Hu Xiquan/Pan Guangjin's team revealed the effect of exercise-promoted stem cell transplantation in the treatment of stroke

With the advancement of medicine, the survival rate of stroke patients has been improved, but more than 80% of the survivors have neurological dysfunction, such as common motor and sensory dysfunction, for which there is currently no effective treatment
.

Cell replacement therapy represented by neural stem cells is expected to bring hope for the cure of related diseases
.

However, whether the transplanted neural stem cells can integrate with the host nervous system and have in vivo functions is still questionable, hindering the clinical translational application of neural stem cell therapy
.

Recently, Pan Guangjin's team from Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences cooperated with the team of Professor Hu Xiquan of the Third Affiliated Hospital of Sun Yat-sen University, and published a paper entitled: Physical exercise promotes integration of grafted cells and function recovery in an journal Stem Cell Reports Research paper on the acute stroke rat model
.

In this study, ischemic stroke (MCAO) animals were used as models to carry out in-depth research on neural stem cell therapy, and new progress was made in neural stem cell transplantation combined with exercise training to promote the in vivo maturation of transplanted neural cells and the restoration of animal behavioral functions
.

It takes a long time for human nerve cells to mature in vivo.
Most studies show that it takes half a year to more than one year, and it is easy to miss the best time window for rehabilitation after stroke
.

Studies have found that timely exercise training after surgery can significantly promote the differentiation and maturation of transplanted human neural stem cells, and form neural circuits with host neurons, shortening the process to 1-3 months
.

The experimental group of cell transplantation combined with exercise training was significantly better than the injured control group, single cell transplantation and single exercise training group in terms of cerebral infarction volume, neuron differentiation and maturation, and host neurovascular regeneration, and also showed the best performance in motor function recovery.
good
.

Further mechanistic studies showed that the combined interventional approach created an intracerebral microenvironment favorable for neuronal survival and regeneration: significantly increased levels of neurotrophic factors, enhanced angiogenesis, and significantly decreased levels of inflammation and oxidative stress at the lesion site; synaptic ( The connection between neurons) and neural plasticity are activity-dependent, and exercise training causes a significant increase in the activity level of related nerve synapses and neurotransmitter levels, thereby promoting the reconstruction of damaged neural circuits and the recovery of motor function
.

Mouse experiments have shown that rehabilitation training promotes the maturation of transplanted nerve cells and circuit reconstruction.
Because of its non-invasive, safe, low-risk and no side effects, exercise training has been widely used in the recovery of brain injury
.

This study shows that exercise training can promote the maturation and integration of transplanted cells.
The combined intervention of neural stem cell transplantation and exercise training is expected to provide a new treatment plan for related neurological diseases, which is of positive significance for promoting the clinical transformation of neural stem cells
.

Paper link: https://doi.
org/10.
1016/j.
stemcr.
2021.
12.
006 Open for reprinting, welcome to forward to Moments and WeChat groups