Shandong University Wang guanfeng group was invited to review the NLR protein regulatory factors, worthy of collection!

Plants have evolved complex immune systems in the process of resisting pathogens.NLR (nucleoside binding, leucine rich repeat) resistance protein is one of the most important components in plant immune system, and its activity is precisely regulated by intramolecular and intermolecular protein interactions, among which NLR interaction proteins play an important role.recently, the research group of Wang Guanfeng, School of life sciences, Shandong University, was invited to publish the title "fine tuning immunity: players and regulators for plant NLRs" in trends in plant science ”In this review, the functional classification of NLR interacting proteins was systematically carried out, and the mechanism of interaction proteins was carefully sorted out and summarized. The application prospect of NLR in crop improvement was discussed, and the possible research direction in the future was proposed.in this paper, NLR interacting proteins are classified into seven categories, including transcription regulators, kinases or pseudokinases, chaperones or cochaperones, ubiquitin ligase, small GTPase related proteins, paired NLRs and other types of interaction proteins (Fig. 1).according to the existing studies, the types of NLR interacting proteins, the interaction domains with NLR proteins, the experimental methods for verifying the interactions, the functions of the interacting proteins, the involved hosts, pathogens and effector proteins were systematically summarized.taking the NLR protein snc1 as an example, this paper explains how different types of interaction proteins regulate the activation and degradation of snc1 protein (Fig. 2).this is of great significance for understanding the mechanism of NLR and its interacting proteins in different plants.Fig. 1: six main types of NLR interacting proteins. Fig. 2: different types of interaction proteins participate in the regulation of snc1 activity. The research group of Wang Guanfeng has long been engaged in the excavation and regulation mechanism of plant NLR interaction proteins.the first unit of this article is Shandong University. Sun Yang, assistant researcher of Wang Guanfeng's research group, is the first author, and Professor Wang Guanfeng is the corresponding author.ZHU Yuxiu, a postgraduate student of our research group, is a co-author of Professor Peter Balint Kurti of North Carolina State University.the research was supported by National Natural Science Foundation of China, national key R & D program and Shandong natural science foundation.Article links: