Blood: Extreme damage to heterogeneous colors accelerates aging of the hematopoietic system

Heterogeneous chromatin loss has long been considered a universal mechanism of aging of different species and different types of cellsHowever, the comprehensive analysis of the changes in hematopoietic system caused by the loss of heterogeneous chromatin has yet to be studiedIn addition, the role of Suv39h1, the main heterocogenous chromatin methyl transferase, which has been reported in previous studies, is controversialIn the study, researchers described the causal effects of heterogeneous loss in the development of hematopoietic cells by performing unilateral or double knockremoval of Suv39h1 and Suv39h2 enzymesstudy found that the individual absences of Suv39h1 and Suv39h2 had no effect on the function of hematopoietic stem cells, lymphocytes, and myelin cellshowever, the simultaneous absence of both enzymes leads to characteristic changes associated with aging, such as decreased function of hematopoietic stem cells (HSCs), degeneration of the thymus and reduced lymphocyte outputThe decrease in lymphocyte output is manifested in the tendency to develop in the bone marrow, the reduction of initial T cells, and the increase of memory T cellsThese cell changes are accompanied by molecular changes consistent with the characteristics of aging, including changes in nuclear shape and larger nucleosomesthe results show that the hematopoietic system is significantly tolerant in the event of significant damage to chromatin structure, in addition to this study also revealed that Suv39h2 can be deposited enough H3K9me3 modification to protect the entire hematopoietic system from early aging-related changes