JNNP: Anthoimaging Abnormality and Prognosis after Acute Ishemic Stroke: Intensive Control (ENCHANTED) Trial.

The results of the Third International Stroke Trial (IST3) showed that brain imaging signs of acute cerebral ischemia and markers of "brain weakness" could be used individually or in association to predict clinical outcomes and symptomatic intracranial hemorrhage (sICH).
low tissue density, excessive arterial density, and previous infarction increase the risk of sICH.
Internationally, enhanced control studies of hypertension and thrombosis stroke (ENCHANTED) include a wider range of patients with the opportunity to determine whether the dose of aptide affects the results, and whether a less experienced brain imaging analysis team that is more representative of everyday clinical levels will produce similar results.
The purpose of this paper is to verify the clinical results and hypothesis of symptomatic intracranial haemorrhage (sICH) after acute ischemic stroke (AIS) thrombosis in the arm of the ENCHANTED ateptase dose.
Method: The blind evaluator encodes images of acute isothermic symptoms (presence, degree, swelling and attenuation of acute lesions; excessive arterial hyperemia) and pre-existing changes (atrophy, white matter looseness, and obsolete isotrophic lesions).
Logistic regression model assessed the relationship between imaging characteristics and 7- and 90-day deaths: well-judged recovery (improved Rankin score 0-2 on 90 days) and sICH.
use adjusted OR and 95% CI to record data.
results: 2916 patients (67±13 years old, in line with the National Institutes of Health stroke scale) were selected.
visible isoemia injuries, severe low density, extensive isothermic injuries, swelling and over-focused arteries associated with 7 days of death (OR (95%CI): 1.52 (1.06-2.18); -2.18); 2.67 (1.52-4.71); 1.49 (1.03-2.14) and 2.17 (1.48-3.18).
is the opposite of good results.
severe contraction was negatively associated with 7-day deaths (0.52 (0.29 to 0.96).)
(1.52 (1.08-2.15)) and severe white matter deficiency (1.74 (1.20-2.54)) were associated with 90 days of death.
arterial overfusion was associated with sICH (1.71 (1.01 to 2.89)).
no imaging characteristics to alter the effects of the dose of atipase.
non-expertly defined brain imaging signs of cerebral weakness and acute ischemia were associated with prognosis and mortality in the treatment of AIS patients with thrombosis.
, however, these imaging features do not interact with the dose of atipase.
Delcourt C, Wang X, Zhou Z, et al Brainimaging abnormalities and outcomes acute after ischaemic: stroke the ENCHANTED trialJournal of Neurology, Neurosurgery and Psychic Publishing Online First: 14 October 2020. doi: 10.1136/jnnp-2020-323015MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Met Medical" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual. Source: Mays Medicine.
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