Why does flashing light fight Alzheimer's? It is triggered by the release of signal ingress in the brain.

As early as 2016, studies have found that in mice with Alzheimer's disease, 40 Hz flicker light can activate microglia to clear garbage, thus providing a new way to manipulate the nervous immune system. However, the biochemical signal transduction mechanism is still unknown.researchers at the Annabelle singer laboratory at Georgia Tech recently published an article in the Journal of neuroscience to reveal how the flicker works.through mouse experiments, they found that exposed to 40 Hz light pulses, the brain will release a large number of signal chemicals, which may help to fight diseases.doi: the frequency of 40 Hz is derived from the observation of early brain gamma deficiency in patients with Alzheimer's disease.gamma wave is a kind of mild and continuous brain wave, just like the dance rhythm of neuron activity. Its most common frequency is about 40 Hz, which enables mice to recover gamma rays when exposed to light of this frequency, and can also prevent brain damage caused by severe Alzheimer's disease.in this study, the researchers used multiple immunoassays to search for brain chemicals that associate flicker with microglia and other immune activation in mice, and exposed to a surge of 20 cytokines. It was found that 40 Hz light flicker rapidly and briefly stimulated the phosphorylation signal transduction in the NF - κ B pathway in the visual cortex of mice.after the phosphorylation of NF - κ B, the phosphorylation signal transduction in MAPK pathway was increased, and the expression of various cytokines was increased. These cytokines were involved in the recruitment of microglia (such as M-CSF), neurotrophic characteristics (such as IL-6) and synaptic plasticity (such as IL-1).40 Hz flicker for 1 hour, the expression of cytokines in visual cortex increased. As a control, the researchers also applied three additional light stimuli, which to their surprise, all had certain effects on cytokines.especially at 20 Hz, cytokine levels decrease, which may also be useful in cases where cytokine inhibition is desired.many nervous system diseases are related to immune response, such as Parkinson's disease or schizophrenia, so different kinds of stimulation may become a tool platform in different situations.as a result, the team warned people not to use phototherapy on their own, as more data were needed to thoroughly determine the effects of phototherapy on humans, and the wrong frequency could even cause damage.the researchers demonstrated experimental masks and earphones that can play 40 Hz photoacoustics, and are currently undergoing human testing.Image Source: Georgia Tech / Allison Carter's research results in mice provide information for human trials.researchers have made experimental masks and earphones to play 40 Hz photoacoustics for human testing. As a possible treatment for Alzheimer's disease, the test results will be published in subsequent studies.end reference: [1] flying light mobiles brain chemistry that may fight Alzheimer's