Mol Psych: Study reveals STAT3 helps regulate mood.

October 16, 2020 /--- A number of scientific studies have shown that inflammatory processes play a key role in the development of mental illness.
areas of particular interest to us, the IL-6/STAT3 signal transduction pathway, which is associated with depression, schizophrenia and bipolar disorder.
in a study published in the journal Molecular Psychic, MedUni Vienna researchers led by Daniela Pollak of the Department of Neurophysiology and Neuropynamics showed that STAT3, a molecule that controls emotional responses, plays an important role in transmitting 5-serotonin-related signaling systems.
STAT3 signal transducting pathway is activated by a series of immunogenic and non-immunogenic stimuli, i.e. stimuli that can and cannot trigger an immune response.
found that STAT3 is involved in neurological function, which is important for controlling behavior in physiological and pathological situations.
in an earlier study, we managed to prove that STAT3 also regulates the expression of the 5-serotonin transport protein gene," Pollak explained.
(Photo source: www.pixabay.com) Serotonin can transmit changes in the use of 5-serotonin as a messenger substance to transfer information from one neuron to another, closely related to pathological changes in depression or other affective disorders.
, however, the interaction between the STAT3 signal transductive pathway and the flow of neuron information in the brain and its importance in regulating emotional behavior has not been explored.
therefore, published studies have specifically studied the importance of STAT3 signal transducting pathways in serotonin energy systems in the mid-brain (emotional regulation center) by targeting STAT3 in mouse models.
Pollak said: "In the case of a systematic selective lack of STAT3 in serotonin in the brain, the mice showed a reduced negative emotional response and a reduced response to anatopycin in the brain.
STAT3 are expressed in both genetic and viral models, it is possible to rule out developmental changes and show that acute manipulation of STAT3 in adult organisms affects emotional behavior.
in animals lacking STAT3, neuron activity in serotonin cells in the brain was also found to have changed.
also found important molecular network changes in neuropsyurological disorders at the level of gene expression.
" our results show that STAT3 plays an important role as a molecular medium in the serotonin energy system that controls emotional responses, thus establishing a mechanism link between the immune system, serotonin delivery, and emotional disorders.
" (Bioon.com) Source: STAT3 identified as important factor in emotional reactivity Contact: Source: Sonali N. Reisinger, Spyros Sideromenos, Orsolya Horvath, Sophia Derdak, Ana Cicvaric, Francisco J. Monje, Martin Bilban, Martin H. Polling, Micaelat, Daniela Pollak. STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology. Molecular Psython, 2020; DOI: 10.1038/s41380-020-00904-2 Original link: