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Daratumumab subcutaneous preparations for the treatment of multiple myeloma: CHMP takes a positive view

 Time of Update: 2020-06-24

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Genmab Pharmaceuticals today announced that the European Medicines Agency (EMA) Human Medicines Commission (CHMP) has issued a positive opinion on the use of daratumumab subcutaneous preparations fo
Blood: Full exome sequencing clears that the rare variation of STAB2 is closely related to VTE

 Time of Update: 2020-06-24

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Deep vein thrombosis and pulmonary embolism, collectively known as venous thromboembolism (VTE), are the third leading cause of cardiovascular disease death in the United States The Whole Genome Ass
FDA Grants Kymriah Advanced Treatment for Sefolioma Regenerative Medicine (RMAT)

 Time of Update: 2020-06-24

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Novartis today announced that the U.S Food and Drug Administration (FDA) has awarded Kymriah ® advanced regenerative medicine (RMAT) for treatment of recurrent lysopatomer (r/r) follicle-based lymph
Blood: Bleeding and thromboembolism risk and predictive markers in newly crowned virus-infected people

 Time of Update: 2020-06-24

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Increased D-dipolymer levels in patients with neo-coronavirus ( COVID-19 ) Early reports suggest that patients with new crown virus infection sedituated have a higher incidence of venous thrombo
Collection: Collection of Blood Research On April 23, 2020

 Time of Update: 2020-06-24

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THE BIVV001 is used for haemo philia a https://doi.org/10.1182/blood.2019001292 https://doi.org/10.1182/blood.2019001292 FVIII substitutes to provide comprehensive protection for haemophilia A
Blood: Extreme damage to heterogeneous colors accelerates aging of the hematopoietic system

 Time of Update: 2020-06-24

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Heterogeneous chromatin loss has long been considered a universal mechanism of aging of different species and different types of cells However, the comprehensive analysis of the changes in hematopoi
Blood: Plasma particles affect endothelial cells differently when patients with sickle cell disease have different effects on endothelial cells

 Time of Update: 2020-06-24

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Particles (MPs) are submicron extracellular vesicles that can be detected in large quantities in the blood circulation of patients with sickle cell anemia (SS) Several studies have studied the biolo
Blood: The role of the ECM-integrator receptor axis in the abnormal proliferation of primary bone marrow fibrosis macronuclear cells

 Time of Update: 2020-06-24

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Excessive accumulation of extracellular matrix (ECM) is a marker in primary bone marrow fibrosis (PMF) bone marrow (BM) environments Because cells have the ability to adhere to the surrounding ECM t
J Thromb Haemost: Recombinant human soluble thrombosis-regulated protein sepsis efficacy and safety in patients with sepsis-related clotting disorders

 Time of Update: 2020-06-24

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The efficacy and safety of the recombinant human soluble thrombosis-regulated protein (rhsTM) has not been clearly proven and its effects may depend on the presence or absence of sepsis-related clot
Brit J Heamatol: Homocysteine is associated with the severity of microvascular lesions in patients with sickle cell disease

 Time of Update: 2020-06-24

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The pathophysiological mechanisms of sickle cell disease (SCD) include vascular lesions and anemia Elevated plasma homocysteine is a risk factor for vascular disease and may be associated with an in
Lancet Haematol: Ibtinib Joint FCR for initial treatment of young CLL patients: a single arm, multicenter, Phase 2 clinical study

 Time of Update: 2020-06-24

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FCR programs consisting of fluoradarabin, cyclophosatine and rituximatosis can improve PFS in CLL patients with iGHV mutations in young (-65 years of age) chemotherapy tolerance However, patients wh
Blood: Open Conformation of ADAMTS13 - New Biomarkers of Subclinical iTTP

 Time of Update: 2020-06-24

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Recently, Roose et al found that adamTS13 circulated with open conformation altruism during the acute period of immune-mediated thrombocytopenia reduced cyanosis (iTTP) Although the cause of acute i
Blood: Anti-BMP6 antibody combined with EPO to treat chronic anemia!

