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AM(IF=32) Fang Yin, Tongji University/Zhang Fan of Fudan University, developed novel nanomaterials to achieve minimally invasive, high spatiotemporal resolution neuromodulation
Time of Update: 2022-11-04
On October 27, 2022, Fang Yin of Tongji University and Zhang Fan of Fudan University jointly published a paper entitled "Transcranial Non-genetic Neuromodulation Via Bioinspired Vesicle-Enabled Precise NIR-II" online in Advanced Materials Optical-stimulation", which reports that second near-infrared (NIR-II) light is obtained from a vesicle-membrane-restricted enzymatic reaction by biomimetic nanovesicles-induced transcranial non-genetic neurostimulation.
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NAN-Yuan Linhong's research group revealed that DHA intervention had different effects on brain lipid levels, fatty acid transporter expression and Aβ metabolism in ApoE-/- and C57 WT mice
Time of Update: 2022-11-04
Recently, Yuan Linhong's research group of Capital Medical University published a report entitled " Discrepant Modulating Effects of Dietary Docosahexaenoic Acid on Cerebral Lipids, Fatty Acid Transporter Expression and Soluble Beta-Amyloid Levels inApoE -/-and C57BL/6J mice" explores defects in the ApoE gene and the effects of DHA dietary interventions on the brain Effects of Aβ production and lipid levels.
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Neurology: The combined effect of synaptic and axon integrity on longitudinal gray matter atrophy in adults with unimpaired cognitive function
Time of Update: 2022-11-04
study published in Neurology tested whether cerebrospinal fluid (CSF) synaptic protein concentrations similarly mitigated the effects of axonal injury on brain atrophy in clinically normal adults, as indicated by cerebrospinal fluid neurofilament [NFL].
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Cell was once bitten by a snake, ten years afraid of the well rope! Cao Peng/Xie Zhiyong/Shang found the internal organs of the toxin-induced defense response to the brain axis from equal
Time of Update: 2022-11-04
On November 1, 2022, Cao Peng, Xie Zhiyong, Wang Fengchao and Shang Congping of Guangzhou National Laboratory of Beijing Institute of Biological Sciences published a research paper entitled "The gut-to-brain axis for toxin-induced defensive responses" online at Cell The study developed a mouse-based paradigm to study bacterial toxin-induced defense responses.
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The Chinese team's blockbuster research on stroke in both brains reached the top of NEJM at the same time, ushering in a breakthrough in thrombectomy treatment
Time of Update: 2022-11-01
▎WuXi AppTec content team editorAcute basilar artery occlusion (aBAO) is an acute cerebrovascular occlusive disease that accounts for about 1% of all stroke diseases. Although the incidence is low, th
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Nat Neurosci Review—Overview of presynaptic optogenetic tools
Time of Update: 2022-11-01
discussed gene therapy innovation for neurodegenerative diseases and ophthalmic diseasesWelcome to "Logical Neuroscience"[1]" "Logical Neuroscience" Recruitment for editor/operation positions ( Online office)[2] Talent recruitment - " Logical Neuroscience " Recruitment article interpretation / writing position ( Network part-time, online office) End of this articleSource—Privy SealWritten by - Pivotal SecretResponsible editor—Wang Sizhen, Fang Yiyi Editor—Summer LeafOptogenetics expresses light-sensitive proteins in specific cell populations and manipulates cellular activity at the subcellular, cellular, circuit, and behavioral levels through light.
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Cell: Not only is pain an unpleasant experience, it also plays a key role in maintaining gut health
Time of Update: 2022-11-01
Together, these findings suggest that nociceptor neurons and their signaling to goblet cells via the CGRP-Ramp1 axis play a key role in intestinal barrier protection.
Together, these findings suggest that nociceptor neurons and their signaling to goblet cells via the CGRP-Ramp1 axis play a key role in intestinal barrier protection.
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Slow movement + stiff limbs, don't just think about Parkinson's disease!
Time of Update: 2022-11-01
The patient took "olanzapine, donepezil, memantine" for two months due to memory loss without obvious cause 2 years before admission, accompanied by episodic visual hallucinations, dizziness and sleep disorders, and the treatment effect was not good.
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The world's first enthesitis guidelines released! Find out the "invisible killer" behind the SpA
Time of Update: 2022-11-01
In order to fill this gap, Professor Gu Jieruo of the Department of Rheumatology and Immunology of the Third Affiliated Hospital of Sun Yat-sen University took the lead in compiling the Clinical Practice Guidelines for the Screening and Evaluation of Enthesitis in Patients with Spondyloarthritis [1], which was recently published in the journal Frontiers in Immunology.
