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Neuron makes progress again! Chen Xiaowei and other teams at the Army Medical University have discovered potential neural circuits for social memory consolidation
Time of Update: 2022-11-01
iNatureThe hippocampal CA2 region plays a key role in social memory. The encoding of this memory involves afferent activity from the suprathalamic nucleus (SuM) to CA2. However, the neural circuits ne
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Tracing the origin——Starting from the physiological mechanism of ASCVD disease, look at the lipid-lowering treatment strategies of ischemic stroke patients
Time of Update: 2022-11-01
Ischemic stroke is a type of atherosclerotic cardiovascular disease (ASCVD). Elevated low-density lipoprotein cholesterol (LDL-C) is one of the most important risk factors for the development of ASCVD
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Can't stop drinking for a long time? Probably "controlled" by this neuron!
Time of Update: 2022-11-01
Click "Read Original" to get more clinical dry goodsProfessor Bartlett said: "We know that alcohol has a great deal of damage to both neurons-brain cellsthe research team will continue to work on new alcohol abuse and addiction treatment strategies, with a focus on understanding how to improve neuroplasticity to restart brain health and physical and mental health.
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Vertigo time · Stage 1 History of patients with vertigo/vestibular disease
Time of Update: 2022-11-01
Chief complaint/present medical history: onset form + core symptoms (the main symptoms of this visit; It also includes information collection, differential symptoms, and dynamic outcomes of diagnosis and treatment of core symptoms of vestibular impairment (vertigo/dizziness/vestibulo-visual symptoms/postural symptoms) and their associated duration, precipitating factors (spontaneous or prevoked onset), and accompanying symptoms (especially neurological symptoms, hearing, psychiatric and medical symptoms); B.
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Author's interpretation| Zeng Kewu/Tu Pengfei of Peking University revealed a new target of neuroinflammation regulated by the active ingredient of Chinese medicine Mustang
Time of Update: 2022-11-01
On August 12, 2022, Zeng Kewu/Tu Pengfei from the State Key Laboratory of Natural Medicine and Biomimetic Drugs of Peking University published a paper entitled " Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy deeply reveals the active ingredient of Chinese medicine Mustang chasing lactone B ( Eupalinolide B (EB) allosteric regulation target USP7, thereby exerting a molecular mechanism of anti-neuroinflammation and improvement of neurodegenerative diseases through the Keap1/Nrf2 signaling pathway.
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Neural Regen Res Review—The Role and Potential of Microglia Polarization and Dialogue with Other Cells in the Treatment of Alzheimer's Disease
Time of Update: 2022-11-01
) - Using bibliometrics to analyze the research trends of astrocytes and stroke; Neural Regen Res Review—Advantages of Rho kinase and its inhibitor Fasduil in the treatment of neurodegenerative diseases; A Review of Front Aging Neurosci – The double-edged role of astrocytes in neurovascular units after cerebral ischemia) Microglia are disease regulators in ADAD is a degenerative disease of CNS, with cognitive function and behavioral disorders as the main clinical features, and has received increasing attention in modern society [1].
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How can subarachnoid hemorrhage prevent cerebral vasospasm? Intrathecal nicardipine is beneficial
Time of Update: 2022-11-01
Inthecal nicardipine is effective and safe for cerebral vasospasmIn the nine studies included in this systematic retrospective analysis, intrathecal nicardipine was initiated when TCD-measured middle cerebral artery (MCA) blood flow velocities of more than 120 cm/s, regardless of whether the patient had clinical deterioration.
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Research Yan Chaogan's research group developed a practical Alzheimer's disease brain imaging deep learning discriminator
Time of Update: 2022-11-01
Recently, Yan Chaogan's research group of the Key Laboratory of Behavioral Sciences, Chinese Academy of Sciences, published a paper entitled "Building a practical Alzheimer's disease brain imaging deep learning discriminator based on 85,721 samples" in the Journal of Big Data (IF=10.
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【Review】The role and therapeutic value of astrocytes in neurological diseases
Time of Update: 2022-11-01
Figure 1: Astrocyte subsets and plasticity2Function of astrocytesAstrocytes are involved in key processes related to CNS homeostasis, including neurotransmitter circulation, ion balance, energy metabolism, regulation of synaptogenesis and synaptic transmission, and maintenance of the blood-brain barrier.