 Time of Update: 2020-06-24

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Recombinant erythropoietin (EPO) and iron metabolites are standard treatments for anemia associated with chronic inflammation, including chronic nephrotic anemia A black box that warns of EPO therap
J Thromb Haemost: Relationship between platelet reduction and mortality in patients with COVID-19

 Time of Update: 2020-06-24

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Acute coronavirus 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome (SARS-CoV-2) is spreading rapidly worldwide Platelet reduction in patients with COVID-19 has not been fully analyzed Rec
NAT CELL BIO: Li's team develops an efficient cytosine editor

 Time of Update: 2020-06-24

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Cytosine base editor is a powerful genetic tool for catalyzing the conversion of cytosine to thoracic sine at a specific genomic site, and further improving editing scope and efficiency is essential
China NMPA approves first platelet reduction drug for adult patients with chronic liver disease - TPO agonisant DOPTE

 Time of Update: 2020-06-24

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AkaRx announced that its DOPTELET (Avatrombopag) has been approved by the State Drug Administration (NMPA) to treat platelet reduction in adult chronic liver disease (CLD) patients who plan to under
Blood: Long-term prognosis for children with malignant blood disease treated with HSCT

 Time of Update: 2020-06-24

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There are no prognosis statistics for patients who have reported a child hematopoietic stem cell transplant (HSCT) survivor In this study, Hsiu-Ju Yen and others compared the prevalence of symptoms
Blood: Heterogeneous mechanism of hemoglobin-induced expression in sickle cell disease and beta-thalassemia fetal hemoglobin

 Time of Update: 2020-06-24

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Reversing the switching development of hemoglobin from fetal hemoglobin (HbF, alpha2 x 2) to adult (HbA, alpha2 beta 2) is an important treatment for sickle cell disease (SCD) and beta-thalassemia I
NEJM: HLH-case reporting associated with diffuse TB

 Time of Update: 2020-06-24

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The patient was a 63-year-old man with chronic obstructive pulmonary disease (COPD) who went to the emergency department for fever, shortness of breath and confusion He had a six-month history of fa
Brit J Heamatol: Prevalence of non-anemia iron deficiency in the elderly and associated mortality

 Time of Update: 2020-06-24

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Iron is the core of many biological pathways, and in certain diseases, the treatment of non-anemia iron deficiency (NAID) is beneficial However, it is not clear whether NAID is associated with an in

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Blood System

Daratumumab subcutaneous preparations for the treatment of multiple myeloma: CHMP takes a positive view

Blood: Full exome sequencing clears that the rare variation of STAB2 is closely related to VTE

FDA Grants Kymriah Advanced Treatment for Sefolioma Regenerative Medicine (RMAT)

Blood: Bleeding and thromboembolism risk and predictive markers in newly crowned virus-infected people

Collection: Collection of Blood Research On April 23, 2020

Blood: Extreme damage to heterogeneous colors accelerates aging of the hematopoietic system

Blood: Plasma particles affect endothelial cells differently when patients with sickle cell disease have different effects on endothelial cells

Blood: The role of the ECM-integrator receptor axis in the abnormal proliferation of primary bone marrow fibrosis macronuclear cells

J Thromb Haemost: Recombinant human soluble thrombosis-regulated protein sepsis efficacy and safety in patients with sepsis-related clotting disorders

Brit J Heamatol: Homocysteine is associated with the severity of microvascular lesions in patients with sickle cell disease

Lancet Haematol: Ibtinib Joint FCR for initial treatment of young CLL patients: a single arm, multicenter, Phase 2 clinical study

Blood: Open Conformation of ADAMTS13 - New Biomarkers of Subclinical iTTP

Blood: Anti-BMP6 antibody combined with EPO to treat chronic anemia!

J Thromb Haemost: Relationship between platelet reduction and mortality in patients with COVID-19

NAT CELL BIO: Li's team develops an efficient cytosine editor

China NMPA approves first platelet reduction drug for adult patients with chronic liver disease - TPO agonisant DOPTE

Blood: Long-term prognosis for children with malignant blood disease treated with HSCT

Blood: Heterogeneous mechanism of hemoglobin-induced expression in sickle cell disease and beta-thalassemia fetal hemoglobin

NEJM: HLH-case reporting associated with diffuse TB

Brit J Heamatol: Prevalence of non-anemia iron deficiency in the elderly and associated mortality