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Cell Sub-journal: Bin1 protein, the second leading risk factor for late-onsis AD, is also the key to the integration of spatial memory in the brain!
Time of Update: 2020-07-22
To sum up, this study emphasizes that: 1) the loss of Bin1 in neurons may damage the spatial memory integration function of the brain; 2) neuronal Bin1 regulates the release of presynaptic neurotransmitters The excitatory synaptic transmission in cKO mice is defective; 3) BIN1 can regulate the release of presynaptic vesicles in hippocampal excitatory synapses; 4) emphasizes the non redundant role of BIN1 in presynaptic regulation.
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Nat Comm . . . For the first time, zheng Dayi's team constructed a mouse model of simple autonomic neurodysfunction induced by alpha-synaptic nucleoprotein fibrosis.
Time of Update: 2020-07-22
on February 18, 2020, the research group of Teng Junfang / Wang Xuejing / Ding Xuebing, the First Affiliated Hospital of Zhengzhou University, published the title of autonomous injection of α - synuclein fabrics as a model of pure automatic failure α - synuclein pathway This study fills in the blank of a-syn-induced phenotype animal model of autonomic nerve dysfunction, which is helpful to further explore the pathological mechanism of α - synuclein disease-related autonomic nerve dysfunction.
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Cell Metabolism . . . The joint research results of the Xu Xiaoming/Sheng Zuhang team have improved energy supply to help restore spinal cord injury.
Time of Update: 2020-07-22
by removing the mitochondrial anchor protein synthaphilin (snph) from nerve cells, the transport efficiency of mitochondria in axons was increased, or creatine in neurons was supplied by exogenous The contents of creatine and creatine phosphate can increase the energy supply of damaged neurons, thus promoting axonal regeneration, nerve circuit reconstruction and motor function recovery after spinal cord injury.
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Science . . . 50,000 MRI images! The genetic structure of the human cerebral cortex is fully analyzed.
Time of Update: 2020-07-22
the genetic diversity of human cerebral cortex surface area and thickness is closely related to various phenotypes in neurology, psychology and behavior, and the above two data can be measured in vivo by MRI (Fig. 1).
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Why does flashing light fight Alzheimer's? It is triggered by the release of signal ingress in the brain.
Time of Update: 2020-07-22
As early as 2016, studies have found that in mice with Alzheimer's disease, 40 Hz flicker light can activate microglia to clear garbage, thus providing a new way to manipulate the nervous immune system.
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Nature sub-journal: Humans have discovered the first genetic mutation that improves cognitive flexibility.
Time of Update: 2020-07-22
this study describes a Pin1 dependent mechanism that regulates the association of Kv4.2, a subtype of potassium channel a, with its accessory subunit ddpp6, thereby altering neuronal excitability and cognitive flexibility.
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Nature has made significant progress. Old and not old! Cai Shiqing/Jiang Lubin discovered its potential molecular mechanism.
Time of Update: 2020-07-22
through genome-wide RNA interference based gene screening, the researchers identified 59 genes as potential regulators of age-related behavior deterioration rate.
therefore, the whole genome RNA interference screening in Caenorhabditis elegans revealed the conservative epigenetic negative regulatory proteins of aging, and suggested a possible way to achieve healthy aging.
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Neuron. Zhou Jiangning found neurons in the brain responsible for stress response behavior.
Time of Update: 2020-07-22
then, in vivo microscopic imaging method was used to observe that the activity of CRF neurons increased when mice took active coping behavior in the face of negative pressure.
promoting the activity of CRF neurons in medial prefrontal cortex can enhance the active coping behavior and enhance the resistance to environmental negative pressure.
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Science paper: The human brain can perform XOR iso-dosing with just a single neuron.
Time of Update: 2020-07-22
Each of the micro cells in the dendrite arm of cortical neurons can perform complex operations in mathematical logic, instead of needing multilayer neural networks as previously thought.
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Progress has been made in the study of the development of the cortex.
Time of Update: 2020-07-22
on February 20, cerebral cortex, an International Journal of cortical research, published online the research paper of Wang Xiaoqun, Institute of Biophysics, Chinese Academy of Sciences.
