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The express AI platform discovered a new target, and the innovative treatment of "ALS" entered the clinic
Time of Update: 2022-11-15
▲If you have any business needs, please long press to scan the QR code above, or▎ WuXi AppTec content team editor Today, Verge Genomics announced that its investigational therapy VRG50635 completed the first subject in a Phase 1 clinical trial.
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Alzheimer's disease research has reached a critical juncture of "paradigm shift"
Time of Update: 2022-11-15
11. 7 The Intellectual"Intellectual frontier scholar", senior researcher of Shenzhen Bay Laboratory Wang LimingIntroductionIn July, an investigative report in the journal Science revealed that an impo
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4 common pontine syndromes, one article to master
Time of Update: 2022-11-15
Come to the "Doctor Station" and take a look 👇:Fig. 2 Positioning diagnosissummary, contralateral hemiplegia(pyramidal tract involvement); Inability to abduct the eyeball on the side of the lesion(abductor nerve involvement); Paralysis of staring at the lesion side of both eyes is Fowier syndrome in pontine infarction.
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J Neuroinflammation—Zhuo Yehong/Su Wenru's team revealed that iron death may be a new mechanism and therapeutic target of retinal ischemia-reperfusion
Time of Update: 2022-11-15
the first time, the researchers constructed a single-cell atlas of retinal ischemia-reperfusion injury in mice, suggesting that targeted inhibition of iron death can effectively protect retinal structure and function.
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Cell: Cao's team revealed the neurobiological mechanisms by which the brain initiates the "nausea-vomiting" response
Time of Update: 2022-11-15
Applying the newly established food poisoning research paradigm, Cao Peng's team found that enterochrome cells play an important role in the "nausea-vomiting" response, and may be "informants" that help the brain sense pathogenic invasion.
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A new therapeutic strategy for on-demand and cell-autonomous genes that can stop seizures in mice | selected by Science One Week
Time of Update: 2022-11-15
Welcome to pay attention to the official scientific public accountClick "Read Original" below to access the original English articleLight up your likes for this issue of ScienceClick on the blue words above to follow usThe researchers report that a gene that can be expressed as needed to inhibit neuronal activity offers a new way to reduce spontaneous seizures in mice.
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Face the pain points of stroke treatment! Pay attention to brain cell protection and help stroke patients manage the whole course of the disease
Time of Update: 2022-11-15
*For medical professionals onlyThe whole course of stroke is managed and brain cell protection is crucial. Stroke is the largest cause of death in adults in China, and the incidence rate ranks first
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The brain-gut axis adds to the evidence that the gut microbiota can talk directly to the brain to regulate diet and body temperature
Time of Update: 2022-11-15
Cerebral gut axis regulates metabolism: Eating leads to the expansion of the gut microbiota, which increases the release of muropeptides, a gut bacterium that, when in the brain, target inhibitory hypothalamic NOD2 receptors and reduce neuronal activity, helping to regulate satiety and body temperature.
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Can classic markers of Alzheimer's disease help with early screening?
Time of Update: 2022-11-15
However, after correcting for age, sex and APOE alleles and corrected by Bonferroni, plasma t-tau and NfL in the AD group increased significantly compared with the CN group (p 。Fig. 1 Comparison of plasma biomarkers between AD group and CN groupCorrelation between plasma biomarkers and demographic characteristicsNext, the authors analyzed correlations between plasma biomarkers and demographic data, including age of onset (AAO), age at diagnosis, disease course, and level of education.
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Brain partitioning is not the key to function! Science cover 4 articles in a row: wisdom is born from the inter-regional connection of the brain
Time of Update: 2022-11-15
Alex James from the Recessed Temple Qubit | Official number QbitAIIt's time to rediscover how our brains work!The latest issue of Science, a special issue, publishes 4 papers in a row, pointing to the
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Ageing Res Rev Review—New Insights Between Ecological Disorders of the Gut Microbiome and Parkinson's Disease: Pathogenicity and Clinical Relevance
Time of Update: 2022-11-15
Written by Bi Mingxia, edited by Wang Sizhen, edited by Fang Yiyi - Xia YeParkinson's disease (PD) is a complex neurodegenerative disease characterized by denergic dopamine neuronal degeneration in th
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Cell Res Yin Wanchao/Xu Huaqiang of the Chinese Academy of Sciences collaborated to reveal the molecular recognition mechanism of Bombesin receptor for itching-related neuropeptides
Time of Update: 2022-11-15
iNaturePruritus, especially persistent (or chronic pruritus) in patients with allergic skin disease and/or neurological disorders, significantly affects sleep, mood, and personal health. Extensive eff
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Neuron Huang's team found that a new blood-tumor barrier composed of mechanically sensitive tumor cells hindered brain tumor chemotherapy
Time of Update: 2022-11-15
++Knocking out Piezo2 reversed the WNT/β-Catenin signaling state between Sox2+ tumor cells and vascular endothelial cells, and activated resting Sox2+ tumor cells while destroying the blood-tumor barrier, greatly enhancing the response of medulloblastoma to chemotherapy.
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Front Neurol: Stroke prevalence and risk factors in 1.4 million adults in China
Time of Update: 2022-11-14
Participants with MRI-defined BI were more likely to be older men with a higher prevalence of overweight or obesity, hypertension, diabetes, and dyslipidemia than participants without MRI-defined BI (all PTable 1 Characteristics of cerebral infarction status of study participants as defined by MRIMRI-defined prevalence of cerebral infarctionOf the 1,431,527 study participants, 100,245 (7.
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Laryngoscope: Long-term cognitive assessment of older workers with cochlear implants
Time of Update: 2022-11-14
The rate of cognitive decline appears to be similar in older CI patients, regardless of preoperative cognitive statusOriginal source:Original source:Jacques A Herzog， Craig A Buchman， Dorina Kallogjeri et al.
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Interpretation of the national guidelines for neurofibromatosis type I in France in 2020
Time of Update: 2022-11-14
Interpretation of the national guidelines for neurofibromatosis type I in France in 2020Interpretation of Neurofibromatosis 1 French national guidelines based on an extensive literature review since 1
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Alzheimer & Demantia: Early Alzheimer's disease has a high incidence, but recognition rates are far underestimated!
Time of Update: 2022-11-14
References:Estimating prevalence of early Alzheimer's disease in the United States, accounting for racial and ethnic diversity Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia, a dementia syndrome.
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BMC MED: Subversion – What is the investigation of the causal relationship between ALS and autoimmune diseases?!
Time of Update: 2022-11-14
Reverse MR analysis also does not support the effect of ALS responsibility on other autoimmune diseases.
Reverse MR analysis also does not support the effect of ALS responsibility on other autoimmune diseases.
Reverse MR analysis also does not support the effect of ALS responsibility on other autoimmune diseases.
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China's "Clinician AD Diagnosis and Treatment Attitude Report" was released to help break the obstacles to early diagnosis of Alzheimer's disease
Time of Update: 2022-11-14
On November 5, sponsored by the Psychiatry and Mental Health Branch of the Chinese Geriatrics Association, co-organized by the Brain Hospital Affiliated to Guangzhou Medical University and the Third
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An unforgettable map of ventricular anatomy
Time of Update: 2022-11-14
In which sagittal position the three ventricles areCoronal positionThe three ventricles are connected to both ventricles by bilateral interventricular foramen and to the four ventricles through the midbrain aqueduct.
