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Break through the mucus barrier and take large protein drugs orally
Time of Update: 2022-10-14
"By replacing mucus, we can maximize the dispersion of the drug in local areas and enhance the absorption of small and large molecules," said Giovanni Traverso, Karl van Tassel Career Development Assistant Professor of Mechanical Engineering at MIT and gastroenterologist at Brigham Women's Hospital.
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The Chen Haifeng Research Group of Shanghai Jiaotong University published the latest research results on the molecular force field of nucleic acids
Time of Update: 2022-10-14
Recently, the internationally renowned journal International Journal of Biological Macromolecules published the latest research results of Professor Chen Haifeng's research group of Shanghai Jiaotong University entitled "Base-Specific RNA Force Field Improving the Dynamics Conformation of Nucleotide" 。 This study proposes a base-specific RNA molecular force field (BSFF1), which effectively improves the simulation effect against nucleic acids.
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"Transitory peptide" in vivo delivery of Cre recombinase into mouse central nervous cell transduction efficiency ≥ AAV transduction!
Time of Update: 2022-10-14
summarySimple co-injection of Cre recombinase with HIV-TAT peptide successfully delivered Cre to mouse nerve cells, and Cre's delivery successfully activated the expression of reporter genes in neurons and astrocytes in the cerebral cortex without causing tissue damage, and its transduction efficiency was comparable or better than that of commonly used adeno-associated viruses.
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This group of molecules can extend life expectancy and health
Time of Update: 2022-10-14
elegans and protect human cells against oxidative damage Globally, life expectancy has increased due to advances in health and technology, but improvements in living standards for the elderly have lagged far behind.
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Nature's "junk DNA" is broken, and scientists have a new understanding of neurological diseases
Time of Update: 2022-10-14
Nature, 2022; 609 (7929): 1038 Scientists have found that the breaking and repair of "junk" DNA affects our protection against neurological disorders, so it may open up new avenues for the treatment of neurological diseases.
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The Science sub-journal emphasizes the importance of temperature: a surprising link between circadian rhythm disorders and cancer
Time of Update: 2022-10-14
essayCircadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer Picture: Mice under "chronic jet lag" (CJL) conditions had a 68% increase in tumor burden compared to mice placed under 12 h light and 12 h dark (12:12 LD).
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Single-cell studies point to the role of DNA methylation in cell fate decisions
Time of Update: 2022-10-14
At the time of the study, Dr. Stephen Clark, a senior researcher in Reik's lab, said: "The use of single-cell methods has indeed provided us with the resolution needed to study the mechanisms of DNA methylation during development.
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Biosensors can detect brain tumors with less than a drop of blood
Time of Update: 2022-10-14
DEEP Surveillance of Brain Cancer Using Self-Functionalized 3D Nanoprobes for Noninvasive Liquid Biopsy According to the National Cancer Institute, despite significant progress, the death rate from brain tumors remains high, with a 5-year survival rate of 36 percent.
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A deeper understanding of addiction recovery
Time of Update: 2022-10-14
Warren Bickel, a professor at the Fralin Institute for Biomedical Research, is working to provide a scientific understanding of rehabilitation and relapse with the help of a new grant from the National Institutes of Health.
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Shanghai Jiaotong University School of Medicine: The pancreas has an autonomous biological clock Restart pancreatic clock therapy is expected as a treatment strategy
Time of Update: 2022-10-14
Using a combination of melatonin and the Rolla agonist SR1078, which improves the circadian rhythm stabilization ring by pharmacology, thereby mitigating intrapancreatic pathological changes in a mouse model of CP,this study identified the protective effect of the pancreatic circadian clock on pancreatic fibrosis and exocrine dysfunction.
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Cell-free DNA for low-cost early cancer detection
Time of Update: 2022-10-14
The UCLA-led Johnson Comprehensive Cancer Center led the study to test a cost-effective way to detect early cancer from cells in blood samples.
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Nature Sub-Issue: New Automated Early Idiopathic Pulmonary Fibrosis Screening Tool
Time of Update: 2022-10-14
According to researchers from Will Cornell Medical School, New York Presbyterian Hospital, the University of Chicago, Brigham Women's Hospital, and the Mayo Clinic, a new electronic medical record screening tool can accurately identify high-risk patients with or develop progressive lung scarring, a condition known as idiopathic pulmonary fibrosis.
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Chinese scholars and overseas collaborators have made progress in molecular motor research
Time of Update: 2022-10-14
: 21971267), Professor Depeng Zhao and collaborator Ben Feringa of Sun Yat-sen University reported that the use of chemical energy to drive molecular motors to achieve high unidirectional continuous rotation.
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Science Advances' new view: Obesity is a neurodevelopmental disorder
Time of Update: 2022-10-14
”Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index In recent decades, the number of obese people has increased rapidly, affecting more than 2 billion people, making it one of the biggest causes of poor health worldwide.
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PNAS describes for the first time the underlying mechanism by which drugs increase brown fat in adults
Time of Update: 2022-10-14
This study describes for the first time a drug-based approach to increasing the quality of brown adipose tissue (BAT) adult animals.
This study describes for the first time a drug-based approach to increasing the quality of brown adipose tissue (BAT) adult animals.
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Where do PNAS stem cells go wrong and develop into cancer cells?
Time of Update: 2022-10-14
In studying the stem cell differentiation pathway, researchers at the University of California, Santa Barbara, found that all the proteins involved did not form assembly lines or rigid structures, but combined into a single droplet.
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Nature reshapes mitochondria to affect the immune system
Time of Update: 2022-10-14
A new study of immune system Th17 cells suggests that the shape and function of their mitochondria (the dynamics of cells) are important in autoimmune and inflammatory diseases such as multiple sclerosis.
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Chinese scholars have made progress in the construction of light/cobalt synergistic catalytic axial chirality
Time of Update: 2022-10-14
This study not only provides a new idea for the asymmetric radical coupling reaction catalyzed by light/cobalt collaboration, but also provides a new method for the preparation of axial chiral heteroaryl skeleton and related functional materials.
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Nature opens up a whole new field of research into "junk" DNA – the rupture of "junk" DNA leads to new insights into neurological diseases
Time of Update: 2022-10-14
A new study has identified how oxidative disruption is formed and repaired in what scientists consider "junk" DNAThe study also found that fixing these breaks plays a vital role in protecting us from
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Chenzhu Wang's research team revealed that the deletion of the Orco gene led to severe olfactory dysfunction of the important agricultural pest cotton bollworm
Time of Update: 2022-10-14
Deletion of the Orco gene leads to olfactory dysfunction produced by bollworms Insects live in a complex and changeable environment with various odors, so the sense of smell is essential for their life activities.
