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Thorax: Lung Complications in Pregnant Women with Sickle Cell Disease
Time of Update: 2020-06-24
Sickle cell disease (SCD) is a multi-system disease characterized by the risk of vascular aphation, chronic anemia and short life span More and more SCD patients can live to the age of childbirth an
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Brit J Heamatol: Prevalence of non-anemia iron deficiency in the elderly and associated mortality
Time of Update: 2020-06-24
Iron is the core of many biological pathways, and in certain diseases, the treatment of non-anemia iron deficiency (NAID) is beneficial However, it is not clear whether NAID is associated with an in
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Circulation: PCSK9 inhibits effect soning of venous thromboembolism (VTE)
Time of Update: 2020-06-24
The relationship between cholesterol levels and the risk of venous thromboembolism (VTE) is uncertain The purpose of this study was to explore the effects and potential mechanisms of PCSK9 (type 9 p
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Brit J Heamatol: Acute kidney injury in children with sickle cell disease is related to disease and use of medical resources
Time of Update: 2020-06-24
Kidney disease is a common complication in patients with sickle cell disease (SCD), although the epidemiology of acute kidney injury (AKI) in pediatric patients and its effect on long-term kidney ou
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Blood: Potential Mechanisms of Drug Induced Bleeding
Time of Update: 2020-06-24
Drug-induced bleeding leads to higher morbidity and mortality Antithrombotic drugs, which have obvious causes for accidental bleeding, are relatively easy to control But the mechanism of bleeding di
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Blood:III Trial: Thrombosis in myeloma patients treated with different protocols
Time of Update: 2020-06-24
Newly diagnosed patients treated with immunomodulation drugs (IMiDs) have a higher risk of venous thrombosis (VTE), but there is no data from a large number of forward-looking queues This study is
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Blood: A new model that evaluates Emicizumab's functionality!
Time of Update: 2020-06-24
Bispecific antibody Emicizumab (Amyzumab) is increasingly used in the treatment of haemophilia Type A However, its specificity to human factors IX and X factor (FIX, FX) limited its invivia function
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Brit J Heamatol: Primary prevention of venous thromboembolism in patients with multiple myeloma treated with immunomodulators
Time of Update: 2020-06-24
Immunomodulation drugs (IMiDs) improve survival in patients with multiple myeloma (MM) and are the cornerstone of treatment at all stages Despite good tolerance, IMiD can increase the incidence of v
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Regenerative Element and Reding Pharmaceuticals develop REGN1979 (CD20xCD3 bispecific antibody) for the treatment of non-Hodgkin's lymphoma
Time of Update: 2020-06-24
Regeneron and Zai Lab announced a strategic partnership to develop and commercialize REGN1979 (CD20xCD3 dual-specific antibodies) in Chinese mainland, Hong Kong, Taiwan and Macau This partnership wi
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Blood: Macrophage Epo receptor signals promote red line differentiation during stress-forming
Time of Update: 2020-06-24
Center point: classic Wnt signal drives the proliferation of immature stress edifying red blood cells Epo signals in macrophages induce lipid media to promote stressed red blood cell progenitor
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Blood: SGLT2 inhibitor Ipalenet net successfully corrected neutrophil reduction and dysfunction of glucogen stored product Ib
Time of Update: 2020-06-24
Center Point: SGLT2 inhibitors improve Neutrophil Reduction/Neutrophil Dysfunction in GSD-Ib by reducing intracellular 1,5-aqueous glucose-6-phosphate Empagliflozin, used for the treatment of t
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Multiple myeloma in the case of the diagnosis of disease sedatives of the blood system
Time of Update: 2020-06-24
1 Case Thinking Map cases provided: Wang Wei, Wang Wei, Wang Hui II, bone marrow picture of the (1 ) (3) (4) (5) of the (5) (5) (6) (1) (2) (3) (4) 4, MM-relat
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1 case of hyperthermia-cold hemoglobinuria patients with peripheral blood smears of granulocytes and single-core cells
Time of Update: 2020-06-24
There are many reasons for swallowing blood cells in bone marrow morphological tests, and there are more types of cells that are swallowed However, the appearance of peripheral blood medium granuloc
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Blood: Transcription Factor ATF4 Activates BCL11A Transcription to Silent Fetal Hemoglobin Expression
Time of Update: 2020-06-24
Fetal hemoglobin reactivation remains a critical goal for the treatment of patients with sickle cell disease and beta-thalassemia Previous researchers have found that fetal gamma-globin gene silenci
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Focus on rare disease "thalassemia": FDA awards Mitapivat orphan drug title
Time of Update: 2020-06-24
Pharmaceutical company Agios announced today that the U.S Food and Drug Administration, the Administration of ( FDA ) has awarded acetone acid kinase-R (PKR) activator mitapivat for the treatment
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Cell Death Dis: Ion Channel TRPM2 Promotes AML Cell Proliferation by Regulating Mitochondrial Function, ROS and Autophagy
Time of Update: 2020-06-24
The study found that levels of reactive oxygen (ROS) increased in acute myeloid leukemia (AML) Mitochondria are the main source of ROS, which damages tissue simply through protein oxidation, lipid p
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Blood: Risk of bleeding in acquired haemophilia A (AHA) and response to hemostatic treatment
Time of Update: 2020-06-24
Acquired haemophilia A (AHA) is caused by autoantibodies of anticoagulant VIII (FVIII), usually accompanied by accidental bleeding Compared to congenital haemophilia, residual FVIII activity in pati
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Blood: Long-term prognosis for the treatment of acetaminotaminal co-phenyramstininin
Time of Update: 2020-06-24
Condensate disease (CAD) refers to autoimmune diseases characterized by the concentration of red blood cells in the blood vessels at the end of the limb, the occurrence of skin microcirculation diso
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Cell Death Dis:mPGES-1/PGE2/MTDH轴调控T-ALL细胞生长
Time of Update: 2020-06-24
Acute lymphoblastic leukemia is a highly heterogeneous aggressive hematologic malignancy that affects about one in every 100,000 adults Despite the very similar treatment strategies, The prognosis o
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Blood: Prognosis for hematopoietic cell transplantation treatment for Wiskott-Aldrich syndrome
Time of Update: 2020-06-24
Aldridge syndrome (WAS) is an X-chromosome chain disease caused by mutations in the WAS gene that can lead to platelet reduction, eczema, recurrent infections, autoimmune diseases and malignant tumo