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Science: Unravel the early mysteries of Huntington's disease, cure or discover important opportunities!
Time of Update: 2022-11-01
Early enhancement of glutamatergic synaptic transmission can rescue dendritic branching and sensorimotor deficits in HD model miceSo does early CX516 treatment affect HD-related phenotypes in adult mice?The researchers injected the newborn mice subcutaneously twice a day for the first week, and then tested the relevant phenotypes at different times in adulthood, and different behavioral experiments showed that early CX516 treatment could delay the appearance of HD-related behavioral defects in adulthood.
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Reduction of monoamine neurotransmitters - thinking about the treatment of depressive disorder after stroke
Time of Update: 2022-11-01
GuidePost-stroke depression (PSD) refers to a syndrome that occurs after stroke, manifested as a series of depressive symptoms and corresponding physical symptoms, and the latest expert consensus on p
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Lei's team at the Institute of Medicine of Northwestern Polytechnical University applied electrical impedance tomography to locate epileptogenic foci and detect and predict seizures
Time of Update: 2022-11-01
Wang Lei's team at the Institute of Medical Science of Northwestern Polytechnical University has been committed to the research of electrical impedance tomography applied to epileptic foci localization, seizure detection and prediction.
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NSR(IF=23) Good news! Li Haohong and other teams at Zhejiang University found that time-restricted eating can improve excessive nighttime sleepiness
Time of Update: 2022-11-01
Overall, the study suggests that random intake of HFD leads to PVT inactivation, which is essential for impaired nocturnal awakenings and increased sleep, while TRF can prevent and reverse diet-induced PVT dysfunction and excessive sleepiness.
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There are cysts in the brain, what causes it?
Time of Update: 2022-11-01
Diagnostic criteria for neurocysticercosis in ChinaThere are corresponding clinical signs and symptoms, such as seizures, increased intracranial pressure, mental disorders and other brain symptoms and signs, basically excluding other diseases that need to be differentiated.
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【Cell】Don't take painkillers! Harvard Medical School discovered the amazing protective properties of pain
Time of Update: 2022-11-01
This article is the original of Translational Medicine Network, please indicate the source of reprinting By JevinResearchers at Harvard Medical School analyzed molecular crosstalk between pain fibers
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Parkinson's disease with the same target two monoclonal antibodies failed, where will the next opportunity in the field of PD be?
Time of Update: 2022-11-01
The two drugs and their counterparts are Prasinezumab and PASADENA and Cinpanemab and SPARK, two highly anticipated α-syn monoclonal antibodies bibifold: After 52 weeks of use, patients in the two experimental groups of patients with movement disorders learned the Unified Parkinson's Disease Rating Scale(MDS-UPDRS).
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Cognitive and gait impairment in a 23-year-old woman with clinical reasoning
Time of Update: 2022-11-01
What is the next step in the assessment?Part IIThe differential diagnosis of cognitive impairment and gait disturbance with white matter changes is wide-ranging, including inflammation/autoimmunity (the patient's rate of progression is not supported), infectious (no other symptoms of infection and chronic course is not supported), tumor (the patient's rate of progression is not supported), neurogenetics (genetic degeneration, metabolic diseases, etc.
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Neuron: Xiaowei's team revealed the neural circuits that enhance social memory during dreaming
Time of Update: 2022-11-01
004The images in the article are from referencesFigure 2: Inhibition of the SuM-CA2 neural circuit impairs social memory3The SuM-DG neural circuit regulates spatial memoryIn spatial learning and memory experiments, photoinhibition of SuM-CA2 neural circuits during REM does not affect the spatial memory ability of mice.
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How is symptomatic intracranial atherosclerotic stenosis treated endovascularly? The latest consensus is coming!
Time of Update: 2022-11-01
*For medical professionals onlyAfter 4 years, 20 opinions have been updatedIntracranial atherosclerotic stenosis (ICAS), also known as intracranial atherosclerotic disease (ICAD), is a common cause of
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Weakness in the limbs, impaired consciousness, this cause is surprising!
Time of Update: 2022-11-01
■ Positioning diagnosis:Figure 2■ Qualitative diagnosis:The patient is an elderly man with a history of cerebral infarction and a long-term history of alcoholism, this time with poor muscle strength in both lower limbs, difficulty swallowing, choking on water, incontinence, and no abnormal hyperintensity in the head DWI.
