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Scientific Reports : The human brain is born to see words.
Time of Update: 2020-10-30
A new study shows that a region of the human brain is born with the ability to receive words and letters, laying the foundation for learning to read at birth. analyzing brain scans of newborns, the r
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Neurology: Dementia risk in patients with late-onset epilepsy.
Time of Update: 2020-10-30
Based on neuropsychological tests, interviews, and discharge monitoring, the researchers assessed the association between LOE and dementia by 2017 using cox proportional risk regression models; 9,033 ARIC participants had sufficient health insurance coverage data (4,980 women and 1993 blacks), 671 of whom met the LOE definition.
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JNNP: Trauma and depressive symptoms in middle-age people with high-risk dementia: Preventive dementia research.
Time of Update: 2020-10-30
Changes in brain structure and function suggest that depression in patients with AD is associated with disruption of the symposia of the forehead and the lower cortical edge pathline, and this study examined the association between childhood trauma, depression, adult cognitive function and dementia risk.
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Ann Neurol: Retinal thickness predicts the risk of cognitive decline in Parkinson's disease.
Time of Update: 2020-10-30
researchers used a linear hybrid model to estimate the thickness reduction rate of the plex complex (GCIPL) and retinal nerve fiber layer (pRNFL) around the nipple, and used clinically significant thresholds to calculate the risk ratio to assess the association between baseline GCIPL and pRNFL thickness and subsequent cognitive and motor deterioration risk.
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Academician Wu Yiling: There are 330 million cardiovascular patients in China, and the common pathogenesis is microvascular lesions.
Time of Update: 2020-10-30
The vasculation theory constructed by Wu Yiling academician system to guide the prevention and treatment of microvascular lesions is a major theoretical original achievement, while the communication Chinese medicine heart capsule developed under the guidance of the vein theory has been confirmed by a large number of basic research and clinical evidence-based medical research, with the function of protecting microvascular vessels.
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Curr Biol: Sleep less and don't get sleepy, an enviable genetic mutation that causes natural short sleep.
Time of Update: 2020-10-30
all, the study showed that GRM1 is another short sleep gene, and that people and mice with the mutation will show shorter sleep times.
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Science: Discovery of a rare dementia gene opens up new avenues for treating diseases such as Alzheimer's disease.
Time of Update: 2020-10-30
In the study, researchers examined brain tissue samples from deceased donors with unknown neurodegenerative diseases and found a new mutation in the gene containing casein (VCP) in the brain, in which the patient's degenerative brain region produces pathological tau protein and forms a neuron hole, also known as a vacuole.
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Acta Neuropathologica: The accumulation of end fragments of amyloid preloom protein C triggers mitochondrial structure, function, and filamentation defects in Alzheimer's models and the human brain.
Time of Update: 2020-10-30
collecting the liquid as the total fraction, the other part at 4 degrees C at 10000 × g centrifugation for 10 minutes to precipitate mitochondrial fractions, it suspended in a separation buffer with protease inhibitors added.
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Neurology: Is it really good not to eat fireworks? People who are not interested in what's around them are more likely to develop Alzheimer's disease.
Time of Update: 2020-10-30
Overall, the recently published study found in a group of adults in the community that people who were not interested in what was around them were at greater risk of developing Alzheimer's disease.
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Acta Neuropathologica: MOG expression teratoma secondary MOG-IgG positive optic neuritis.
Time of Update: 2020-10-30
Sub-tumor ethonology was reported in a small number of patients with water channel protein-4 (AQP4)-IgG serotonin-positive optic neurospinalitis spectrum disorder (NMOSD), with lung and breast cancer being the most common associated malignancies.
MOG expressing teratoma by MOG-IgG-positive optic neuritis.
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Nature BME: Identify mental disorder subsypes from the electro-encephalogram functional connection pattern in a resting state.
Time of Update: 2020-10-30
Psychiatric diagnoses are defined based on the clinical manifestations of symptoms designed to describe healthy individuals and other specific conditions for diagnosis.
