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Nature: Significant progress! It is revealed that eIF2 alpha enhances long-term memory by stimulating protein synthesis in inhibitory neurons.
Time of Update: 2020-10-23
However, co-author Dr Jean-Claude Lacaille, of the University of Montreal, said: 'We also found that stimulating a specific class of inhibitory neurons ---tra-growth inhibitor intermediate neurons --- through eIF2 alpha is also sufficient to enhance long-term memory by adjusting the plasticity of neuron connections." Sharma added, "It is fascinating to be able to confirm that these new participants ---insuppressive neurons--- play an important role in memory consolidation.
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Autophagy: Key enzyme defects cause brain cell death.
Time of Update: 2020-10-23
"At the beginning of the study, researchers, including lead author Dr. Cenxiao Fang, knew that, with the removal of bad mitochondrials, the TBK1 enzyme activates p62 by adding phosphorylation modifications to the p62 protein 403 serine (SER403).
(bioon.com) Source: Enzyme SSH1 Impairs disposal of accumulating cellular garbage, leading to brain cell death Source: Autophagy (2020).
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New drug for idempable narcolepsy! Unique cation hydroxybutyric acid therapy Xywav (calcium hydroxybutyrate magnesium potassium sodium) Phase 3 clinical success!
Time of Update: 2020-10-23
Oct 11, 2020 // -- Jazz Pharmaceuticals recently announced positive top-line results for evaluating Xywav (sodium hydroxybutyrate, potassium, magnesium, calcium, JZP-258) oral solution for the treatment of idiopathic hypersomnia (IH) adult patients.
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Brain: Scientists have revealed a molecular link between inflammation and Parkinson's disease.
Time of Update: 2020-10-23
12, 2020 // -- In a recent study published in the international journal Brain, scientists from the University of Luxembourg and other institutions revealed a link between inflammation and specific gen
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Nature: New role! Small glial cells may effectively regulate the function and behavior of neurons in the brain!
Time of Update: 2020-10-23
In the future, researchers will identify new signaling molecules such as ATP, which will promote the function of small glial cells to regulate highly diverse neurons, including those that control sleep or the body's metabolism, and the results of this paper will help researchers better understand the fine molecular mechanisms of neuromodulation in the body's brain.
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Innovative medicine for acute migraines! Nasal drug methyl sulfonate dehydroamine (DHE) INP104:15 minutes effective, 2 hours to relieve pain!
Time of Update: 2020-10-23
INP104 uses Imple's propulsion POD technology to easily and consistently deliver the optimal dose of DHE to the blood vessel-rich upper nasal cavity, which is an ideal target for effective administration, especially for most migraine patients, nausea and/or vomiting during seizures, which limits the use of oral therapies, including quentin, calcitonin gene-related peptides (CGRP) inhibitors, tetanus, and other nonstopic acute migraine drugs.
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The study revealed abnormal brain structure connections and functional connections in people with high schizophrenic traits.
Time of Update: 2020-10-23
Chen Chuyu, a researcher at the Mental Health Key Laboratory of the Institute of Psychology of the Chinese Academy of Sciences and a researcher in the Applied Cognitive Neuroscience Laboratory, and his team examined changes in brain structure and functional connections associated with schizophrenic traits.
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J Neurosci: Excessive accumulation of tau protein is present in areas of the brain that are blocked by blood flow.
Time of Update: 2020-10-23
(Photo: www.pixabay.com) As Alzheimer's progresses, vascular function declines and β-amyloid and tau proteins accumulate, leading to neuron death.
(bioon.com) Source: Brain regions with impaired blood flow have higher tau levels Original source: JNeurosci (2020).
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EMBO Rep: Study reveals how brain elasticity is made.
Time of Update: 2020-10-23
results show that microRNA family miR-29 is an age-dependent regulator for the plasticity of the development of the visual cortical layer.
, studies have shown that miR-29a is an important regulator for plastic fractures that promote the stability of age-related visual cortical connections.
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Acta Neuropathologica: Damage to mitochondrial carbon metabolic enzyme SHMT2 causes a new type of brain and heart development syndrome.
