Brit J Heamatol: Prevalence of non-anemia iron deficiency in the elderly and associated mortality
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Last Update: 2020-06-24
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Source: Internet
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Author: User
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Iron is the core of many biological pathways, and in certain diseases, the treatment of non-anemia iron deficiency (NAID) is beneficialHowever, it is not clear whether NAID is associated with an increase in mortality among older people, researchers used a nationally representative sample of 4,451 older people from the Ukingr's Longitudinal Aging Study, in a study published in the journal British Journal of Blood System DiseasesNAID is defined as serum ferritin (30?g/l and hemoglobinThe researchers estimated cumulative mortality by kaplan-Meier method and used the Cox Proportional Risk Regression model to calculate the unadjusted and adjusted mortality risk ratio (HRs)baseline NAID prevalence was 8.8% (95% confidence interval (CI) 8.0-9.7%), female was 10.9% (95% CI 9.7-12.3%) and male s6.35 % (95% CI 5.3-7.5%)In 14 years of follow-up, NAID patients died in HR of 1.58 (95% CI was 1.29-1.93) compared to non-anemia patients with iron-free deficiencyThis association is independent of all known demographic indicators, health-related biological covariates, and is reliable in multisensitivity analysisit shows that NADis are common in older people in England and have an increased mortality rate compared to non-anemia individuals with normal serum ferritinThis correlation is mainly due to the high mortality rate among women
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