Nature has made significant progress. Old and not old! Cai Shiqing/Jiang Lubin discovered its potential molecular mechanism.

Inature has long been believed that there is a strong correlation between longevity and healthy longevity, but the two can be clearly separated.although life expectancy has increased worldwide, life expectancy is rarely accompanied by an increase in health.therefore, it is still an important and challenging task to understand the origin of health behaviors of the elderly.on February 26, 2020, Cai Shiqing, Shanghai Institute of neurobiology, Chinese Academy of Sciences, and Jiang Lubin of Pasteur Institute jointly published a research paper entitled "two conserved epigenetic regulators prevent health aging" online in nature. The research shows us the possibility of realizing "healthy aging".through genome-wide gene screening, 59 genes were identified as potential regulators of age-related behavior deterioration rate.among these regulatory proteins, the researchers found that the neuronal epigenetic recognition protein baz-2 and the neurohistone 3 lysine 9 methyltransferase set-6 accelerated the deterioration of nematode behavior by reducing mitochondrial function and inhibiting the expression of nuclear encoded mitochondrial protein.this mechanism is conserved in cultured mouse neurons and human cells.examination of the human database showed that the expression of these human ortho homologs of Caenorhabditis elegans regulatory proteins baz2b and ehmt1 increased with age in frontal cortex, and was positively correlated with the progression of Alzheimer's disease.in addition, the deletion of baz2b, the mouse lineal homologue of baz-2, attenuated age-related weight gain and prevented cognitive decline in aging mice.therefore, the whole genome RNA interference screening in Caenorhabditis elegans revealed the conservative epigenetic negative regulatory proteins of aging, and suggested a possible way to achieve healthy aging.for a long time, people have thought that there is a strong correlation between life expectancy and healthy life span, but they can be clearly separated.although life expectancy has increased worldwide, life expectancy is rarely accompanied by an increase in health.therefore, it is still an important and challenging task to understand the origin of health behaviors of the elderly.here, the researchers report on the conservative epigenetic mechanism of healthy aging.through genome-wide RNA interference based gene screening, the researchers identified 59 genes as potential regulators of age-related behavior deterioration rate.among these regulatory proteins, the researchers found that the neuronal epigenetic recognition protein baz-2 and the neurohistone 3 lysine 9 methyltransferase set-6 accelerated the deterioration of nematode behavior by reducing mitochondrial function and inhibiting the expression of nuclear encoded mitochondrial protein.this mechanism is conserved in cultured mouse neurons and human cells. examination of the human database showed that the expression of these human ortho homologs of Caenorhabditis elegans regulatory proteins baz2b and ehmt1 increased with age in frontal cortex, and was positively correlated with the progression of Alzheimer's disease. in addition, the deletion of baz2b, the mouse lineal homologue of baz-2, attenuated age-related weight gain and prevented cognitive decline in aging mice. therefore, the whole genome RNA interference screening in Caenorhabditis elegans revealed the conservative epigenetic negative regulatory proteins of aging, and suggested a possible way to achieve healthy aging. reference message: