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Nature back-to-back . . . Milestone! In vitro reveals the characteristics of the "section clock" during the occurrence of human body sections.
Time of Update: 2020-07-22
first of all, the researchers used activin A and FGF to induce ectoderm formation of mouse embryonic stem cells, and then cultured in medium containing Wnt agonist chiron99021 (chir) and BMP inhibitor ldn193189 (LDN) (CL medium), so as to reproduce the early stage of mouse paraxial mesoderm development in vitro (Fig. 2, left).
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Cell Heavyweights . . . Pioneering new directions, the first discovery was made by only about 100 neurons, dominating coughing, swallowing and other defensive reactions.
Time of Update: 2020-07-22
cell type specific photogenetic studies have shown that the rare vagus p2ry1 neurons (about 100 in each mouse) cause a series of airway protective responses, including expiratory reflex, vocal cord adduction, apnea and imaginary swallowing.
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PNAS: Compounds in apple skin can reverse neuronal damage in multiple sclerosis.
Time of Update: 2020-07-22
a new study in PNAS shows that ursolic acid, a compound found in the pericarps of apples, plums and other fruits and in some herbal medicines, can reduce further damage to neurons and help rebuild the protective sheath covering neurons, thus reversing this damage.
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Science Advances . . . Peking University Wanyou/Yi Ming precision "delete" animal-specific memories.
Time of Update: 2020-07-22
in conclusion, the crispr-sacas9 system, combined with electrophysiology, behavioral analysis, FACS and deep sequencing methods, provides a powerful strategy for precise genomic interference of brain function under physiological and pathological conditions.
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You think the only thing that's scary is a virus? 30% of humans have been infected with toxoplasmosis by cats, which allow the host to be more adventurous through "spiritual control".
Time of Update: 2020-07-22
Abstract: a recent study in the journal Cell reports found that Toxoplasma gondii infection made mice more eager to explore and eliminate their fear of cats, so that they were eaten by cats and promoted the transmission and reproduction of Toxoplasma gondii.
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Neuron. The Luo Minmin team revealed the neural loop mechanism by which mid-seam nucleus dopamine neurons regulate the reward-related memory expression.
Time of Update: 2020-07-22
on March 6, 2020, Luo Minmin Laboratory of Beijing Institute of life sciences published a research paper entitled "the raphe dopamine system controls the expression of intentional memory" in the journal Neuron.
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Nature Weight found that the sugar preference, actually from the intestines of the brain drive, finally know why can't quit milk tea and cola.
Time of Update: 2020-07-22
this study found that the glucose sensing pathway from the gut to the brain is crucial for the formation of sugar preference after food intake, and reveals the neural basis of different effects of sweeteners and sugars on behavior and the basic circuit of the effect of sugar on appetite.
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Science: Epigenetics of "Love Factor" dopamine regulates addictive behavior.
Time of Update: 2020-07-22
the projection of VTA brain area comes from the ventricular segmental area: cellular heterogeneity, connectivity and behaviour； doi:10.1038/nrn.2016.165 In March last year, Dr. maze Ian of Ikan Medical College in Mount Sinai published an article in the journal Nature for the first time, which revealed that the pentahydroxytryptamination of histone glutamine residues occurred at h3q5 site and belonged to monoamination modification.
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Nature Discovery: Adult brain damage, will "go back to the furnace"
Time of Update: 2020-07-22
in a new study published in nature on April 16, Beijing time, the research team led by the University of California, San Diego found that when adult brain cells are damaged, they will return to the embryonic state: in the immature state, these cells can regenerate new connections to help restore the lost function under appropriate conditions.
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Luo Minmin's team revealed a new mechanism of neural loop sydon sydon syllamen for memory expression regulation.
Time of Update: 2020-07-22
on March 6, 2020, Luo Minmin Laboratory of Beijing Institute of life sciences published a research paper entitled "the raphe dopamine system controls the expression of incentive memory" online in neuron, a journal of cell press.
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Science: Why "review is not easy to forget"? Zhejiang University team found for the first time: immune cells are "forgotten" "mastermind"!
Time of Update: 2020-07-22
after more than three years' efforts, Gu Yan research group and Wang Lang associate research group of Zhejiang University Medical College found that microglia used for immunity cause memory forgetting by clearing synapses, and further found that complement signaling pathway participated in microglia mediated forgetting and depended on the activity of memory imprinted cells.
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Current Biology . . . Cao Yujie and others reveal the mechanism of microtube microtube microtube skeleton regulation mediated by the negative end of the microtube.
Time of Update: 2020-07-22
hoogenraad team of Utrecht University in the Netherlands (the first author is Cao Yujie) published articles on Current Biology Magazine: microtubule min end binding protein camsap2 and kinesin-14 motor kifc3 control dentritic microtubule Organization revealed that camsap2 and kifc3 of kinesin14 family are involved in the regulation of microtubule structure in neurons.
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How are mammalian circadian rhythms affected? The study found new neuronal subtypes.
Time of Update: 2020-07-22
in this study, we systematically classified the cells in the suprachiasmatic nucleus (SCN), the circadian rhythm center of mice, by using single cell sequencing technology, and found new neuronal subtypes, revealing the differences of gene expression of these cell subtypes in the process of circadian rhythm and light stimulation.
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China University of Science and Technology and other countries have made progress in the study of molecular structure mechanisms in the polar maintenance of nerve cells.
Time of Update: 2020-07-22
On December 30, 2019, the Key Laboratory of membranous organelles and cell dynamics, Ministry of education, National Research Center for micro scale material science, and Professor Dynasty research gr
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Nature: After eating, the intestinal barrier strike is what causes the unexpected ending.
Time of Update: 2020-07-22
These results suggest that VIP neurons may play a key role in the regulation of intestinal immune homeostasis by CCR6 positive ilc3.
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A new way to reveal how HIV affects cognitive function in the brain!
Time of Update: 2020-07-22
In summary, the researchers described three culture methods of microglia, astrocytes and neurons derived from hiPSC, and found that HIV infection can increase eIF2 signal of all three cell types, while EFZ alone can generate inflammatory signal through RNA expression.
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Nature. The time Songhai/Sihang team revealed the anchoring of the central body to regulate the characteristics of the neuroprecursor cells and the formation of the cerebral cortex.
Time of Update: 2020-07-22
The brain is the highest center of the nervous system, which controls such high-level neural activities as perception, movement, language, thinking and cognition. it is very important to study the dev
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Nature. Intestinal flora promotes the excitability of intestinal neural networks to maintain intestinal physiological function.
Time of Update: 2020-07-22
the authors found that the transcription factor aryl hydrocarbon receptor (AHR) as a biosensor of intestinal neural network can sense the microbial environment in intestinal cavity and induce expression, and participate in maintaining the excitability of intestinal neurons and regulating intestinal physiological functions.
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Nat Comm . . . Pan Guangjin group revealed the key role of H3K27me3 demethylating enzyme KDM6 family to regulate human nerve development.
Time of Update: 2020-07-22
in recent years, pan Guangjin research group of Guangzhou Institute of biological medicine and health, Chinese Academy of Sciences has done a series of work on epigenetic regulation in the process of stem cell fate transition.
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The study reveals the pattern and regulation mechanism of fruit fly population aggregation.
Time of Update: 2020-07-22
Recently, Zhuyan laboratory, Institute of Biophysics, Chinese Academy of Sciences, published an online article entitled "emergence of social cluster by collective pairwise encounterers in drophila" in eLife magazine.
