350 million people around the world are suffering from TA! This disease, you and I may have.

Recently, japan's famous actress Takeshi Takei was found dead at home aged 40, Japanese police initially concluded that suicide also has news suspected that the next birth of the next son of Takeshi knot may be due to postpartum depression suicide mention depression what would you think? Bad mood or "you just think too much" However, the real situation is based on WHO data from the point of view of burden-causing depression has become the second largest human "disease burden" more serious according to WHO forecast that by 2030, depression will rise to "human disease burden" first in September, the National Health And Wellness Commission Office issued "exploring the special services of depression prevention and treatment work program" from the national level to send a clear signal to the public - depression is not simple "low mood" it is A disease that needs to be detected and intervened as early as possible with the release of this document "high school students, college students will be screened for depression" rushed to the hot topic October 10 is the theme of this year's World Mental Health Day is "promoting anti-epidemic spirit, protect mental health" for each of us ordinary people perhaps the first step should be to correctly understand that mental health depression is a high rate of mental illness, but less than 10% I think this life is over.
" in early August, Xiao Li (analyte) in the company of his mother walked into Zhejiang University Medical College affiliated with the first hospital mental health clinic, after saying this sentence, he refused to speak again.
It is understood that Xiao li is an international high school senior graduates, from an early family are working hard for him to go abroad to college, his parents are strict with him, he is also very demanding of himself, the target of an Ivy League school in the United States.
, in the third year of high school, the new crown pneumonia epidemic ravaged the world, especially the United States has become a disaster area.
xiaoli's way out of the country suddenly became bumpy.
Because he has been preparing for going abroad for a long time, he can not go back to participate in the domestic college entrance examination, Xiaoli appeared serious weariness, unwilling to speak, often locked himself in the room, lying in bed is most of the day.
xiaoli's parents are also very confused and anxious, not to know how to help Xiaoli.
examination, Xiaoli has been suffering from moderate depression.
"Why are more and more people suffering from depression now?" This is closely related to the rapid development, rapid change and great pressure of modern society.
Hu Shaohua, director of the mental health department of Zhejiang University Hospital, said, "This is not only a medical problem, but also a social public health problem."
" youth, maternal, elderly groups, high-pressure occupation, which is the National Health And Wellness Commission Office issued the "exploration of depression prevention and treatment of special services work programme" focused on the population, these people's depression screening included in the medical examination project.
this is also the current high-risk group of people suffering from depression, and these four states not only cover the different stages of life that almost everyone has to go through, but also involve our parents, children, loved ones, friends and family.
Living in this ever-changing era, everyone can't avoid all kinds of stress, and people in these four states, people may face the most pressure: for teenagers, they face heavy schoolwork, parents' expectations, the future of the unknown; Contradictions; for high-stressed people, fierce competition in the workplace, 35-year-old magic spells, rising path is not smooth, so that they "pressure mountain", the elderly, because of the decline of physical ability, this is prone to insomnia, fatigue and other conditions, a variety of new technologies are endless, there are a number of elderly people away from home, in unfamiliar cities bear the heavy pressure of raising grandchildren.
There are an estimated 350 million people worldwide suffering from depression, and there are more than 95 million people suffering from depression in our country, however, due to various misperviews and perceptions, less than 10% of depression patients in the country seek treatment, more patients become silent majority, day after day suffering from "emotional black dog".
In addition to persistent low mood, they may also have mental retardation, decreased will activity, cognitive dysfunction, physical discomfort, sleep disorders, sexual dysfunction, eating disorders and other symptoms, if not timely intervention, the disease is likely to continue to worsen, serious patients will produce pessimism and even suicide attempts and behavior.
It's not just the "emotional cold" that no one has absolute immunity to" Depression is a high-risk mental illness with a lifetime prevalence rate of 6.8 percent, so no one has absolute immunity to depression.
Professor Hu Shaohua said, "Depression is related to a person's personality, but not that a person's cheerful extroverts, will not get depression, which is the biggest misconception about depression, personality characteristics only determine the risk of depression."
" causes and pathogenesis of depression, traditionally there are two main hypothreassits, one is the hypothesis of stress: patients under constant stress stress, their adrenal corticosteroids continue to secrete glucosol (also known as stress hormones), long-term low levels of glucoticoids lead to the brain sea Horse neuroplasticity decreased, nerve decreased, a monoamine-type delivery hypothesis: the patient's brain 5 serotonin, dephetamine, dopamine and other monoamine-type delivery levels are low, and these monoamine-type delivery is to maintain the body's mood and vitality of important substances.
years, more new pathological mechanisms of depression have attracted the attention of the world scientific community.
In 2018, Hu Haixuan, a double professor in the Department of Mental Health at the First Hospital affiliated with Zhejiang University School of Medicine, published his team's findings on the pathogenesis of depression in the journal Nature: the formation of depression is closely related to the abnormal discharge (cluster discharge) of the external nucleic neurons, the anti-reward center in the brain.
Although there are many hypothetics, it can be confirmed that depression is the result of physiological, psychological and environmental factors, among which, genetics, neuroendocrine, neuroimmune, personality characteristics, psychosocial factors are closely related to the onset of the disease, not just a simple "character" problem.
