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JNNP: Pale ball deep encephaloelectritis treatment of primary Meige syndrome: clinical results and mental characteristics.
Time of Update: 2020-10-21
the effectiveness and safety of the treatment of resusctic Meige syndrome (MS) with deep cerebral electrical stimulation (GPi-DBS) in pale balls on both sides, and evaluate preoperative and postoperative mental disorders.
: Retrospective analysis of 22 patients with MS treated with two-sided GPi-DBS continued preoperative and postoperative nerve stimulation.
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Acta Neuropathologica: Exogenomics, Genomics, and Transcriptomic Histology of Neuroblastoma.
Time of Update: 2020-10-21
summary, we note that there is a considerable correlation between specific molecular changes in SWNTS-SWNs and system mutations in LZTR1, including high prevalence of NF2 cell mutations and absences, higher CNV, prevalence of pain, and fusion of SH3PSD2A-HTRA1.
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The p38 alpha inhibitor Neflamapimod was clinically successful in the treatment of Stage II of Louisian dementia, and patients' cognition improved significantly.
Time of Update: 2020-10-21
At the 13th Clinical Trials (CTAD) of Alzheimer's Disease, EIP Pharmaceuticals announced that the central nervous system disease drug Neflamapimod (VX745) is treating patients with mild to moderate Louisian dementia (DLB), with Phase II trials reaching the primary endpoint.
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Acta Neuropathologica: In organ-type brain tablet culture and in the body, neuron activity regulates the α and diffusion of ana-synth nucleoproteins.
Time of Update: 2020-10-21
drug-enhanced neuron activity significantly increased alphaSyn pathological changes and accelerated the degeneration of dopamine-energy neurons in the development of sea horses or mid-brain slices treated by alphaSyn PFF.
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After the epidemic, we need to pay more attention to mental and psychological problems, and restoring social function is the ultimate goal of depression treatment.
Time of Update: 2020-10-21
After the outbreak of mental and psychological problems more need to pay attention to The introduction of Lu Lin, China's National Center for Clinical Medicine of Mental Illness, an online survey covering more than 50,000 residents showed that during the outbreak, the average population depression, anxiety, insomnia and acute stress symptoms of the rate of about 30%, including front-line staff, chronically ill patients and other special groups of the psychological health status is even more worrying.
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Sci Adv: Domestic universities have made a major breakthrough in the field of Alzheimer's disease! It is expected to help patients regain their cognition.
Time of Update: 2020-10-21
report says researchers have found an effective method of siRNA brain delivery and developed a sugar-based "triple interaction" of the stable polymerized siRNA nanopedit, Gal-NP@ siRNA, which has been shown in mouse experiments to penetrate the blood-brain barrier effectively, restoring cognitive ability in AD mice without significant side effects.
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Stroke: High blood sugar is associated with adverse outcomes after in-vascular treatment in patients with ischemic stroke.
Time of Update: 2020-10-21
researchers assessed the association between hospitalization blood sugar and a 90-day improved Rankin scale score, symptomatic intracranial bleeding, and successful refill rates.
Compared to patients with non-hyperglycemia, high blood sugar and functional deterioration in hospital (improved Rankin scale score 4 vs.
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Acta Neuropathologica: TDP 43 transports the nuclear glycoprotein mRNA to regulate the partial translation of the axons of neuron axons.
Time of Update: 2020-10-17
Our results illustrate the new function of TDP-43 in controlling RP-mRNAs transport and local translation of rnucose bodies to maintain the morphological integrity of neuron axons, and demonstrate the effect of this function of TDP-43 on neurodegenerative variants of ALS and FLD associated with TDP-43 protein disease.
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Stroke: Relationship between gastrointestinal disease and the risk of first ischemic stroke.
Time of Update: 2020-10-17
researchers used the Cox proportional risk model to assess the correlation between the category of gastrointestinal diseases and ischemic stroke, and to adjust demographic and known vascular risk factors.
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A pat on the neck that's paralysed? This kind of "Japanese disease", do not press at will!
