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Study of Nervous System

Nature: Over the course of eight years, Yuan's team has provided a new direction for the treatment of neurodegenerative diseases in humans.

 Time of Update: 2020-10-05

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The study successfully screened the small molecular compound Apostatin-1, which inhibits both cell death and activates autophagy, and identified its target TRADD protein, further confirming that targeting TRADD is very safe, an eight-year effort that provides a new direction for treating neurodegenerative diseases in humans.
Huashan Chen Tojun, Bohai: Sinimod brings the cutting-edge therapy to patients with multiple sclerosis in China, and the development of new drugs can be breakthrough in four directions.

 Time of Update: 2020-10-05

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Multiple Sclerosis, MS) is an autoimmune neuro-inflammatory disease caused by the immune system "out-of-control" immune cells to attack the central nervous system, resulting in myelin damage to the ce
Nat Neurosci: The loss of the surface genomics analysis of neurons in Parkinson's disease has a neuropersonal protective effect.

 Time of Update: 2020-10-05

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PD clinical characteristics, such as delay in the age of onset of the disease, low consistent rate among single-egg twins (11%), fluctuations in symptoms during the course of the disease, manifestations of one- to two-sided symptoms in most people (85%)3 and significant risk of gender differences in the disease, together indicate the contribution of the alterable apparent genome to the origin and progression of the disease.
Acta Neuropathologica: IL-1 promotes autoimmune neuroinflamed by inhibiting hemoglobin oxytocin-1 in the hemoglobin-1 of the blood-brain barrier.

 Time of Update: 2020-10-05

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the mechanism, our data emphasize the functional crosstalk of BBB-EC IL-1 signals and HO-1, and control the transcription of downstream inflammatory genes, thus promoting the pathogenesis of autoimmune neuroinflamm.
JNNP: Lacosaamine therapy aids the efficacy and safety of primary systemic strong-frontal epilepsy: a double-blind, randomized, placebo-controlled trial.

 Time of Update: 2020-10-05

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The treatment of myoclonic seizures and primary systemic strong-straight seizures (PGTCS) in patients with IGE is complex, as certain anti-epileptic drugs (AEDs) may aggravate the associated type of seizure, such as arrhythmic or myoclonic seizures.
Acta Neuropathologica: In the MS model, TREM2 activation on small glial cells promotes myelin fragment removal and myelin re-formation.

 Time of Update: 2020-10-05

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treatment with a new TREM2 exciter antibody promotes the removal of myelin fragments in cnS demyelination models, including by facilitating the absorption and degradation of myelin, thereby accelerating the removal of myelin fragments by small glial cells.
Acta Neuropathologica: Coarse-grained plaques: a different type of A-beta plaque in early-haired Alzheimer's disease.

 Time of Update: 2020-10-05

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longer A-beta-42 is more likely to accumulate, mainly in the brain's essential plaques, while the shorter A-beta-40 is secreted by higher-level cells and is the main A-beta subtype deposited in the cerebrovascular system, known as cerebral amyloid vascular disease (CAA).
Alzheimer's and Dementia: iSTAGING Alliance: Machine learning reveals links between brain aging, whiteness disorders, amyloid protein burden and cognition.

 Time of Update: 2020-10-05

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Most recently, researchers studied the relationship between typical aging brain atrophy patterns and Alzheimer's disease (AD), white disease, cognition, and AD neuropathology through machine learning in a large, unified magnetic resonance imaging database (11 studies; 10,216 subjects).
Am J Clin Nutr: If you want to have a good memory, drink more pomegranate juice.

 Time of Update: 2020-10-05

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the baseline variables of 98 pomegranate juice groups and 102 placebo group subjects who completed the study were not significantly different. , the results showed that drinking pomegranate juice daily stabilized the ability to learn visual information for 12 months.
Alzheimer's and Dementia: Target app, Posiphen can treat Down syndrome.

 Time of Update: 2020-10-05

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The results support the APP gene dose hypothesis, and more research is needed to explore the mechanisms by which APP gene expression increases the risk of AD in DS, as well as the possible effects of treatments that normalize the level of APP and its products to prevent the onset of AD in DS patients." important unanswered questions in the study: 1.
Proc Natl Acad Sci U S A: Unlike adults, children use two hemispheres of the brain to understand the function of performing language.

 Time of Update: 2020-10-05

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The language regions of the left and right hemispheres of the brain (LH and RH) in the youngest children (4 to 6 years old) showed significant activation, however the proportion of participants with significant RH activation decreased with age, with more than 60% of adult participants not showing any significant RH activation.
Stroke: Electro-encephalograms may improve the diagnosis of acute stroke and large vascular closure.

 Time of Update: 2020-10-05

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patients who were treated in the emergency department and were suspected of acute stroke (n-100) were clinically examined and then electroencephalograms were performed using a dry electrode system.
JAMA Netw Open: A new study by a team of Chinese scientists suggests that sleeping too much, or too little, is associated with cognitive decline.

