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Blood: Supplementing IL-2 improves prognosis in patients with ispecificatic aplastic anemia

 Time of Update: 2020-06-24

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Iexclusiveirerere anemia (AA) has two main characteristics: autoimmune response to hematopoietic stem cells/progenitor cells and regulatory Tregs defects Researchers have previously demonstrated a r
Zebutini, developed by Baiji Shenzhou, is listed in China today!

 Time of Update: 2020-06-24

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On June 3, The Baiji Shenzhou BTK inhibitor, The ® of Bacbane Zeitini ( generic name: Zebutini Capsules), was approved by the State Drug Administration to treat two adaptations in patients wit
CC-486 Treatment of Acute Myeloid Leukemia: FDA Grants Priority Review

 Time of Update: 2020-06-24

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Bristol Myers Squibb recently said the FDA has granted CC-486 priority review rights for the treatment of acute myeloid leukemia (AML) in adults The award was based on the results of the QuaZAR AML-
Pfizer TFPI antibody Marstacimab for haemophilia treatment, clinical trials to be held in China

 Time of Update: 2020-06-24

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On May 16, the Pfizer TFPI (Tissue Factor Pathway Inhibitor) antibody drug Marstacimab was declared clinically accepted by CDE Marstacimab is the first clinical TFPI antibody to be declared
Blood: Intestinal microbiome triamine N-oxide aggravates GVHD by inducing M1 macrophage polarization

 Time of Update: 2020-06-24

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The diversity of the human microbial community indicates the difference in the effects of intestinal microbial metabolites on allogeneic transplants for host disease (GVHD), although short-chain fat
JASN: Intravenous iron dose and risk of infection in hemodialysis patients

 Time of Update: 2020-06-24

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The results of experimental and observational studies have raised concerns that intravenous injections (IV) of iron in patients (e.g individuals receiving maintenance hemodialysis) may increase the
Blood: Predicting prognosis for abnormal hematopoietic function in patients with new myeloma

 Time of Update: 2020-06-24

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Center point: about 1/10 of myeloma patients showed MDS-related phenotype abnormalities at diagnosis and had poor survival MDS-related phenotype abnormalities alter the tumor microenvironment and
PI3K inhibitor umbralisib-CD20 inhibitor ublituximab for CLL trial was discontinued early due to significant efficacy

 Time of Update: 2020-06-24

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Chronic lymphocytic leukemia (chronic lymphocytic leukemia, CLL), chronic lymphocytic leukemia (chronic lymphocytic leukemia, CLL), an elderly disease characterized by the cloned proliferation of hi
JAMA Intern Med: Kramycin increases bleeding risk in senior DOAC populations

 Time of Update: 2020-06-24

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Kramycin is a common antibiotic that increases the concentration of blood medicine simply oral anticoagulants (DOACs) and increases the risk of bleeding Recently, researchers compared the effects
FDA approves IND application for BCL-2 oral selective inhibitor ZN-d5 for treatment of malignant tumors in the hematologic system

 Time of Update: 2020-06-24

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Zentalis Pharmaceuticals announced that its application for a new research drug (IND) targeting BCL-2, an oral selective inhibitor, ZN-d5, has been approved by the U.S Food and Drug Administration (
"Stocking up" On April 9, 2020 Blood Research Select

 Time of Update: 2020-06-24

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The difference in the immune spectrum between chronic GvHD and advanced acute GvHD https://doi.org/10.1182/blood.2019003186 3 months after hematopoietic stem cell transplantation (HSCT), huma
Gastroenterology: Pancreatic catheter adenocarcinoma needs to be alert to venous thrombosis

 Time of Update: 2020-06-24

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Statistics found that the incidence of vein thromboembolism (VTE) was highest in patients with pancreatic catheter adenocarcinoma (PDAC) However, the risk factors and prognosis of VTE in PDAC patien
Circulation: Potential relationship between white blood cell count levels and blood pressure!