Time of Update: 2020-10-17
" on-duty doctor introduced, due to the emergency situation, the next day Wang Yue team to lao Mao carried out C5, C6 vertebral surgery, surgery can be seen, the spinal cord of his cervical spine was bone-crushed after the ligament compression, local pressure is obvious.
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Stroke: The relationship between hospitalization of blood pressure and clinical outcomes and successful refilling after in-vascular treatment in stroke patients.
Time of Update: 2020-10-17
, it can be seen that in patients with acute ischemic stroke treated with EVT, higher hospitalization BP was associated with a lower likelihood of successful refilling and poor clinical outcomes.
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What about frequent headaches? Check your eyes!
Time of Update: 2020-10-17
In recent years, studies have found that the opening of the heart's egg round hole is one of the causes of migraines, and some patients can be treated with surgery to relieve long-term headaches.
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Acta Neuropathologica: Direct nerve transfer of vCJD/BSE after the monkey finger is cut open.
Time of Update: 2020-10-17
, we have observed that primates exposed to vCJD/BSE through distant finger damage, after 7.5 years of silent incubation, can lead to large amounts of PrPd deposition, severely restricted to the nervous system and eyes.
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JNNP: Deep brain stimulation of the hypothyroids of patients with obsessive compulsive disorder: an open, forward-looking, long-term follow-up of observational queues.
Time of Update: 2020-10-17
method: The effects of chronic non-motor stN-DBS treatment in 19 patients with resoccurring obsessive compulsive disorder (OCD) were analyzed by using forward-looking, observational, single-center, open cohort study method.
: Non-motor STN chronic DBS is an effective and relatively safe method for treating severe obsessive compulsive disorder, which is resistant to conventional treatment.
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The FDA Advisory Committee voted in favour of APKS 3831 for the treatment of schizophrenia and biplex disorder.
Time of Update: 2020-10-17
pharmaceutical company Alkermes announced today that the U.S. Food and Drug Administration's (FDA) Advisory Committee on Psychopharmaceuticals and the Advisory Committee on Drug Safety and Risk Management voted in favour of APKS 3831 (Otoxepine/Shamedofen) for the treatment of schizophrenia and biphasia.
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One patient died in a Phase II/III study of gene therapy type IIIA adhesive polysaccharose storing disorder.
Time of Update: 2020-10-17
Lysogene disclosed Thursday that one patient in the Phase II/III AAVance study died and is undergoing gene therapy LYS-SAF302 to treat type IIIA adhesive polysaccharose storage disorder (MPS IIIA).
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Acta Neuropathologica: Insulin-like growth factor 2 (IGF2) prevents Huntington's disease by treating protein aggregates outside the cell.
Time of Update: 2020-10-17
the team of authors has previously reported on the target transcription factor XBP1, a key medium for endoensurgen stress response, which slows disease progression and reduces protein aggregation in various neurodegenerative variant models.
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Acta Neuropathologica: MAP kinase p38 reduces tau-mediated late memory defects.
Time of Update: 2020-10-17
above, our results show that tau phosphatization, which is specific to the target bits by synaptic post-kinase p38, is a potential treatment that can reduce memory impairment in existing A-beta-induced AD mouse models.
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Reduce the sense of shame, good mood joint media release public welfare short film "Acceptance"
Time of Update: 2020-10-17
October 10, 2020 is the 29th World Mental Health Day, good mood in the People's Daily Health Client, Health Times, Arterial Network and other media, issued a public welfare short film "Acceptance", jointly called for the rejection of stigma and reduce the sense of shame.
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Acta Neuropathologica: Blue spot degeneration is a common feature of tau disease, unlike TDP-43 protein lesions in the frontal temporal lobe degeneration spectrum.
Time of Update: 2020-10-17
, we have validated the hypothesis that FTLD-TAU's LC neuropathology and neurodegenerative changes are significant compared to FLD-TDP.
the pathological and clinical subgroups of FTLD-TDP, the tau load and neurodegenerative changes of LC continued to increase compared to the FLD-TDP subgroup.