Blood: EGFR-dependent DNA repair promotes blood regeneration

Chemotherapy and radiotherapy can cause DNA damage in hematopoietic stem cells (HSCs), leading to HSC depletion and dysfunction, and malignant transformation over timeThe external regulation of HSC DNA repair is not yet completely clear, and the therapy for enhanced HSC DNA repair after bone marrow inhibition is not yet maturerecently, Fang et alhave discovered that epidermal growth factor receptors (EGFR) regulate THE DNA repair of HSC by activating DNA-dependent protein kinase-catalytic sub-cells (DNA-PKcs) and non-hoegen end connections (NHEJ)Blood regeneration in the body after systemic radiotherapy (TBI) depends on the repair of DNA damage mediated by EGF by activating DNA-PKcsconditional knockout of EGFR in hematopoietic dry/progenitor cells (HSPC) significantly reduces the activity of DNA-PKcs after radiotherapy, resulting in increased HSC DNA damage and inhibited HSC recoveryEGF promotes HSC DNA repair and rapid blood recovery in chemotherapy mice, with no effect on the growth of AML in the bodyin addition, EGF therapy can also promote the recovery of HSC in multispectral humans who can redifferentiate after radiation damagegenome-wide sequencing analysis showed that there was no increase in the coding region of HSPC in mice treated with EGF, but the number of copies between genes increased, the results of this study show that EGF promotes HSC DNA repair and blood-forming regeneration in the body by enhancing NHEJEGF has therapeutic potential to promote the regeneration of artificial blood cells, so further research is needed to assess their long-term hematopoietic effects