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Blood: Genetic variation of N-RasG12D palmylation affects hematogenesis and hinders myelin conversion
Time of Update: 2020-06-22
Note: Palmylized modification, is an important form of lipid modification after protein translation, is an important mechanism to regulate the transport, stability, positioning and function of prote
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Blood: MTOR activation enhancement for iexclusiveithasic multicenter Castleman disease
Time of Update: 2020-06-22
Iblast multicenter Castleman disease (iMCD) is a rare and incomprehensible blood disease characterized by lymph node disease, systemic inflammation, decreased blood cells, and multi-organ dysfunctio
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Blood: Venetoclax joint LDAC improves clinical prognosis in AML patients not suitable for intensive chemotherapy
Time of Update: 2020-06-22
For patients with acute myeloid leukemia (AML) who are unable to tolerate intensive chemotherapy, effective treatment options are limited This study is an international, randomized, double-blind,
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CAR-T Cell Immunotherapy (idecabagene vicleucel) for multiple myeloma
Time of Update: 2020-06-22
Bristol Myers Squibb and Bluebird Bio reported Tuesday (March 31, 2020) that they have filed a listing application with the FDA for ide-cel to treat relapsed refractory multiple myeloma, who have re
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CRISPR / Cas9 Therapy OTQ923 Treatment of Sickle Cell Disease: FDA Approves Clinical Trials
Time of Update: 2020-06-22
Intellia Therapeutics announced Tuesday (March 31, 2020) that the FDA has approved the initiation of A Phase I/II clinical studies based on CRISPR/Cas9 cell therapy OTQ923, which is used to treat si
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"Stocking up" On April 2, 2020 Blood Research Highlights
Time of Update: 2020-06-22
Rapid diagnosis of heparin-induced platelet reduction https://doi.org/10.1182/blood.2019002845 timely diagnosis of heparin-induced platelet reduction (HIT) is essential to guide the treatment
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Blood: Pre-treatment of genus Hodgkin's lymphoma for more than 20 years
Time of Update: 2020-06-22
Nodule lymphoblastation is a rare histological variant of Hodgkin's lymphoma (NLPHL), and the best treatment for Phase I-II NLPHL is uncertain Binkley et al conducted a multi-centered retrospective
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Blood: Increased CTCF occupancy in AML cells is associated with its abnormal expression genes
Time of Update: 2020-06-22
CTCF is the key regulatory factor for gene expression, and CTCF plays a role through tissue chromatin structure It is not clear how CTCF combinations are disturbed in leukemia or general cancer Muj
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Participate in Metz Medical Hypertension Emergency and Anticoagulant-related research and adjustment activities, win a good gift!
Time of Update: 2020-06-22
with economic growth and the continuous improvement of living standards, the incidence of cardiovascular diseasein in China shows a "one high one low" trend: high incidence, low age of patients (yo
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Blood: Aromatase is a new substrate of cereblon, involved in IMiDs induced platelet reduction
Time of Update: 2020-06-22
Immunomodulation drugs (IMiDs) are key drugs for the treatment of chromosomal 5q deficiency multiple myeloma and myeloma hyperplasia syndrome IMiD plays its multi-effect by raising new substrates to
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Cell joint agent AFM13 for T-cell lymphoma: approved by FDA Orphan Drug
Time of Update: 2020-06-22
Affimed, a clinical oncology treatment company, recently announced that the U.S Food and Drug Administration (FDA) has awarded AFM13, a cell joint used in combination with CD30 and CD16A, for the tr
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Cell Stem Cell: Inspiring! Newer and more effective stem cell transplantmethods could help blood cancer patients
Time of Update: 2020-06-22
Blood stem cells, also known as hematopoietic stem cells (HSC), produce every type of cell (red blood cells, white blood cells and platelets) in the blood and maintain blood production throughout li
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Annals of Oncology: "Research" Blood Test can detect a wide range of cancers that can be used in high-risk populations in clinical studies
Time of Update: 2020-06-22
A new blood test involving the upper hand detected more than 50 types of cancer, as well as their lesions in the body, with particularly high accuracy, according to an international team of research
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Summary of the 2020 J Clin Oncol Magazine Review (II)
Time of Update: 2020-06-22
J Clin Oncol: Should antioxidants be replenished during cancer chemotherapy? Despite reports of widespread use of dietary supplements during cancer treatment, there is little data on their safety o
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FDA approves Reblozyl treatment for anemia linked to myelogeny abnormal syndrome
Time of Update: 2020-06-22
Bristol Myers Squibb recently announced that the FDA has expanded the scope of reblozyl's indications to allow Reblozyl to treat anemia associated with low-risk myelogeny syndrome (MDS) The company
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NEJM: True universal no matching! Clinical studies showed that CAR-NK treatment had a total remission rate of 73%, and a donor cord blood could produce 100 copies of CAR-NK
Time of Update: 2020-06-22
In recent years, CAR-T therapy has been like entering deep water The odd dot saw either long-term efficacy data or the entry of a new pharmaceutical giant, a stunning new achievement that seems to h
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Blood: Integrated alpha6 mediated inthemtomemyle resistance
Time of Update: 2020-06-22
Resistance to multi-modal chemotherapy continues to limit the prognosis of acute lymphoblastic leukemia (ALL) Part of this occurs through a process known as adhesion-mediated resistance, which relie
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J Thromb Haemost: Anticoagulant therapy in patients with severe COVID-19 is associated with reduced mortality
Time of Update: 2020-06-22
The relatively high mortality rate for severe coronavirus disease (COVID-19) in 2019 is a cause for concern, and experts unanimously recommend the application of heparin in patients with COVID-19 du
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Collection: Highlights of Blood Research, March 26, 2020
Time of Update: 2020-06-21
The progression of MYC-driven lymphoma requires myC antagonist MNT to inhibit MYC-induced apoptosis https://doi.org/10.1182/blood.2019003014 myC overexpression disorders are associated with th