous researchers have found that fetal gamma-globin gene silenci
Brit J Heamatol: Prevalence of non-anemia iron deficiency in the elderly and associated mortality

 Time of Update: 2020-06-24

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Iron is the core of many biological pathways, and in certain diseases, the treatment of non-anemia iron deficiency (NAID) is beneficial However, it is not clear whether NAID is associated with an in
Regenerative Element and Reding Pharmaceuticals develop REGN1979 (CD20xCD3 bispecific antibody) for the treatment of non-Hodgkin's lymphoma

 Time of Update: 2020-06-24

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Regeneron and Zai Lab announced a strategic partnership to develop and commercialize REGN1979 (CD20xCD3 dual-specific antibodies) in Chinese mainland, Hong Kong, Taiwan and Macau This partnership wi
Blood: Potential Mechanisms of Drug Induced Bleeding

 Time of Update: 2020-06-24

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Drug-induced bleeding leads to higher morbidity and mortality Antithrombotic drugs, which have obvious causes for accidental bleeding, are relatively easy to control But the mechanism of bleeding di
NEJM: Leva saban for venous thrombosis prevention after lower limb orthopaedic surgery

 Time of Update: 2020-06-24

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Non-major lower-body orthopaedic plastic surgery can lead to a brief decline in the patient's mobility, or even vein thromboembolism, and the prevention effect of delavsaban may be comparable to enn
Cell Death Dis: Ion Channel TRPM2 Promotes AML Cell Proliferation by Regulating Mitochondrial Function, ROS and Autophagy

 Time of Update: 2020-06-24

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The study found that levels of reactive oxygen (ROS) increased in acute myeloid leukemia (AML) Mitochondria are the main source of ROS, which damages tissue simply through protein oxidation, lipid p
Blood: GPS2 promotes red differentiation by regulating EKLF protein stability

 Time of Update: 2020-06-24

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Red blood cell production is a complex multi-stage process that involves early erythromycin differentiation to transnuclear mature red blood cells, in which their genealogy-specific transcription fa
Menarini targets drug tagraxofusp by acquisition of layout CD123

 Time of Update: 2020-06-24

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Italian drugmaker Menarini Group has announced the acquisition of Stemline Therapeutics for a of up to $677m and acquired the drug Elzonris, which targets CD123 CD123 is expressed in BPDCN and ma
EU approves Shionogi's new antibiotic Fetcroja for all KEY Gram-negative pathogens designated by THEA

 Time of Update: 2020-06-24

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Japan's Shionogi's antibiotic Fetcroja (cefiderocol) has been granted permission by the European Union to treat adult patients with a limited selection of Gram-negative bacterial infections approv
Blood: Ancient evolutionary mechanisms for gene expression of red blood cells in different species

 Time of Update: 2020-06-24

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The oxygen transport function of hemoglobin (HB) is thought to have occurred about 500 million years ago, roughly in line with the differentiation of inocyclic vertebrates (jawless) and jaw-based ve
China MNPA approves cell therapy GC007g for CD19 positive relapse difficult to treat B-cell acute lymphoblastic leukemia IND

 Time of Update: 2020-06-22

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Gracell, a clinical-phaseed cell and gene therapy company, recently announced that the National Drug Administration of China (NMPA) has approved the application of GC007g for a new research drug (IN
Blood: CalR single-dose insufficient to enhance the activity of hematopoietic stem cells, participation in MPN occurrence

 Time of Update: 2020-06-22

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The JAK2, MPL or CALR gene mutations are found in patients with more than 80% of myeloid hyperplasia tumors (MPNs) and are thought to play a driving role in THE MPN pathogenesis through autosomal ac
Blood: Researchers of normal and malignant hematopoietic stem cells OF SIRPA knock into model

 Time of Update: 2020-06-22

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In human-mouse xenotransplantation, the polymorphism of signal-regulating protein alpha (SIRPA) determines its binding affinity with human CD47, which is essential to the implantefficiency of human
Blood: MTOR activation enhancement for iexclusiveithasic multicenter Castleman disease

 Time of Update: 2020-06-22

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Iblast multicenter Castleman disease (iMCD) is a rare and incomprehensible blood disease characterized by lymph node disease, systemic inflammation, decreased blood cells, and multi-organ dysfunctio

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Blood System

J Thromb Haemost: Incidence of venous thromboembolism in patients with COVID-19

Multiple myeloma in the case of the diagnosis of disease sedatives of the blood system

Blood: Macrophage Epo receptor signals promote red line differentiation during stress-forming

Blood: Prognosis for hematopoietic cell transplantation treatment for Wiskott-Aldrich syndrome

Brit J Heamatol: Primary prevention of venous thromboembolism in patients with multiple myeloma treated with immunomodulators

Cell Death Dis：mPGES-1/PGE2/MTDH轴调控T-ALL细胞生长

Blood: Transcription Factor ATF4 Activates BCL11A Transcription to Silent Fetal Hemoglobin Expression

Brit J Heamatol: Prevalence of non-anemia iron deficiency in the elderly and associated mortality

Regenerative Element and Reding Pharmaceuticals develop REGN1979 (CD20xCD3 bispecific antibody) for the treatment of non-Hodgkin's lymphoma

Blood: Potential Mechanisms of Drug Induced Bleeding

NEJM: Leva saban for venous thrombosis prevention after lower limb orthopaedic surgery

Cell Death Dis: Ion Channel TRPM2 Promotes AML Cell Proliferation by Regulating Mitochondrial Function, ROS and Autophagy

Blood: GPS2 promotes red differentiation by regulating EKLF protein stability

Menarini targets drug tagraxofusp by acquisition of layout CD123

EU approves Shionogi's new antibiotic Fetcroja for all KEY Gram-negative pathogens designated by THEA

Blood: Ancient evolutionary mechanisms for gene expression of red blood cells in different species

China MNPA approves cell therapy GC007g for CD19 positive relapse difficult to treat B-cell acute lymphoblastic leukemia IND

Blood: CalR single-dose insufficient to enhance the activity of hematopoietic stem cells, participation in MPN occurrence

Blood: Researchers of normal and malignant hematopoietic stem cells OF SIRPA knock into model

Blood: MTOR activation enhancement for iexclusiveithasic multicenter Castleman disease