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Focus on rare disease "thalassemia": FDA awards Mitapivat orphan drug title

 Time of Update: 2020-06-24

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Pharmaceutical company Agios announced today that the U.S Food and Drug Administration, the Administration of ( FDA ) has awarded acetone acid kinase-R (PKR) activator mitapivat for the treatment
Cell Death Dis：mPGES-1/PGE2/MTDH轴调控T-ALL细胞生长

 Time of Update: 2020-06-24

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Acute lymphoblastic leukemia is a highly heterogeneous aggressive hematologic malignancy that affects about one in every 100,000 adults Despite the very similar treatment strategies, The prognosis o
Blood:III Trial: Thrombosis in myeloma patients treated with different protocols

 Time of Update: 2020-06-24

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Newly diagnosed patients treated with immunomodulation drugs (IMiDs) have a higher risk of venous thrombosis (VTE), but there is no data from a large number of forward-looking queues This study is
Blood: In acute lymphoblastic leukemia, E2A-PBX1 is the secondary activation factor of RUNX1

 Time of Update: 2020-06-24

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E2A is a basic helix-ring-helix (bHLH) transcription factor that plays a vital role in determining the fate of tissue-specific cells, including B-cell spectral differentiation In 5% of children with
Blood: Risk of bleeding in acquired haemophilia A (AHA) and response to hemostatic treatment

 Time of Update: 2020-06-24

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Acquired haemophilia A (AHA) is caused by autoantibodies of anticoagulant VIII (FVIII), usually accompanied by accidental bleeding Compared to congenital haemophilia, residual FVIII activity in pati
Brit J Heamatol: Primary prevention of venous thromboembolism in patients with multiple myeloma treated with immunomodulators

 Time of Update: 2020-06-24

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Immunomodulation drugs (IMiDs) improve survival in patients with multiple myeloma (MM) and are the cornerstone of treatment at all stages Despite good tolerance, IMiD can increase the incidence of v
Brit J Heamatol: Statins and epoxy 2 inhibitors improve survival in patients with diffuse large B cell lymphoma

 Time of Update: 2020-06-24

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Preclinical data show that statins, metformin and epoxy-2 (COX-2) inhibitors have the potential to fight lymphoma In a recent study published in the journal British Journal of Haematology, researche
Thorax: Lung Complications in Pregnant Women with Sickle Cell Disease

 Time of Update: 2020-06-24

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Sickle cell disease (SCD) is a multi-system disease characterized by the risk of vascular aphation, chronic anemia and short life span More and more SCD patients can live to the age of childbirth an
Brit J Heamatol: Acute kidney injury in children with sickle cell disease is related to disease and use of medical resources

 Time of Update: 2020-06-24

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Kidney disease is a common complication in patients with sickle cell disease (SCD), although the epidemiology of acute kidney injury (AKI) in pediatric patients and its effect on long-term kidney ou
Blood: Prognosis for hematopoietic cell transplantation treatment for Wiskott-Aldrich syndrome

 Time of Update: 2020-06-24

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Aldridge syndrome (WAS) is an X-chromosome chain disease caused by mutations in the WAS gene that can lead to platelet reduction, eczema, recurrent infections, autoimmune diseases and malignant tumo
Blood: SGLT2 inhibitor Ipalenet net successfully corrected neutrophil reduction and dysfunction of glucogen stored product Ib

 Time of Update: 2020-06-24

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Center Point: SGLT2 inhibitors improve Neutrophil Reduction/Neutrophil Dysfunction in GSD-Ib by reducing intracellular 1,5-aqueous glucose-6-phosphate Empagliflozin, used for the treatment of t
J Thromb Haemost: Recurrent thrombosis in patients with antiphospholipid-positive venous or arterial thrombosis

 Time of Update: 2020-06-24

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Patients with positive antiphospholipid antibodies (aPL) and thromboembolism (TE) are at risk of TE recurrence However, few studies have been able to distinguish patients from initial events recen
J Thromb Haemost: Incidence of venous thromboembolism in patients with COVID-19

 Time of Update: 2020-06-24

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2019 coronavirus disease (COVID-19) can lead to systemic clotting activation and complications of thrombosis In a recent study published in journal Sthrombosis and Haemostasis, an authoritative jour
Menarini targets drug tagraxofusp by acquisition of layout CD123