 Time of Update: 2020-06-24

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Hypertension (BP) is a risk factor for cardiovascular disease incidence and mortality Although blood pressure is regulated by renal function, blood vessels and the sympathetic nervous system, recent
Blood: Predictive model of initial treatment in early CLL patients

 Time of Update: 2020-06-24

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Most patients with chronic lymphoblastic leukemia (CLL) are diagnosed at an early stage of the disease and treated under active monitoring The individual course of early CLL patients is heterogeneou
Gene therapy Valoctocogene Roxaparvovec For Severe Haemophilia A: Long-term Data Again Validates Effectiveness and Safety

 Time of Update: 2020-06-24

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BioMarin Pharmaceuticals recently announced that the gene therapy Valoctocogene Roxaparvovec for the treatment of severe haemophilia A's Open Label I/II study has yielded new results to be announced
Brit J Heamatol: Immune platelet reduction effects on child fatigue, executive function and psychology

 Time of Update: 2020-06-24

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Immune platelet reduction (ITP) in children is generally considered a relatively light blood disease, and only a few patients need treatment for painful bleeding In recent years, the disease has bee
Blood: Transcription Factor ETS1 Regulates NK Cell Development and End-End Differentiation

 Time of Update: 2020-06-24

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Center point: people's LACK of ETS1 inhibits the expression of several NK cell-related key transcription factors and NK cell differentiation ETS1 is essential for tumor cell induced NK cytotoxici
Blood: High-throughput sequencing of immunoglobulin variable domainreveals reveals specific mutation map of POEMS syndrome

 Time of Update: 2020-06-24

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POEMS syndrome is a rare multi-system disease caused by plasma cell (PC) disorder the pathophysiological physiology of the disease remains However, the role of monoclonal immunoglobulin (Ig) light
Blood: MDH1 mediated malic acid-tinline NADH cycle maintains fetal liver HSC activity

 Time of Update: 2020-06-24

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The relationship between the energy metabolism and dryness of hematopoietic stem cells (HSCs) at different stages of development is largely unclear In this study, Hao and others established a genet
1 case of Philadelphia chromosome after relapse of chromosomal negative acute myeloid leukemia in Philadelphia

 Time of Update: 2020-06-24

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Blood System

Blood: Supplementing IL-2 improves prognosis in patients with ispecificatic aplastic anemia

Zebutini, developed by Baiji Shenzhou, is listed in China today!

CC-486 Treatment of Acute Myeloid Leukemia: FDA Grants Priority Review

Pfizer TFPI antibody Marstacimab for haemophilia treatment, clinical trials to be held in China

Blood: Intestinal microbiome triamine N-oxide aggravates GVHD by inducing M1 macrophage polarization

JASN: Intravenous iron dose and risk of infection in hemodialysis patients

Blood: Predicting prognosis for abnormal hematopoietic function in patients with new myeloma

PI3K inhibitor umbralisib-CD20 inhibitor ublituximab for CLL trial was discontinued early due to significant efficacy

JAMA Intern Med: Kramycin increases bleeding risk in senior DOAC populations

FDA approves IND application for BCL-2 oral selective inhibitor ZN-d5 for treatment of malignant tumors in the hematologic system

"Stocking up" On April 9, 2020 Blood Research Select

Gastroenterology: Pancreatic catheter adenocarcinoma needs to be alert to venous thrombosis

Circulation: Potential relationship between white blood cell count levels and blood pressure!

Blood: Predictive model of initial treatment in early CLL patients

Gene therapy Valoctocogene Roxaparvovec For Severe Haemophilia A: Long-term Data Again Validates Effectiveness and Safety

Brit J Heamatol: Immune platelet reduction effects on child fatigue, executive function and psychology

Blood: Transcription Factor ETS1 Regulates NK Cell Development and End-End Differentiation

Blood: High-throughput sequencing of immunoglobulin variable domainreveals reveals specific mutation map of POEMS syndrome

Blood: MDH1 mediated malic acid-tinline NADH cycle maintains fetal liver HSC activity

1 case of Philadelphia chromosome after relapse of chromosomal negative acute myeloid leukemia in Philadelphia