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Cell Metabolism . . . The calCR neurons in the hind brain are involved in regulating non-anorexic indentation.
Time of Update: 2020-07-22
Myers, University of Michigan, USA, The Jr. team and Clemence blouet team of Cambridge University (the first author is Dr. Wenwen Cheng) jointly published an article in the journal cell metabolism: calcium receptor neurons in the mouse nucleus tractus solitarius control energy balance via the non adverse suppression of Feeding revealed that the activation of CALCR neurons in the hindbrain can inhibit food intake without causing anorexia.
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Funny soul! Artificial intelligence cracks "whispering" in mice in social behavior
Time of Update: 2020-07-22
neuunebel research team from the Institute of psychology and brain science, University of Delaware, published an article in nature neuroscience in March 2020, revealing the above-mentioned connection by using the method of deep learning: the voice patterns of mice under different social behaviors, revealing the "whispering" of mice in different social behaviors, and translating the mouse language.
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Nature Sub-journal: Professor Feng Guoping reveals the key mechanisms for autism perception abnormalities.
Time of Update: 2020-07-22
in order to further explore the neuronal mechanism of this tactile abnormality, researchers injected gcamp6, a calcium indicator of excitatory neuron promoter, into the primary somatosensory cortex to observe the spontaneous calcium activity in wild-type mice and shank3b knockout mice.
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Nature. A new target for neurodegenerative diseases has been found: inhibiting the spread of tau.
Time of Update: 2020-07-22
in conclusion, the results of this study confirm that LRP1 is a key regulator of tau diffusion in the brain and therefore a potential target for the treatment of diseases involving the diffusion and aggregation of tau.
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Shandong University Wang guanfeng group was invited to review the NLR protein regulatory factors, worthy of collection!
Time of Update: 2020-07-22
recently, the research group of Wang Guanfeng, School of life sciences, Shandong University, was invited to publish the title "fine tuning immunity: players and regulators for plant NLRs" in trends in plant science ”In this review, the functional classification of NLR interacting proteins was systematically carried out, and the mechanism of interaction proteins was carefully sorted out and summarized.
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Science . . . GuYan/Wang Lang team reveals that immune cells in the brain are the 'masterminds' of memory forgetting
Time of Update: 2020-07-22
Memory is one of the most important functions of the brain and one of the most studied brain functions. memory occurs at any time, while forgetting is accompanied by a shadow. the hippocampus, located
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Say it you might not believe it... There is the smell, smell edified.
Time of Update: 2020-07-22
} the corresponding author of the study, Professor Wang Meng (photo source: Baylor Medical College official website) in this study, scientists found that after gene mutation of a group of AWC olfactory neurons, nematodes did not eat more or move less, but with the decline of lipid metabolism, the fat stored in the intestine increased - the fat of nematodes was mainly stored in the intestine.
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Nat Neurosci . . . Feng's team found the central nervous mechanism of sensory abnormalities in autism.
Time of Update: 2020-07-22
Moore of Brown University jointly published on the journal Nature Neuroscience the dysfunction of cortical GABAergic nerves leads to sensory hyper reactivity in a Shank3 model of In the long article of ASD, it was found that Shank3 gene knockout mice in ASD animal model had similar hypersensitivity phenotype with clinic.
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Nature. Why does stress cause white hair?
Time of Update: 2020-07-22
on January 22, 2020, Harvard University's Hsu Yajie Laboratory (Dr. Zhang Bing as the first author) published the title of hyperactivation of sympathetic nerves drives decomposition of melanocyte stem in the journal Nature The study of cells revealed for the first time the exact mechanism of this phenomenon: stress activates the sympathetic nervous system as part of the fight or flight response, and causes permanent damage to the melanocyte stem cells in hair follicles.
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China University of Science and Technology has discovered neurons in the brain responsible for stress response behavior.
Time of Update: 2020-07-22
using gene manipulation mice, combined with behavioral science, pharmacogenetics and in vivo microscopic imaging technology, Zhou Jiangning research group of University of science and technology of China has found that under various behavioral challenge scenarios, the adrenocorticotropic hormone releasing hormone (CRF) neurons in the medial prefrontal lobe are the neurobiological basis for choosing "fight or escape".