Although the four subtypes in the study focused on no difference in baseline clinical severity, their clinical outcomes were indeed different in psychotherapy (for PTSD) or antidepressant and placebo (MDD) treatment.
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Mol Neurobiol:Drinking makes people silly, and studies have shown that drinking alcohol accelerates the onset of Alzheimer's disease and makes its symptoms worse.
Time of Update: 2020-10-30
The potential mechanisms of alcohol-induced small glial cell eCIRP to promote the development of Alzheimer's disease have long been shown that long-term alcohol exposure can lead to abnormal phosphate of the neural tau protein in the hema body and induce the occurrence of Alzheimer's disease, and now this study sheds light on the key molecular mechanisms of this process, and the future targeting of eCIRP may become a new treatment strategy for preventing and mitigating alcohol-induced Alzheimer's disease.
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Autophagy: Cannabinin causes motor dysfunction by suppressing autophagy.
Time of Update: 2020-10-30
combination of various genetic strategies in the body also supports the idea that CNR1 molecules located on neurons belonging to the direct (syroid) pathway are necessary for the autophagy and motor damage activity of THC.
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Neurology: A two-way association between epilepsy and dementia.
Time of Update: 2020-10-30
In this case group, participants with any high school education had a nearly five-fold increased risk of developing dementia (HR=4.67 (1.82-12.01) and p=0.001) compared to those with the same level of education.
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Science Advances : Significant progress! Xue Xue/Shi Bingyang/Zheng Meng developed a new delivery method to deliver siRNA to the brain to treat Alzheimer's disease.
Time of Update: 2020-10-30
Compared to small molecule-based methods, small interfering RNA (siRNA) provides promising therapies for the treatment of brain diseases by directly blocking pathogenic gene expression with high target specificity, low effective dose and relatively simple drug development processes.
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JNNP: Clinical efficacy of different doses of the athroposis interval drug treatment in patients with multiple sclerosis in Italy.
Time of Update: 2020-10-29
to assess the effectiveness, materials and methods of NTZ in people with multiple sclerosis in Italy: This retrospective multi-center study included patients with relapsed relapsed remission-relieved multiple sclerosis (RR-MS) treated with NTZ between June 1, 2012 and May 15, 2018, followed by an "Italian MS registration." all MS patients were divided into two groups according to the NTZ dosing schedule: standard interval dosing (SID) patients (average 28-32 days) and extended interval dosing (EID), including 33-49 days (median 43).
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JNNP: Comparison of Deep Brain Stimulation and Magnetic Resonance Guidance Focused Ultrasound therapy for Idiotic Tremors: Systematic Review and Comprehensive Analysis of Functional Results.
Time of Update: 2020-10-29
method: The authors systematically reviewed the preferred reporting items based on systematic review and meta-analysis to compare the tremor severity and quality of life of one-sided MRFUS pasytherapy with one-sided and two-sided DBS therapy ET.
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FINTEPLA (Finfluoramine) treats seizures of Dravet syndrome: CHMP has a positive review.
Time of Update: 2020-10-29
biopharmaceutical company Zogenix recently announced that the European Medicines Agency (EMA) Human Medicines Commission (CHMP) has recommended that FINTEPLA® marketing licenses be granted to treat seizures associated with Drafet syndrome.
Phase III studies of fenfluoramine have shown that fenfluoramine reduces the frequency of seizures in patients with Dravet syndrome." .
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JAHA: Relationship between the N end of the brain and atrial sodium peptide preaphed and the dynamic brain auto-regulation.
Time of Update: 2020-10-29
Dynamic Brain Auto-Regulation (dCA) was determined in the 30th year of the assessment by a cranial Doppler ultrasound, and the researchers used a transfer function analysis (phase and gain) of spontaneous blood pressure and flow rate oscillations, where lower phases and higher gain reflected lower brain auto-regulation efficiency.
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J Am Soc Nephrol: The American Society of Nephrology says less than six hours of sleep hurts the kidneys, and healthy kidneys require good sleep.
Time of Update: 2020-10-29
showed that both short sleep and long sleep duration were associated with a higher incidence of chronic kidney disease.
