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Cell . . . Zebrafish whole-brain calcium imaging records reveal cerebellum participation in cognitive coding.
Time of Update: 2020-07-22
first of all, the researchers used high-speed volumetric calcium imaging recording technology based on light field microscope to synchronously detect the activity of neural network in the whole brain at the single cell level, and combined with a new type of operating conditioned reflex paradigm based on zebrafish juveniles, tail flick to reduce aversion stimulation (release of aversive stimulus by turn, Toast, Fig. 1) to study the neurobiological mechanism of goal-directed action selection.
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Nature. AIM2 inflammatory small cells affect nervous system development by monitoring DNA damage.
Time of Update: 2020-07-22
next, the authors studied whether the loss of aim2 inflammasome function during the development of nervous system would affect the level of DNA damage in the brain.
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Small glial cells "live swallow" alpha-synaptic nucleoproteins and degrade them by autophagy.
Time of Update: 2020-07-22
the researchers used TLR4 knockout mice to conduct primary culture of microglia and found that p62 protein did not increase and autophagy related degradation was reduced even in the aggregation of α - synuclein.
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Cell . . . How is the pain perceived?
Time of Update: 2020-07-22
On February 20, 2020, Professor Reza Sharif naeini from McGill University of Canada and his collaborators published a report on cell entitled TACAN is an ion channel involved in sensing mechanical Pain's research (this work was published on the preprint website biorxiv in June 2018) reported and named a previously unknown ion channel protein TACAN, which is a pain receptor.
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Nature back-to-back text: "cold" myelin actually participated in memory formation, domestic scientists led the completion.
Time of Update: 2020-07-22
in order to further prove the relationship between myelin sheath and cognitive function, the researchers constructed specific knockout mice: Olig2 is an important transcription factor regulating the differentiation of OPC, which can be specifically knocked out by cspg4creert; MAPT mgfp mice and Olig2 floxed mice, which can inhibit the regeneration of myelin sheath, but does not affect the mature oligodendrocytes.
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Neuron. Xiao Bailong/Li Xueming collaboration reveals the "gate plug and latch" gate dissenion mechanism of the mechanical gated Piezo ion channel.
Time of Update: 2020-07-22
in the latest neuron paper, three lateral ion permeability pathways in the inner side of piezo channel were determined by using site directed mutagenesis based on structural analysis, electrophysiological function of patch clamp and identification of novel shear variants Portal), lateral plug gate (lateral plug gate) that physically blocks the lateral ion permeability path, and latch element (latch) that controls the lateral plug (Fig. a).
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Nature. The direct mechanical sensor of endothelial cells- the guided receptor nerve plexin D1.
Time of Update: 2020-07-22
the authors found that plxnd1 is indispensable for endothelial cells to respond to shear stress in vivo and in vitro, and regulate the specific distribution of atherosclerotic plaque.
in conclusion, plxnd1 in endothelial cells is a direct shear stress sensor and plays an indispensable role in the mechanoreceptor complex.
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Cell . . . How does whole hemp selectively affect the neurons of the cortex vertebral body?
Time of Update: 2020-07-22
first of all, the researchers used photogenetics to induce the depolarization of the distal apical dendrite structure of the L5 vertebral neurons, simulating the feedback signals input to the L1 cortex.
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PNAS: Why "sad people don't listen to slow songs"? New research reveals 13 emotional experiences that music brings.
Time of Update: 2020-07-22
scientists from the University of California studied the emotional reactions of more than 2500 people in China and the United States to 2168 music clips, and summed up 13 cross-cultural emotional experiences: pleasure, joy, pornography, beauty, relaxation, sadness, fantasy, victory, anxiety, shyness, worry, contempt and excitement.
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Cell . . . The neurobiological basis behind the "one-on-one" and "local conditions" of memory.
Time of Update: 2020-07-22
therefore, the researchers believe that Fos and npas4 cells interact with different brain regions in the process of memory formation, leading to different division of labor.
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Why does fruit fly courtship "position" change? New Princeton study: By looking at the neurons behind it, Nature sub-magazine.
Time of Update: 2020-07-22
this study from Princeton University, author Mala Murthy and her team used deep neural network model to successfully predict when and how male flies would sing a "love song" to "heart flies".
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Professor Zhang Lining of Shandong University reveals the role of tumor suppressor PDCD4 in depression.
Time of Update: 2020-07-22
on the other hand, the researchers used AAV virus to specifically overexpress PDCD4 in the hippocampus, which led to depression like behavior in mice even without chronic stress.
the researchers found that BDNF protein expression in hippocampus of wild-type mice was down regulated after chronic stress, but not after PDCD4 knockout.
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The study reveals the pattern and regulation mechanism of fruit fly population aggregation.
Time of Update: 2020-07-22
Recently, Zhuyan laboratory, Institute of Biophysics, Chinese Academy of Sciences, published an online article entitled "emergence of social cluster by collective pairwise encounterers in drophila" in eLife magazine.
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Nat Comm . . . Pan Guangjin group revealed the key role of H3K27me3 demethylating enzyme KDM6 family to regulate human nerve development.
Time of Update: 2020-07-22
in recent years, pan Guangjin research group of Guangzhou Institute of biological medicine and health, Chinese Academy of Sciences has done a series of work on epigenetic regulation in the process of stem cell fate transition.
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Cell Sub-journal: Bin1 protein, the second leading risk factor for late-onsis AD, is also the key to the integration of spatial memory in the brain!
Time of Update: 2020-07-22
To sum up, this study emphasizes that: 1) the loss of Bin1 in neurons may damage the spatial memory integration function of the brain; 2) neuronal Bin1 regulates the release of presynaptic neurotransmitters The excitatory synaptic transmission in cKO mice is defective; 3) BIN1 can regulate the release of presynaptic vesicles in hippocampal excitatory synapses; 4) emphasizes the non redundant role of BIN1 in presynaptic regulation.
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Cell . . . Significant developments are expected to help blind people regain their vision.
Time of Update: 2020-07-21
In order to make visual cortex prosthesis better help blind people understand the world, Professor Daniel yoshor started to develop dynamic activated electrodes.
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A pound of food?! British scientists have discovered brain cells that cause appetite to soar.
Time of Update: 2020-07-21
previous studies have found that extensor cells are mainly distributed in the hypothalamus, the area of the brain responsible for energy control.
DOI: Tanycytes in the brain play an active role in increasing appetite.
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Science: Terrible! T-cell mitochondrial dysfunction causes premature aging and a variety of diseases.
Time of Update: 2020-07-21
these results suggest that tfam-cd4 knockout mice exhibit metabolic, phenotypic and functional characteristics of aging T cells.
researchers found that there were a large number of inflammatory factors in the peripheral of tfam-cd4 knockout mice, which showed the characteristics of aging inflammation.
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Cell Sub-Journal: Reveals the neural loop that boosts appetite after eating fat meat.
Time of Update: 2020-07-21
in general, we found that PNOC neurons promote excessive diet after acute high-fat diet, which provides a new goal for the prevention and treatment of obesity and related metabolic diseases.
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Nature Neuroscience. Detailed interpretation, found that the regulation of "eating" neurons were also involved in the control of "fighting" behavior.
Time of Update: 2020-07-21
confirmed that LHB oxr2 mediates the increase of gad2 + neuronal activity in aggressive behavior.
the authors confirmed that orexin neurons in the lateral hypothalamus (LH) activated LHB gad2 + and mediated aggressive behavior.
