Nat Commun: Identification of epilepsy-related neuron subsypes and genetic analysis of potential expression associated with epilepsy.

Epilepsy is a neurological disorder characterized by spontaneous and recurrent seizures, mainly in the hippoc mark or the cerebral cortical region.
epilepsy is still the most common severe chronic brain disease affecting more than 68 million people worldwide.
active epilepsy is a devastating disease that requires ongoing care and a physical, psychological and social burden on patients and families.
one of the most common neurological diseases, little is known about the pathophysiology of epilepsy due to the relative complexity of the affected neuron circuits.
To identify neuron subtypes of seizure-related dysfunction in the human brain, the study aimed to perform a monocical transcriptomic analysis of more than 110,000 neuron transcription groups from temporal cortical samples from patients with multiple temporal lobe epilepsy and non-epilepsy.
Epilepsy and non-epileptic temporal cortical analysis of the single-core transcription group found that the largest changes at the transcription group level occurred in several major neuron families (L5-6_Fezf2 and L2-3_Cux2) and GABA intermediate neurons (Sst and Pvalb), while other subshapeds in the same family were less affected.
a comprehensive analysis of neuron subtypes in patients with epilepsy, the researchers found coordinated changes in the transcription groups of these subtypes, indicating that the subtypes with the greatest changes in the transcriptional group associated with epilepsy may belong to the same circuit.
analysis found that glutamate signaling pathline is one of the most serious disorders in epilepsy, which is manifested in layer-by-layer transcriptional changes of multiple glutamate subject genes and significant increases in gene expression levels encoded by AMPA subject-assisted sub-base.
, the results reveal molecular esoteric molecular esotypes of neuron-specificity associated with epilepsy.
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