Blood: SGLT2 inhibitor Ipalenet net successfully corrected neutrophil reduction and dysfunction of glucogen stored product Ib

Center Point:SGLT2 inhibitors improve Neutrophil Reduction/Neutrophil Dysfunction in GSD-Ib by reducing intracellular 1,5-aqueous glucose-6-phosphateEmpagliflozin, used for the treatment of type 2 diabetes, can improve The neutrophil dysfunction of GSD-Ib without causing symptomatic hypoglycemiaSummary:neutrophil reduction and neutrophil dysfunction can cause severe infections and inflammatory bowel disease in patients with GSD-IbRecently, researchers found that in mouse models of G6PC3 defects and two rare diseases (GSD-Ib and G6PC30 deficiency), the accumulation of 1,5-aquethed glucose-6-phosphate led to a decrease in neutrophils, and thewide use of the widely used anti-diabetic drug Ipalenet (a renal glucose transportcosiol SGLT2 inhibitor) was used to treat GSD-Ib4 patients with GSD-Ib who were treated with granulocyte synod irritants (GCSF) for treatment without full remission, and within one month of ipane net therapy, serum 1,5-aqueous glucose and neutrophils 1,5-waterless glucose-6-phosphate levels were reducedin the clinic, frequent infection, mucous membrane lesions, inflammatory bowel disease symptoms are disappeared, and no symptoms of hypoglycemiaTwo patients were able to disable GCSF, and two others gradually reduced GCSF use by 57% and 81%, respectivelyThe number of neutrophils increased and stabilized in all patientsresearchers further confirmed that the function of neutrophils in patients improved: normal oxidation outbreaks (3/3), corrected protein glycosylation (2/2), and normal neutrophil aedionization (1/1) and bactericidal activity (1/1)in general, the anti-sugar drug ipalenet for type 2 diabetes has been successful in treating neutrophil reduction and neutrophil dysfunction of GSD-Ib, a rare genetic metabolic disease, without causing symptomatic hypoglycemiaThe researchers believe that neutrophils' function improved because of a lower concentration of 1,5-waterless glucose-6-phosphate in the cell