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Nature Medicine: Alzheimer's Early Screening Evidence Updated! The scientists found that two blood markers are closely related to early Aβ pathology
Time of Update: 2022-11-01
This means that in the preclinical stage of Alzheimer's disease, p-tau231 and p-tau217 have great potential to become plasma markers for screening for Aβ pathology.
This means that in the preclinical stage of Alzheimer's disease, p-tau231 and p-tau217 have great potential to become plasma markers for screening for Aβ pathology.
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In Alzheimer's disease clinical trials, can changes in Aβ levels represent cognitive changes?
Time of Update: 2022-11-01
gov identified RCT-related drugs that were 'completed', 'terminated', or 'effective, not recruited'; In addition, the trial required a placebo-controlled group and standardized uptake ratio (SUVR) for amyloid β measured by positron emission tomography (PET) and cognitive function measured by the Dementia Severity Rating Scale (CDR-SB), Alzheimer's Disease Rating Scale-Cognitive Scale (ADAS-Cog), and the Simple Mental State Scale (MMSE) to verify the relationship between changes in Aβ-PET SUVR and changes in cognitive function.
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Cognitive and gait impairment in a 23-year-old woman with clinical reasoning
Time of Update: 2022-11-01
What is the next step in the assessment?Part IIThe differential diagnosis of cognitive impairment and gait disturbance with white matter changes is wide-ranging, including inflammation/autoimmunity (the patient's rate of progression is not supported), infectious (no other symptoms of infection and chronic course is not supported), tumor (the patient's rate of progression is not supported), neurogenetics (genetic degeneration, metabolic diseases, etc.
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Gong Qiyong team iScience: Gray matter network dysfunction in patients with social anxiety disorder|Cell Press paper express
Time of Update: 2022-11-01
InterdisciplinaryInterdisciplinaryOn September 8, 2022, Gong Qiyong's team from the Magnetic Resonance Research Center (HMRRC) of West China Clinical Medical College of Sichuan University published a
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Nature: A multi-omics map of organoid development in the human brain
Time of Update: 2022-11-01
The study established a multi-omics map of human brain organoid development, demonstrating for the first time that the transcription factor GLI3 is involved in the formation of human forebrain patterns.
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Master the key points of "autoimmune encephalitis" treatment, it is enough to master this article
Time of Update: 2022-11-01
Studies have shown that about 97% (42/43) of patients with this disease received immunotherapy at the first onset of the disease, and first-line immunotherapy drugs include steroids, IVIg; Rarely, second-line immunotherapies such as rituximab, cyclophosphamide, mycophenolate mofetil, azathioprine, and tacrolimus are used.
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Cerebrovascular disease can also be secondary to seizures, this article is a complete summary
Time of Update: 2022-11-01
Cerebrovascular disease can cause seizures, and often become the first symptom of its onset, at the same time seizures can also cause cerebrovascular diseases, thereby bringing difficulties to diagnos
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How is status epilepticus diagnosed and treated in children? Take a look at the latest Chinese expert consensus
Time of Update: 2022-11-01
Status epilepticus (SE) is one of the critical diseases of the children's nervous system characterized by persistent seizures and may cause damage to the nervous system and even multiple organs, with
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Nature: Human-derived brain-like organs connect animal neural circuits to drive reward behavior
Time of Update: 2022-11-01
1038/s41586-022-05277-wThe images in the article are from referencesFigure 3: The neural circuit formed by hCO is functionalsummaryIn this paper, human-derived brain-like organs cultured in vitro were transplanted into rats, which can be successfully integrated into existing neural circuits and can play the function of regulating behavior.
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Science Café Expert Review: Sleep to anxiety, listen to pain
Time of Update: 2022-11-01
。 SDS induces socially frustrated mice to sleep in the next few hours, and researchers such as researcher Yu Xiao from Imperial College London and Professor Dong Hailong's team at Xijing Hospital of the Fourth Military Medical University of China found that this restorative sleep activates a small number of nerve cells located in the ventral tegmental area (VTA) of the midbrain [1].
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Another way: efficiently delivers AAV to the brain through the nose, bypassing the blood-brain barrier
Time of Update: 2022-11-01
The study, which validates the team's previously developed focused ultrasound intranasal delivery (FUSIN) method in a mouse model for the first time, confirms that FUSIN is able to break through the blood-brain barrier (BBB) and convert adeno-associated viral vectors (AAV) is efficiently delivered to the brain through the nose.
