Multiple myeloma in the case of the diagnosis of disease sedatives of the blood system

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br/ br/ multiple myeloma (MM) is one of the most common types of plasma cell disease, also known as myeloma, plasma myeloma, or Kahler disease, It is characterized by the malignant proliferation of monoclonal plasma cells and the secretion of monoclonal immunoglobulins Normal polyclonal plasma cells and polyclonal immunoglobulin secretion are inhibited, resulting in extensive bone damage, recurrent infection, anemia, hypercalcemia, renal insufficiency and a series of clinical manifestations and lead to adverse consequences clinical manifestations 1, bone pain is one of the main symptoms of the disease, back pain is the most common, followed by chest ribs, limb bones less, shoulder jointand and limb joint pain less In addition to pain, pathological fractures can be seen 2, anemia and bleeding Anemia is another common clinical manifestation of this disease for myeloid anemia Bleeding is related to platelet reduction, platelets being covered by monoclonal globulin and clotting disorders 3, repeated infections The disease is prone to infection, polycoccal infection, can also have urinary system infection 4, kidney damage Renal lesions are more common and characteristic clinical manifestations, due to single-clone immunoglobulin and heavy chain and light chain synthesis out of balance, excessive light chain reabsorption caused by the damage of the renal tube Coupled with hypercalcemia, hyperuric acidemia, hypersticky emis, amyloid degeneration and tumor cell immersion, kidney damage can all cause 5 Hypercalcemia, bone damage, blood calcium increased Causes headaches, vomiting, lotion, and heavy deaths due to heart rate disorders and coma 6 High muscosal emis, hyperuric acid emis, nerve damage, amyloid degeneration and swollen liver and spleen diagnostic criteria 1, symptomatic MM diagnosis: (1) bone marrow primary plasma s 10% (or 15%), or /and biopsy to prove the appearance of plasma cell tumor; 2, atypical symptoms, but the following 1 or more abnormal indicators: (1) bone marrow raw plasma s60% ;( 2) serum free light chain ratio of 100; 3 Smoke-free MM diagnosis: (1) amyloid degeneration caused by no CRAB and plasma-free cell proliferation; (2) blood list clone M protein s 30g/L or urine M protein, 500mg/24h or myeloid primary plasma is 10% to 60% Zhang Jianfu Huang Xingqin and other sources: