Nature: The maternal microbiome regulates fetal neurodevelopment.

The microbiome is an important regulator of brain function and behavior.
previous studies have shown that animals that do not have microbial sterile (sterile, GF) or depleted microbiomes (antibiotic treatment, ABX) exhibit neurophysiological and behavioral changes compared to normal animals without specific pathogens (SPF).
, only a subset of verteomes can be corrected by postpartum recovery of the microbiome, indicating that the maternal pregnancy microbiome is involved in regulating the development of brain function and behavior in adulthood.
fact, the gut microbiome is necessary to address maternal challenges such as immune activation, high-fat diets and psychosocial stress, which induce neurobelitic abnormalities in mice.
However, to this day, it remains unclear whether the effects of this microorganism on neurodevelopment originated prenatally, by disrupting the function of the maternal microbiome, and/or by changing the neonatal microbiome through vertical transmission after birth.
Addition, although studies have shown that the maternal microbiome can regulate the host's response to acute stress, it remains unclear whether it affects the development of future generations in the absence of environmental challenges.
Recently, researchers published a paper in the journal Nature that explored the role of the maternal gut microbiome in regulating early embryonic brain development and late-stage offspring behavior during steady-state processes by studying the effects of depleted and selectively reconstructed maternal gut microbiomes on fetal neurodevelopment in mice.
researchers found that embryos from antibiotic-treated female and sterile female mice showed reduced brain expression of genes associated with axons, loss of cerial cortial axons, and impaired growth of cerial axons under the influence of extracellular factors.
use specific bacteria to plant missing female mice in the microbiome to prevent abnormalities in fetal brain gene expression and cerebral cortogenic axons.
of the maternal metabolic group showed that the maternal microbiome regulates many small molecules in the maternal serum and fetal brain.
specific microbiome-dependent metabolites can promote the growth of fetal mascuroid axons.
addition, maternal supplementation of these metabolites can eliminate fetal dendy brain axon defects.
Manipulating the maternal microbiome and microbial metabolites during pregnancy resulted in changes in the tactile sensitivity of adult offspring in two aversion-to-body behavioral tasks, but there was no significant difference in many other sensory motor behaviors.
, the results suggest that the maternal gut microbiome promotes fetal cerebral cortical axons, possibly by sending signals to neurons in brain development through metabolites regulated by microorganisms.
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