JAHA: Screening for extracranial systemic artery disease in young people with smoke disease.

RNF213 is the main susceptible gene for smog disease (MMD), characterized by chronic intracranial artery stenosis.
, extracranial arterial lesions occur occasionally in a small number of cases and in children with MMD.
A recent study published in JAHA, an authoritative journal in the field of cardiovascular disease, looked forward to recruiting 63 young adults (aged 20-49) with no history of systemic angiopathy, which, according to typical angiology, has been diagnosed (double-sided, n-54) or possibly (one-sided, n-9) MMD.
researchers performed coronary arteries and aortic CT angiogenesic tracts to summarize the characteristics of extracranial arterial lesions and explored the correlation between their clinical characteristics and MMD status, including the RNF213 p.Arg4810Lys mutation (c.14429G-Gt;A, rs112735431).
11 (17%) of the 63 patients had significant stenosis in coronary arteries (n=6), intestinal membrane arteries (n=2), abdominal aorta (n=2), renal arteries (n=1) and/or intrial arteries (n=1).
patient is accompanied by both the intestinal membrane and the artery stenosis in the thyroid.
are more likely to have diabetes and suffer from back artery injuries.
, a higher prevalence of aneurysm disease (67 percent of pure throossis) was observed in individuals with RNF213 p.Arg4810 Lys mutations.
after adjusting for diabetes and back-of-brain artery injury, the p.Arg4810Lys mutation was independently associated with extracranial arterial lesions (added model; P=0.035; adjusted ratio of 4.57; 95% CI was 1.11-27.20).
this, MMD young people may be accompanied by extracranial artery lesions in various locations.
should be screened for systemic artery disease in individuals with RNF213 mutations, especially p. Patients with Arg4810Lys pure mutation.
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