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Neurology: A binational cohort study from Denmark and Sweden: the pain of bereavement increases the risk of parental stroke, and more social support and attention are needed!
Time of Update: 2022-03-02
Growing evidence of child deaths in children suggests that parents who experience child deaths have higher morbidity and mortality rates, including myocardial infarction , coronary artery disease, ventricular fibrillation, heart failure, and cardiac sudden death .
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Depression linked to heart disease and type 2 diabetes, study of nearly 330,000 people finds
Time of Update: 2022-03-02
A study published on February 14 in nature cardiovascular research showed that lower frequency of depression was associated with a 34% lower risk of coronary artery disease, a 33% lower risk of type 2 diabetes , and a 20% lower risk of atrial fibrillation .
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Neurology: Combining neuroanatomical and functional neuroimaging, cerebellar transcranial magnetic stimulation, cerebellar dysfunction in patients with PRRT2-related paroxysmal dyskinesia
Time of Update: 2022-03-02
It is hypothesized that in patients with PRRT2 pathogenic variants, abnormal cerebellar output is the major dysfunction, resulting in dysregulation of the striatum and paroxysmal dyskinesia .
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Trust your "gut": "Fake sugar" can fool the taste buds, but not the "gut"...
Time of Update: 2022-02-23
Then, using optogenetics, the researchers could control neuropod cells in the mouse gut to turn "on" and "off" to test whether the animals' preference for real sugars was driven by gut signals .
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Alzheimer's at 27?
Time of Update: 2022-02-23
, and insufficient evidence for endocrine-related diseases; vitamin B12 223pg/ ml (normal range: 211-946pg/ml), folic acid 1.
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Science Advances Zhejiang University of Traditional Chinese Medicine Wang Yi/Chen Zhong develops new nano-drug delivery system, on-demand drug delivery system is expected to improve the effect of epilepsy treatment
Time of Update: 2022-02-23
On January 12, 2022, a research paper titled "Nanoengineered on-demand drug delivery system improves efficacy of pharmacotherapy for epilepsy" was published online in Science Advances by Wang Yi and Chen Zhong from Zhejiang University of Traditional Chinese Medicine.
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[Nature Sub-issue] Why can't I stop eating sweets?
Time of Update: 2022-02-23
Recently, a team of researchers led by Diego Bohórquez, associate professor of medicine and neurobiology at Duke University School of Medicine, found the answer to the puzzle: The cells that distinguish natural sugars from artificial sweeteners reside between the stomach and gut .
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A number of well-known experts jointly wrote a long review of "Neural Circuit Regulation of Instinct Behavior"
Time of Update: 2022-02-23
Figure 5 Subcortical and cortical circuits that control urination Finally, the article summarizes that technological development has played an important role in promoting neural circuit research, and points out that cortical areas play an unacceptable role in the regulation of instinctive behavior by integrating external sensory stimuli.
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Sci Adv Lin Guanning/Wang Zhen team first proposed that the pathogenesis of obsessive-compulsive disorder may be related to chromatin structural disorders
Time of Update: 2022-02-23
Recently, the team of Professor Lin Guanning from the School of Biomedical Engineering of Shanghai Jiao Tong University and the team of Chief Physician Wang Zhen of the Mental Health Center Affiliated to Shanghai Jiao Tong University School of Medicine conducted a genome-wide analysis of the core family (patients with obsessive-compulsive disorder and their healthy parents) cohort for obsessive-compulsive disorder.
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Major events in the field of Parkinson's disease in 2021, an inventory
Time of Update: 2022-02-23
Studies suggest that reduced lysoKGF function will accelerate the accumulation of pathological α-synuclein, resulting in accelerated cognitive and motor decline in Parkinson's disease patients .
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Lancet Neurol Annual Review: Epilepsy in Neurology Summary 2021
Time of Update: 2022-02-23
Subdural electrode assessment is more beneficial than SEEG for brain surgery in patients with drug-resistant epilepsy, but has more surgical complications and is less likely to be seizure-free .
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Lancet Neurol Annual Review: 2021 Neurology Summary of Multiple Sclerosis
Time of Update: 2022-02-22
Among 1626 patients with multiple sclerosis and SARS-CoV-2 infection reported between April and December 2020 in the North American registry, male gender, older age, cardiovascular disease, and obesity were associated with severe COVID-19 and death .
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Hu Xiquan/Pan Guangjin's team revealed the effect of exercise-promoted stem cell transplantation in the treatment of stroke
Time of Update: 2022-02-22
Studies have found that timely exercise training after surgery can significantly promote the differentiation and maturation of transplanted human neural stem cells, and form neural circuits with host neurons, shortening the process to 1-3 months .
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Sci Adv｜Chen Zhong's team treats epilepsy with an electrically responsive co-targeted nano-drug delivery system
Time of Update: 2022-02-22
This study uses multidisciplinary technology to design an electric field-sensitive nano-drug delivery system with combined brain targeting capability for the precise delivery of anti-epileptic drugs, aiming at the disease characteristics of abnormal brain discharge during epilepsy.
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【Literature Interpretation】: A recent meta-analysis: changes in motor function in patients with type 2 and type 3 SMA after treatment with nosinasan
Time of Update: 2022-02-22
Figure 1 The data in the above papers were analyzed using the PRISMA framework search and selection process to observe the changes and standard deviations of individual motor prognostic indicators in different treatment groups, and grouped by age (children, adults), motor function (walking, unable to walk) And SMA classification (type 2, type 3) for subdivision .
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Quiz: The symptoms and signs of Parkinson's disease, have you mastered all these questions?
Time of Update: 2022-02-22
Question 1 In the process of early clinical diagnosis of Parkinson's disease, which one is the classic symptom?
Smell tests may reveal hyposmia, which precedes motor symptoms by years, providing evidence for the onset of Parkinson's disease .
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CNS top issue!
Time of Update: 2022-02-22
Faced with such a "precise" organ, how to efficiently conduct multi-faceted research on it has always been a headache for many scientists: 1) Popular methods such as immunostaining or flow cytometry (FACS) 2) key stem cell and neural progenitor cell populations are difficult to isolate without prior knowledge of specific molecular markers; 3) early single-cell RNA-sequencing techniques (scRNA-seq) is extremely limited by low cell numbers .
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The diagnosis and treatment of Parkinson's disease, these knowledge points must be mastered
Time of Update: 2022-02-22
Knowing these symptoms aids in early diagnosis and, by recognizing the impact of non-motor performance on disability and quality of life, can aid in effective treatment .
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Lancet Neurol Annual Review: 2021 Neurology Summary Headache
Time of Update: 2022-02-22
Further advances in genetics are provided by a large cohort study including 860 patients with hemiplegic migraine, which elucidated the genotype-phenotype link between PRRT2 autosomal dominant mutations and hemiplegic migraine .
Among 163 patients with hemiplegic migraine, PRRT2 mutations were present in 12 (7.
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"The Lancet" Journal of China's 10,000 People Study: Pay Attention to Muscle Loss in Middle-aged and Older People!
Time of Update: 2022-02-22
Long-term follow-up of nearly 15,000 Chinese middle-aged and elderly people showed that sarcopenia is associated with a significantly higher risk of cardiovascular disease, including cardiac Disease and stroke .
