Say it you might not believe it... There is the smell, smell edified.

Everyone knows that eating more and moving less is easy to gain weight.but a recent scientific study has found that, without increasing food intake or reducing exercise, experimental animals have more fat just by smelling a certain smell.smell can make you fat?! The work, published in nature communications, is led by Professor Wang Meng of Baylor College of medicine.the researchers chose nematodes as the experimental objects to study fat metabolism.on the one hand, the whole body of nematodes is transparent, and researchers can directly see how the lipid molecules in the nematodes distribute and change by using an innovative chemical imaging technology - simulated Raman scattering microscope.on the other hand, as a model animal, the complete neural network of nematodes has been clarified, and scientists can quickly find out which neurons may be involved in the regulation through common genetic means.} the corresponding author of the study, Professor Wang Meng (photo source: Baylor Medical College official website) in this study, scientists found that after gene mutation of a group of AWC olfactory neurons, nematodes did not eat more or move less, but with the decline of lipid metabolism, the fat stored in the intestine increased - the fat of nematodes was mainly stored in the intestine.considering that the activity of different olfactory neurons is regulated by specific odor molecules, this phenomenon leads scientists to speculate that odor molecules that stimulate olfactory neurons of AWC may directly regulate lipid metabolism and fat reserve.to test this hypothesis, the researchers conducted a set of odor exposure experiments: instead of giving nematodes food, they just gave them different tastes.after small-scale screening of some common odor molecules, the researchers noticed that when 2-butanone was present in the container, the activity of olfactory neurons in AWC was inhibited, and the body fat content increased rapidly after the nematode smelled for 4 hours.fortunately, the regulation effect is dynamic and reversible. When the sweet smell is eliminated, the fat level will be restored.through RNA interference and other experimental means, the researchers clarified from the molecular mechanism how the downstream neuroendocrine activities regulate lipid metabolism after odor activated this group of olfactory neurons.the elucidation of these signaling pathways also provides many clues for the intervention of fat regulation.} research sketch (photo source: reference [1]) combined, this study reveals the effect of olfactory perception on fat metabolism, and suggests that not all odors, but some particular odors may play a key role.of course, olfactory is very complex, and different combinations of odor receptors in olfactory neurons make olfactory perception have great individual differences.in our daily life, we must know that some people have the same smell (for example, durian smell), and some people feel like vomiting when they smell the same smell.therefore, the authors of the study concluded that the findings suggest that different olfactory perceptions may be associated with different degrees of obesity. if we further study these associations, we will have new methods to prevent and treat obesity. source: pixabay reference [1] ayse Sen Mutlu et al., (2020) olfactory specification regulations lipid metadata through neuroendocrine signaling in Caenorhabditis elegans. Nature communications. Doi: