Blood: Integrated alpha6 mediated inthemtomemyle resistance
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Last Update: 2020-06-22
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Source: Internet
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Author: User
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Resistance to multi-modal chemotherapy continues to limit the prognosis of acute lymphoblastic leukemia (ALL)Part of this occurs through a process known as adhesion-mediated resistance, which relies on ALL cells to adhere to the matrix through adhesion molecules, including integratorsthe integration protein alpha6 is associated with the migration of small residual lesions in ALL and ALL cells to the central nervous systemHowever, no studies have yet been conducted to assess it in the context of chemotherapy resistancein this study, researchers found that the anti-human alpha6 blocking antibody P5G10 can induce primary ALL cell apoptosis in vitro and can make primary ALL cells sensitive to chemotherapy or tyrosine kinase inhibition outside the bodyresearchers further analyzed the potential mechanism of alpha6-associated apoptosis by conditional knockout of alpha6 of bCR-ABL1 plus B-ALL cells in mice, and found that alpha6-ischemic ALL cells developed apoptosisKnocking out alpha 6 in the body, coupled with tyrosine kinase inhibitors (TKI) therapy, is more effective at removing ALL cells than using TKI (Nirotini) treatment aloneproteomics analysis showed that the loss of alpha 6 in all cells in mice was associated with changes in Src signals, including phosphorylation of Lyn (pTyr507) and Fyn (pTyr530), the refore, the data in this study suggest that alpha 6 may be a new therapeutic target for ALL
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