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In-nasal anti-inflammatory treatment is expected to ease the progression of multiple sclerosis.
Time of Update: 2020-10-29
Preclinical studies at the University of Alberta have shown that giving anti-inflammatory drugs in the nose can help ease the progression of multiple sclerosis.
study showed that providing anti-inflammatory drugs to mice through intransific drugation could prevent damage to brain cells and thus effectively alleviate disease progression.
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Ann Neurol: Relationship between blood metal levels and the risk of amyotrophy lateral sclerosis.
Time of Update: 2020-10-29
recently, researchers compared metal levels in blood samples collected from ALS patients and controls to see if metals were associated with ALS mortality, according to a recent study published in Annals of Neurology, an authoritative journal in the field of neurology.
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Neurology: Aspirin safety analysis for patients with stroke and small aneurysm ruptures.
Time of Update: 2020-10-29
A multi-center, forward-looking cohort study aimed at assessing the safety assumption that aspirin is safe for patients with unbromed intracranial aneurysms (UIA) and 7 mm of isovascular disease (ICVD) was published recently in Neurology' authoritative journal Neurology.
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New treatment for alcohol addiction! Fda restarts review of AD04 research new drug applications.
Time of Update: 2020-10-29
relaunching Adial's IND will allow the company to pursue AD04's rapid review in the U.S. and launch Phase I Pharmacodynamics (PK) clinical studies in the U.S.
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JNNP: Cognition and behavior associated with and without amyotrophy lateral sclerosis.
Time of Update: 2020-10-29
prospective comparative study aims to determine whether there are esogic differences in cognition and behavior in patients with FTD-ALS and bvFTD.
: There are differences in cognition and behavior between bvFTD and FTD-ALS and C9ORF72 patients with repeated dilation.
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Crit Care: Elderly weakness, delirium and hospitalization mortality in intensive care units.
Time of Update: 2020-10-29
The study was part of a baseline study of mascology in intensive care, during the first six months of the baseline, the researchers analyzed clinical weakness, acute delirium attacks, intensive care outcomes, and length of hospitalization for adults 50 years of age or older in intensive care.
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Acta Neuropathologica: The cause of stage dependence for re-myelinization of multiple sclerosis.
Time of Update: 2020-10-29
Our results show that there are many reasons for the failure of re-myelinization of multiple sclerosis, which depends on the stage of lesions, including: although there are mature less protrusive glial cells in the subposure of active lesions, but lack of myelin formation; : This study collected samples of paraffin-encumbased brain biopsies and autopsy tissues from 62 patients retrospectively.
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Nat Commun: Identification of epilepsy-related neuron subsypes and genetic analysis of potential expression associated with epilepsy.
Time of Update: 2020-10-29
Epilepsy and non-epileptic temporal cortical analysis of the single-core transcription group found that the largest changes at the transcription group level occurred in several major neuron families (L5-6_Fezf2 and L2-3_Cux2) and GABA intermediate neurons (Sst and Pvalb), while other subshapeds in the same family were less affected.
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At its October meeting, the European Commission on Drugs for HumanIty (CHMP) actively recommended the launch of ten new drugs.
Time of Update: 2020-10-29
It is recommended to approve car-T cell therapy Tecartus from Kite, Kilead, for the treatment of patients with sleeve cell lymphoma.
2. It is recommended to approve Orchard Therapeutics' gene therapy Libmeldy for the treatment of iso-infected cerebral whiteness malnutrition (MLD).
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JNNP: Systematic review and metaanalysis of anti-A beta drug therapy for mild to moderate Alzheimer's disease.
Time of Update: 2020-10-29
study aims to study the efficacy and safety of A-beta-targeted drug therapy for mild and moderate Alzheimer's disease.
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Sci Transl Med: LRRK2 mediates small glial cytotoxicity through NFATc2 synactogenesis.
Time of Update: 2020-10-29
-syn α actoid nucleoproteins released by neurons induce neurotoxic, inflammation-promoting small glial cell reactions through Toll-like subject 2, but their molecular mechanisms are unclear.
study, researchers found that repetitive kinase 2 (LRRK2), rich in leucine, played a key role in activating small glial cells in extracellular α-synth nucleoproteins.
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Acta Neuropathologica: C9orf72 and non-C9orf72 ALS and TLD-TDP cases along the hemline-pituitary axis of dipeptide repetitive protein and TDP-43 pathology.
Time of Update: 2020-10-29
dipeptide repetition protein (DPR) derived from the repeated amplification of C9orf72 in neurons represents another neuropathological feature in patients with C9orf72 ALS and FLD-TDP.
Dipeptide protein repeat and TDP-43 pathology along the hypothalamic-pituitary axis in C9orf72 and non-C9orf72 ALS and FTLD-TDP cases.
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JNNP: Anthoimaging Abnormality and Prognosis after Acute Ishemic Stroke: Intensive Control (ENCHANTED) Trial.
Time of Update: 2020-10-29
The results of the Third International Stroke Trial (IST3) showed that brain imaging signs of acute cerebral ischemia and markers of "brain weakness" could be used individually or in association to predict clinical outcomes and symptomatic intracranial hemorrhage (sICH).
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Lancet Neurology: Galcanezumab's Safety and Effectiveness in Patients Who Failed to Treat 2-4 Migraine Prevention Drugs (CONQUER): A multicenter, randomized, double-blind, placebo-controlled Phase 3b trial.
Time of Update: 2020-10-27
: This study shows that galcanezumab is safe and effective for patients with seizure migraines or chronic migraines who have a history of failure to take preventive medication for migraines.
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PNAS: At 35, it may really be the pinnacle of cognitive ability in our lives.
Time of Update: 2020-10-27
why chess was chosen, the researchers said, "In our empirical model, we rely on data from professional chess because this is typical evidence of human mental activity." same time, we have all the data in our database for the World Chess Championships for nearly 125 years, and if we compare a person's actions with 20 currently powerful computers, we can get a very objective cognitive score.
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Nat Biomed Eng: Facial wearable sensors help patients with amyotrophy lateral sclerosis (ALS) communicate.
Time of Update: 2020-10-27
"You can disguise it, and no one will think there's something on your skin." researchers tested their initial version of the device on two patients with amyotrophic lateral sclerosis (one female and one male, gender balance) and found that it accurately distinguished three different facial expressions - smile, open mouth and mouth.
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JNNP: Mutations in the GCH1 gene and changes in brain structure in patients with doba reactive dystachia.
Time of Update: 2020-10-27
the study, magnetic resonance imaging (1.5t) was used to assess patterns of cortical thickness, substrate volume, and whiteness (WM) microstructage changes in DRD patients and healthy control groups.
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New antipsychotic drugs! ALKS3831 (O nitrogenpin/samidorphan) is about to be approved in the United States: Treatment of schizophrenia/biphalia type I disorder.
Time of Update: 2020-10-24
ENLIGHTEN-1 is a 4-week randomized, double-blind Phase III study conducted in patients with schizophrenia who are experiencing acute exacerbation, comparing the antipsychotic efficacy, safety and tolerance of APKS3831 relative to placebo.
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Science: A rare form of dementia has --- of empty bubble tau protein disease.
Time of Update: 2020-10-24
in addition to studying cellular and animal models, the researchers first looked at the protein itself and found that in this newly discovered disease, the accumulation of tau proteins was actually caused by mutations in VCP.
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New progress has been made in stress regulation of neuron endologic network stress.
Time of Update: 2020-10-23
, however, this acute, intense endotrogenic network stress is rare in neurodegenerative diseases, and endotrogen network stress caused by drug stimulation occurs in a variety of cells and is not neuron-specific.