Time of Update: 2020-10-22
enzyme located at the intersection of amino acid and folic acid metabolic pathways is SHMT2, a mitochondrial form of serine hydroxymethyl transferase.
although the severity varys to some extent, the clinical manifestations of all individuals are consistent, creating a clear and identifiable clinical syndrome of metabolic defects in folic acid and amino acids.
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The study found that the lipid solution of nerve cells promotes the degeneration of nerve cells.
Time of Update: 2020-10-22
The study found that regulating polyunsaturated fatty acid levels and their balance between triglycerides and phospholipids can affect neurocellular degeneration caused by overactivation of ion channel proteins, which is of guiding significance for the treatment of neurodegenerative diseases.
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Curr Biol: New results in intestinal and brain axis research! Scientists have revealed the molecular mechanisms by which stomach hunger affects the body's brain memory!
Time of Update: 2020-10-22
In order to delve deeper into the molecular mechanisms of stomach hunger that affect the body's hunger, metabolism, and memory, the researchers studied the interaction between gastric hunger hormone and the mesmerized nerve, a nerve that sends signals from the intestines to the brain, and then monitored the effects of interference between gastric hunger hormone and the ecstrain nerve on the body's eating and cognitive behavior.
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New migraine medicine! Nurtec ODT enters review in the U.S.: the first CGRP targeted drug to be proven to be effective in both acute and preventive treatments!
Time of Update: 2020-10-22
October 15, 2020 // -- Biohaven Pharmaceuticals has announced that the U.S. Food and Drug Administration (FDA) has accepted Nurtec ODT (Rimegepant, 75mg) application for a new supplement (sNDA) for preventive treatment of migraines.
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Botulinum toxin treats neck dystia! DaxibotulinumtoxinA Phase 3 clinical success, Fosun Pharma introduced to China development!
Time of Update: 2020-10-22
Revance expects the results of another parallel Phase 3 open-label, long-term safety clinical trial, ASPEN-OLS, to be available in 2021, with 354 subjects in the group.
() Origin: Revance Reports Positive Results from ASPEN-1 Phase 3 Trial of DaxibotulinumtoxinA for Injection in Cervical Dystonia.
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Mol Psych: Study reveals STAT3 helps regulate mood.
Time of Update: 2020-10-22
in a study published in the journal Molecular Psychic, MedUni Vienna researchers led by Daniela Pollak of the Department of Neurophysiology and Neuropynamics showed that STAT3, a molecule that controls emotional responses, plays an important role in transmitting 5-serotonin-related signaling systems.
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Nat Commun:IL-33 promotes the establishment of tumor micro-environments and accelerates the development of gliomas.
Time of Update: 2020-10-21
addition, nuclear-positioned and secretion-type IL-33 regulates a number of degeneration factors that promote the formation of tumor micro-environments by co-recruiting and activating inherent immune cells.
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350 million people around the world are suffering from TA! This disease, you and I may have.
Time of Update: 2020-10-21
Recently, japan's famous actress Takeshi Takei was found dead at home aged 40, Japanese police initially concluded that suicide also has news suspected that the next birth of the next son of Takeshi k
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JNNP: Serum IgG anti-GD1a antibodies and mEGOS predict the prognosis of Green-Barre syndrome.
Time of Update: 2020-10-21
, the combined application of serum IgG antibodies between mEGOS and anti-neurososide lipids was also studied to help predict poor prognosis.
, 80% of patients had serum IgG anti-GD1a antibodies and high mEGOS≥10 on the 7th day of hospitalization, with poor prognosis.
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Acta Neuropathologica: Familial adenoma pheosarcoma-related craniofacial tube tumors are secondary to APC gene lineage and somatic cell mutations.
Time of Update: 2020-10-21
the CTNNB1 gene (MIM x 116806, serial protein β-1) of most meningococral cranial pharyngopharyngeal tumors (ACs) mutates, resulting in the build-up of β-link proteins and activation of the Wnt signaling path.
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Sci Adv: Why is drinking addictive? Alcohol alters the shape of the extracellular space in the brain and the spread of the medium in the brain.
Time of Update: 2020-10-21
The study demonstrates that long-term chronic drinkers and rats increase the diffusion rate of the brain's gray matter extracellular space (ECS) over time, which in turn gradually increases the concentration of neurotransmitters such as dopamine, a combination that may be a new mechanism of alcohol addiction.