" is a way of comparing depression to an emotional cold, which confirms that depression is a disease, not just a 'feeling' or a 'bad mood'.
" Professor Hu Shaohua said: "But this statement is not completely correct, colds can heal themselves, but depression is not the same, most depression, especially in moderate to severe patients are difficult to self-heal, irregular diagnosis and treatment may cause chronic and difficult to treat."
many people will feel that people with depression should rely on 'tough willpower to come out on their own', which is the second common misconception about depression.
" but in reality, timely discovery of depression does have some difficulty, on the one hand, some patients do not realize that they have suffered from depression, on the other hand, due to other people's vision or social pressure, depression patients may "actively hide" their condition.
In addition, we should also pay attention to distinguish between depression and depression, in general, depression has the following typical characteristics: depression mood or sadness for once liked activities lost interest or pleasure suddenly or recently weight gain or weight loss or appetite change in insomnia or drowsiness or irritability or speech and exercise Slow fatigue or loss of energy feel worthless or guilty of difficulty concentrating or making decisions often thinking of death or suicide, planning suicide or attempted suicide "if you find yourself or find someone close to you for more than two weeks with these symptoms, and seriously affect social functions, including study, work, socialization, etc., it is recommended to seek medical attention as soon as possible."
Professor Hu Shaohua said, "But these are just some of the more common symptoms of depression, it is possible that some people with depression to 'hide' themselves deeper, which requires people around them to carefully find that, in general, if someone's way of speaking, behavior suddenly changed and continued for a period of time, it is necessary to arouse vigilance."
" after systematic scientific treatment of more than 70% of patients with depression can be cured or effectively controlled as most diseases, depression also has from mild to moderate to severe development process, the significance of early detection is that patients with depression are still in mild symptoms can be timely intervention, if the development to moderate to severe, treatment will be much more difficult, and the probability of recurrence will increase.
The good news is that for people with depression, most of them can be cured or effectively controlled as long as they are treated by the scientific system, and current treatments for depression include medication, psychotherapy, physiotherapy (neurodevestial techniques) and so on.
"For patients with mild depression, we mainly start with psychotherapy.
" Professor Hu Shaohua said, "For patients with moderate and severe depression, we must first take medication or physiotherapy, wait until most of the symptoms improve and then cooperate with psychotherapy."
present, the Department of Mental Health of Zhejiang University hospital is carrying out international advanced neuro-navigation transcranial magnetic stimulation (rTMS) and transcranial direct current electrical stimulation (tDCS) and other new neuro-regulation techniques for patients with depression.
" the current mainstream role of depression drugs to enhance the body's dopamine, 51 serotonin and other hormones, the effective rate of the first drug can reach 60% to 70%, but in the clinic about 20% to 30% of depressed patients are "refrectable depression", may need to be combined medication, or add added to the effects.
study of the pathogenesis of depression has also made it possible to develop more effective drugs.
Currently, the team of Professor Hu Haixuan of Zhejiang University is conducting research that translates research results into clinical applications, which have found that ketamine can block abnormal discharge of nucleic neurons, but because ketamine is addictive, the team is experimenting with a safe drug instead of ketamine, in the mechanism to achieve the same effect, play an effective antidepressant role.
" to be specifically proposed is that patients take drugs, do not because they feel good on their own to stop the drug, or to carry out a re-diagnosis, after the doctor's professional judgment for consolidation of treatment.
Professor Hu Shaohua said, "Depression is a high recurrence of the disease, according to the study, the first episode of depression, the probability of recurrence is about 50%, if the recurrence of two times, the probability of recurrence is as high as 90%, almost 100% relapse."
And scientific system of treatment can greatly reduce the recurrence rate, more than 70% of patients can be cured or effectively controlled, so in the event of depression, it is recommended to seek medical attention immediately, and after a doctor's professional judgment, can stop treatment.
" like Xiao Li, he is a perfectionist child, his family's whole atmosphere is the same, coupled with the outbreak of this major emergency has had a huge impact on his life planning.
that while we are using drugs on him, we use mindthring therapy to re-stimulate his interest in life and sense of value in life.
" Professor Hu Shaohua said, "but also from his family to change his family atmosphere, family, friends of the understanding and tolerance of people with depression is very important."
" after systematic treatment, Xiaoli has greatly improved, and re-established the goal of life - to find schools in Singapore or other countries, the family also reduced the requirements for Xiaoli, no longer demand him "everything must be perfect."
, experts also stress that for people with depression, terms such as "you don't think so much" "everything's going to be okay" and "how can you think that way" are not only dissuasive, but may exacerbate the condition.
The most important thing for people with depression is to understand and share their feelings, to understand that they are indeed "sick", not simply "in a bad mood", to get them to see a doctor in a timely manner, if for patients with severe depression, it takes 24 hours to accompany them to avoid self-harm or suicide.
" People's awareness of depression is still rising, and over the years there will be people with depression, anxiety and other emotional problems who may not be part of the 'disease', but if left to develop, it is likely to eventually progress to depression or anxiety.
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