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eLife's newly discovered protein could be used to produce life-saving antifungal drugs
Time of Update: 2022-10-14
If scientists develop drugs that inhibit the growth of disease-causing yeast by controlling TORC1, Capaldi said, "we're going to be in big trouble, because TORC1 also controls the growth of human immune cells and so on.
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【Research Trends】Ma Cong's research group reveals the molecular mechanism of Rabphilin 3A regulating cytosis secretion in neuroendocrine cells
Time of Update: 2022-10-14
On September 29, 2022, Professor Ma Cong's research group of the School of Life Sciences and Technology of Huazhong University of Science and Technology published a research paper entitled "Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis" in eLife, an authoritative journal in the field of biology.
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The Institute of Zoology collaborative team revealed the domestication mechanism of mouse behavioral and neural genes
Time of Update: 2022-10-14
Genome Biology） Experimental mice are one of the most commonly used mammalian models in biological and medical research, derived from long-term domestication of wild house mice.
Genome Biology） Experimental mice are one of the most commonly used mammalian models in biological and medical research, derived from long-term domestication of wild house mice.
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KIR-based inhibition of CARs overcame CAR-NK cell division-mediated cannibalism and tumor escape
Time of Update: 2022-10-14
KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape Trogocytosis is an active process that transfers surface material from target cells to effector cells.
KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape Trogocytosis is an active process that transfers surface material from target cells to effector cells.
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Nanyang Polytechnic in Singapore mapped electron microscopy of the molecular structure of chromosome telomeres DNA
Time of Update: 2022-10-14
In addition to deepening understanding of how telomeres are involved in processes such as aging and DNA damage, the findings of the Nanyang Technological University research team may also help develop potential treatments for diseases caused by telomere dysfunction.
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Nature A new hope for people with depression: powerful long-acting antidepressants
Time of Update: 2022-10-14
Although it has been known for decades that 5HT2a receptors activate different signaling pathways in cells, until now there have been no compounds that are selective enough to observe the effects of each pathway.
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Nature: Can it create a "non-psychedelic" compound that is not hallucinogenic but has antidepressant effects
Time of Update: 2022-10-14
Figure: Representation of serotonin-2A receptor (5HT2AR) signaling protein complex binding to the new compound R-69 (magenta subset) Image credit: Ross Lab, University of North Carolina School of MedicineAlthough recreational use is illegal, psychedelics show great promise as drugs for treating severe depression and anxiety, alcohol addiction, and other ailments.
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Learn about virtual memory CD8+ T cells
Time of Update: 2022-10-14
virtual machinesMaria Cecillia Rodriguez-Galan Universidad Nacional de Córdoba and his collaborators reviewed the biology and development of innate memory (TIM/TVM) cells.
"recent"The memory of most immune T cells is trained by exposure to antigens provided by invading pathogens.
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Inject protein into the brain to toggle the switch of spinal cord repair
Time of Update: 2022-10-14
"We found that we could successfully deliver a protein into the brains of mice," said Dr. Jean-Philippe Pellois, a professor and associate director of the Department of Biochemistry and Biophysics in the College of Agriculture and Life Sciences at Texas A&M University.
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Renal macrophages have different subsets and occupy different microenvironments
Time of Update: 2022-10-14
Now, Dr. James George of the University of Alabama at Birmingham and his colleagues report for the first time that mouse kidneys contain seven different KRM populations, which are located in a spatially discrete microenvironment, and that each subpopulation has a unique transcriptome signature — a measure of which genes are active, suggesting that they have different functions.
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Uncover the unique evolutionary path of CRISPR guardian RNA
Time of Update: 2022-10-14
1093/nar/gkac712/6677323 The Xiang Hua/Li Ming research team at the Institute of Microbiology of the Chinese Academy of Sciences previously discovered a new class of double-RNA toxin-antitoxin system CreTA (Science, 2021) that can guard CRISPR-Cas, and further research found that CreTA originated from the mini-CRISPR structure, but its repeat sequence repeat was highly degraded (Nucleic Acids Res, 2021).
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Where do PNAS stem cells go wrong and develop into cancer cells?
Time of Update: 2022-10-14
In studying the stem cell differentiation pathway, researchers at the University of California, Santa Barbara, found that all the proteins involved did not form assembly lines or rigid structures, but combined into a single droplet.
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Cell-free DNA for low-cost early cancer detection
Time of Update: 2022-10-14
The UCLA-led Johnson Comprehensive Cancer Center led the study to test a cost-effective way to detect early cancer from cells in blood samples.
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Nature Sub-Issue: New Automated Early Idiopathic Pulmonary Fibrosis Screening Tool
Time of Update: 2022-10-14
According to researchers from Will Cornell Medical School, New York Presbyterian Hospital, the University of Chicago, Brigham Women's Hospital, and the Mayo Clinic, a new electronic medical record screening tool can accurately identify high-risk patients with or develop progressive lung scarring, a condition known as idiopathic pulmonary fibrosis.
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Chinese scholars have made progress in the construction of light/cobalt synergistic catalytic axial chirality
Time of Update: 2022-10-14
This study not only provides a new idea for the asymmetric radical coupling reaction catalyzed by light/cobalt collaboration, but also provides a new method for the preparation of axial chiral heteroaryl skeleton and related functional materials.
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Nature reshapes mitochondria to affect the immune system
Time of Update: 2022-10-14
A new study of immune system Th17 cells suggests that the shape and function of their mitochondria (the dynamics of cells) are important in autoimmune and inflammatory diseases such as multiple sclerosis.
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Nature opens up a whole new field of research into "junk" DNA – the rupture of "junk" DNA leads to new insights into neurological diseases
Time of Update: 2022-10-14
A new study has identified how oxidative disruption is formed and repaired in what scientists consider "junk" DNAThe study also found that fixing these breaks plays a vital role in protecting us from
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Science Advances' new view: Obesity is a neurodevelopmental disorder
Time of Update: 2022-10-14
”Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index In recent decades, the number of obese people has increased rapidly, affecting more than 2 billion people, making it one of the biggest causes of poor health worldwide.
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Chinese scholars and overseas collaborators have made progress in molecular motor research
Time of Update: 2022-10-14
: 21971267), Professor Depeng Zhao and collaborator Ben Feringa of Sun Yat-sen University reported that the use of chemical energy to drive molecular motors to achieve high unidirectional continuous rotation.
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PNAS describes for the first time the underlying mechanism by which drugs increase brown fat in adults
Time of Update: 2022-10-14
This study describes for the first time a drug-based approach to increasing the quality of brown adipose tissue (BAT) adult animals.
This study describes for the first time a drug-based approach to increasing the quality of brown adipose tissue (BAT) adult animals.