 Time of Update: 2020-06-24

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Italian drugmaker Menarini Group has announced the acquisition of Stemline Therapeutics for a of up to $677m and acquired the drug Elzonris, which targets CD123 CD123 is expressed in BPDCN and ma
ULTOMIRIS (ravulizumab) treatment of atypical hemolytic uremia syndrome (aHUS): CHMP gives positive reviews

 Time of Update: 2020-06-24

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Alexion Pharmaceuticals recently announced that the European Medicines Agency's Human Drug Commission (CHMP) has taken a positive approach, recommending the EUROPEAN Union approval of ULTOMIRIS (rav
NEJM: Prevention of adverse prognosis for peripheral arterial disease in patients with peripheral artery disease used in vascular reconstruction

 Time of Update: 2020-06-24

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Recently, researchers examined the effect of Delavaban on the prevention of major adverse limb and cardiovascular events in patients with peripheral artery disease in the lower extremities patie
Blood: Transcription Factor ATF4 Activates BCL11A Transcription to Silent Fetal Hemoglobin Expression

 Time of Update: 2020-06-24

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Fetal hemoglobin reactivation remains a critical goal for the treatment of patients with sickle cell disease and beta-thalassemia Previous researchers have found that fetal gamma-globin gene silenci
Blood: EGFR-dependent DNA repair promotes blood regeneration

 Time of Update: 2020-06-24

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Chemotherapy and radiotherapy can cause DNA damage in hematopoietic stem cells (HSCs), leading to HSC depletion and dysfunction, and malignant transformation over time The external regulation of HSC
Blood: Macrophage Epo receptor signals promote red line differentiation during stress-forming

 Time of Update: 2020-06-24

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Center point: classic Wnt signal drives the proliferation of immature stress edifying red blood cells Epo signals in macrophages induce lipid media to promote stressed red blood cell progenitor
Multiple myeloma in the case of the diagnosis of disease sedatives of the blood system

 Time of Update: 2020-06-24

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1 Case Thinking Map cases provided: Wang Wei, Wang Wei, Wang Hui II, bone marrow picture of the (1 ) (3) (4) (5) of the (5) (5) (6) (1) (2) (3) (4) 4, MM-relat

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Blood System

Focus on rare disease "thalassemia": FDA awards Mitapivat orphan drug title

Cell Death Dis：mPGES-1/PGE2/MTDH轴调控T-ALL细胞生长

Blood:III Trial: Thrombosis in myeloma patients treated with different protocols

Blood: In acute lymphoblastic leukemia, E2A-PBX1 is the secondary activation factor of RUNX1

Blood: Risk of bleeding in acquired haemophilia A (AHA) and response to hemostatic treatment

Brit J Heamatol: Primary prevention of venous thromboembolism in patients with multiple myeloma treated with immunomodulators

Brit J Heamatol: Statins and epoxy 2 inhibitors improve survival in patients with diffuse large B cell lymphoma

Thorax: Lung Complications in Pregnant Women with Sickle Cell Disease

Brit J Heamatol: Acute kidney injury in children with sickle cell disease is related to disease and use of medical resources

Blood: Prognosis for hematopoietic cell transplantation treatment for Wiskott-Aldrich syndrome

Blood: SGLT2 inhibitor Ipalenet net successfully corrected neutrophil reduction and dysfunction of glucogen stored product Ib

J Thromb Haemost: Recurrent thrombosis in patients with antiphospholipid-positive venous or arterial thrombosis

J Thromb Haemost: Incidence of venous thromboembolism in patients with COVID-19

Menarini targets drug tagraxofusp by acquisition of layout CD123

ULTOMIRIS (ravulizumab) treatment of atypical hemolytic uremia syndrome (aHUS): CHMP gives positive reviews

NEJM: Prevention of adverse prognosis for peripheral arterial disease in patients with peripheral artery disease used in vascular reconstruction

Blood: Transcription Factor ATF4 Activates BCL11A Transcription to Silent Fetal Hemoglobin Expression

Blood: EGFR-dependent DNA repair promotes blood regeneration

Blood: Macrophage Epo receptor signals promote red line differentiation during stress-forming

Multiple myeloma in the case of the diagnosis of disease sedatives of the blood system