 Time of Update: 2020-10-05

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In the new study, the team used two nationally representative cohorts, the British Longitudinal Study of Ageing (ELSA) and the China Health and Pension Tracking Survey (CHARLS), to explore the relationship between baseline sleep length and subsequent cognitive decline rates in middle-aged and older people.
New drug for acute treatment of migraines! Axsome's new oral multi-mechanism drug, AXS-07 Phase III, has significantly better clinical efficacy than Liza tuptan!

 Time of Update: 2020-10-05

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, the company announced that its new oral multi-mechanism drug, AXS-07, rapidly relieves migraines and significantly reduces recurrence in the Phase III MOMMENTUM trial of acute migraine treatment: compared to the active controlled drug rizatriptan.
Doctor's Day benefits draw! Whose home does Coke fall all year round?

 Time of Update: 2020-10-05

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AGING CELL: The team found that the longevity gene Klotho improves the removal and cognition of A-beta in Alzheimer's disease.

 Time of Update: 2020-10-05

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studies have shown that A-beta activates NACHT, LRR, and PYD-containing protein 3 (NLRP3) inflammatory bodies, mediates the transition of small glial cells from M2 to M1, reducing the removal of A-beta.
Nature: The maternal microbiome regulates fetal neurodevelopment.

 Time of Update: 2020-10-05

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use specific bacteria to plant missing female mice in the microbiome to prevent abnormalities in fetal brain gene expression and cerebral cortogenic axons. , the results suggest that the maternal gut microbiome promotes fetal cerebral cortical axons, possibly by sending signals to neurons in brain development through metabolites regulated by microorganisms.
JAHA: Screening for extracranial systemic artery disease in young people with smoke disease.

 Time of Update: 2020-10-05

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researchers performed coronary arteries and aortic CT angiogenesic tracts to summarize the characteristics of extracranial arterial lesions and explored the correlation between their clinical characteristics and MMD status, including the RNF213 p.Arg4810Lys mutation (c.14429G-Gt;A, rs112735431).
How can Alzheimer's disease, an incurable disease, be prevented?

 Time of Update: 2020-10-05

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Studies have shown that a healthy lifestyle can help reduce the risk of developing dementia later in life. 5 Social participation is good for the brain and helps reduce the risk of dementia and depression.
DC2020: Li Zi pay, cerebrovascular interventional treatment progress.

 Time of Update: 2020-10-05

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This year, the Forum to "pick up the grade, the new journey" as the theme, continue to pay attention to China's medical device industry ecological development, the latest changes in industry policy; on September 18th, Li Zihua, deputy director of Shanghai Changhai Hospital, delivered a speech on the theme of "Progress in Cerebrovascular Interventional Therapy".

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Study of Nervous System

Nature: Over the course of eight years, Yuan's team has provided a new direction for the treatment of neurodegenerative diseases in humans.

Huashan Chen Tojun, Bohai: Sinimod brings the cutting-edge therapy to patients with multiple sclerosis in China, and the development of new drugs can be breakthrough in four directions.

Nat Neurosci: The loss of the surface genomics analysis of neurons in Parkinson's disease has a neuropersonal protective effect.

Acta Neuropathologica: IL-1 promotes autoimmune neuroinflamed by inhibiting hemoglobin oxytocin-1 in the hemoglobin-1 of the blood-brain barrier.

JNNP: Lacosaamine therapy aids the efficacy and safety of primary systemic strong-frontal epilepsy: a double-blind, randomized, placebo-controlled trial.

Acta Neuropathologica: In the MS model, TREM2 activation on small glial cells promotes myelin fragment removal and myelin re-formation.

Acta Neuropathologica: Coarse-grained plaques: a different type of A-beta plaque in early-haired Alzheimer's disease.

Alzheimer's and Dementia: iSTAGING Alliance: Machine learning reveals links between brain aging, whiteness disorders, amyloid protein burden and cognition.

Am J Clin Nutr: If you want to have a good memory, drink more pomegranate juice.

Alzheimer's and Dementia: Target app, Posiphen can treat Down syndrome.

Proc Natl Acad Sci U S A: Unlike adults, children use two hemispheres of the brain to understand the function of performing language.

Stroke: Electro-encephalograms may improve the diagnosis of acute stroke and large vascular closure.

JAMA Netw Open: A new study by a team of Chinese scientists suggests that sleeping too much, or too little, is associated with cognitive decline.

New drug for acute treatment of migraines! Axsome's new oral multi-mechanism drug, AXS-07 Phase III, has significantly better clinical efficacy than Liza tuptan!

Doctor's Day benefits draw! Whose home does Coke fall all year round?

AGING CELL: The team found that the longevity gene Klotho improves the removal and cognition of A-beta in Alzheimer's disease.

Nature: The maternal microbiome regulates fetal neurodevelopment.

JAHA: Screening for extracranial systemic artery disease in young people with smoke disease.

How can Alzheimer's disease, an incurable disease, be prevented?

DC2020: Li Zi pay, cerebrovascular interventional treatment progress.