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By designing specific primer pairs for bacterial 16S rDNA, the pollution-free sequencing analysis and quantitative detection of plant endophytes are realized
Time of Update: 2021-10-02
Recently, Zhang Lili and Fang Rongxiang’s team from the Institute of Microbiology of the Chinese Academy of Sciences and the Wu Jianxiang research team of Zhejiang University jointly published a research paper entitled "Designing specific bacterial 16S primers to sequence and quantitate plant endo-bacteriome" in Science China Life Sciences.
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Science China Life Sciences publishes a review of new coronavirus protein research
Time of Update: 2021-10-02
Academician Gao Fu from the Institute of Microbiology, Chinese Academy of Sciences published an online review article entitled "Overview of SARS-CoV-2 genome-encoded proteins" in Science China Life Sciences (English version of "Science China: Life Sciences"), systematically expounding the current The SARS-CoV-2 encoded protein was analyzed, and the structure, biological function and potential drug design targets of each protein were discussed in depth .
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Zhao Fangqing's team reveals the evolutionary laws and determinants of the intestinal flora in the early stages of life
Time of Update: 2021-10-02
Low, corresponding to the early stage of neonatal development; while infants dominated by Bacteroides and Prevotella have more complex metabolic pathways related to the intestinal flora, with higher species diversity and higher maturity.
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"Fragile Genes": Redefining the Key Genes in Mycobacterium Tuberculosis
Time of Update: 2021-10-02
In response to the above problems, Professor Rock and others from Rockefeller University recently scanned the gene loci in Mycobacterium tuberculosis through CRISPRi technology and defined a new method for measuring the importance of bacterial genes: the vulnerability of genes, that is, if Achieving incomplete inhibition of this gene can still cause a significant decrease in the vitality (fitness, growth rate and competitiveness) of the bacteria .
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Yu Xuekui's team from Shanghai Institute of Medicine explained the molecular mechanism of "pressure sensing and regulation" in the process of herpes virus genome packaging, stabilization and release
Time of Update: 2021-10-02
This study uses cryo-electron microscopy to analyze the in situ structure of the first beta subfamily herpes virus—HCMV's high-resolution portal and capsid vertex-specific components (CVSC), in order to understand herpes virus genome packaging, The molecular mechanism of "pressure sensing and regulation" in the process of stabilization and release provides new ideas .
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Researchers propose a de novo synthetic virus RdRP triggers RNA synthesis and induces a fit mechanism
Time of Update: 2021-10-02
When the substrate is bound, the initiation can be achieved by allosteric in the “induced fit” method, and then this mechanism may be generalized by investigating the structure and sequence characteristics of the initiating element of representative de novo RdRP (Figure 3) .
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Joint report by Chinese scientists: New coronavirus RNA does not have the ability to integrate into the host genome
Time of Update: 2021-10-02
1007/s13238-021-00861-8 First, the research team performed RNA sequence analysis on 293T, Huh-7, and Calu-3 cells infected with the new coronavirus, from 293T, Huh- 347, 3107 and 4171 chimeric genes were identified in 7 and Calu-3 cells .
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Chen Yihua's research group from the Institute of Microbiology, Chinese Academy of Sciences discovered a novel initiation mechanism for polyketides
Time of Update: 2021-10-02
Chen Yihua’s research group at the Institute of Microbiology, Chinese Academy of Sciences has been committed to the biosynthesis and synthetic biology of microbial natural products.
In the work just published (Nat Commun, 2021, 12:4499), the research team discovered a novel and widespread online modification initiation mechanism for methyl esterification of polyketides .
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AEM cover article: Professor Xu Zhenghong’s team reported the evolution mode and driving factors of the pit mud flora under the influence of long-term wine production
Time of Update: 2021-10-02
org/toc/aem/87/17) Research results "Mining the Factors Driving the Evolution of the Pit Mud Microbiome under the Impact of Long-Term Production of Strong-Flavor Baijiu" It was officially published in Applied and Environmental Microbiology (IF=4.
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New crown-associated coronavirus found in British bats for the first time
Time of Update: 2021-10-02
On July 19, 2021, researchers from the University of East Anglia in the United Kingdom, the Zoological Society of London and the Public Health Agency of the United Kingdom published a research paper entitled: Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe in Scientific Reports .
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Can the new crown infect mice?
Time of Update: 2021-10-02
Most importantly, some studies by them and other teams have also proved that the N501Y mutation significantly enhances the binding affinity of the new coronavirus RBD and mouse ACE2, resulting in acquired infection and pathogenic phenotype in mice .
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Cell Host & Microbe Zhang Jinwei team collaborated to discover the structural mechanism of host tRNA regulating HIV Gag membrane positioning
Time of Update: 2021-10-02
In 2014, the Paul Bieniasz research group of the Rockefeller University found that the matrix protein in HIV-infected cells was mainly cross-linked with the host's tRNA through ChIP-Seq analysis [2] .
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Sci Adv Yan Feng's research team develops a new type of virus detection sensor
Time of Update: 2021-10-01
In addition to serum-based detection methods, SARS-CoV-2 IgG can also be detected in saliva.
By reducing the concentration of the electrolyte (PBS solution) used in the detection and increasing the Debye shield length, the detection limit of SARS-CoV-2 IgG can be reduced from 10 pM to 100 fM .
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Pharaoh scientists discovered in Laos the coronavirus that is closest to the new coronavirus so far, and it also has the potential to infect human cells
Time of Update: 2021-10-01
These viruses have the same potential to infect human cells as the original strains of the new coronavirus .
This study emphasizes The bat coronavirus that may infect humans has always existed in nature and may appear at any time .
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Virus discoveries other than the new crown are rewriting the long article in Biology "Nature"
Time of Update: 2021-10-01
By 2016, scientists still need to cultivate viruses and their hosts before they can submit a new virus species and taxonomy to ICTV, with few exceptions .
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The success of weight loss is closely related to your intestinal flora!
Time of Update: 2021-10-01
Recent human experiments have also shown that the baseline composition of the intestinal flora can determine the individual’s response to weight loss interventions .
In this study, the researchers also found that in individuals who succeeded in losing weight, the baseline bacterial growth rate was higher, partly driven by Prevotella .
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Sciencepar-seqFISH-spatial transcriptome analysis technology of microbial populations at single cell resolution
Time of Update: 2021-10-01
The research team developed a Qualcomm Parallel sequential fluorescence in situ hybridization par-seqFISH (parallel sequential fluorescence in situ hybridization) technology, the use of this technology can obtain a single bacterial gene expression profile while retaining the spatial environment information, and can analyze different bacterial subgroups The mechanism of metabolic changes .
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JHM column East China Normal University Xie Bing team: Macrotranscriptome analysis reveals the mechanism of antibiotics affecting the co-digestion of kitchen waste and sludge to produce methane
Time of Update: 2021-09-30
127163 Picture Abstract Introduction Recently, East China Normal University Xie Bing The team of professors published a research paper titled "Metatranscriptomic insight into the effects of antibiotic exposure on performance during anaerobic co-digestion of food waste and sludge" in the Journal of Hazardous Materials, a well-known journal in the environmental field.
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The gut is an immune system training camp, which determines whether it is a superhero or a rogue villain.
Time of Update: 2021-09-28
Immune cells: The superhero of the body When we eat and drink, the substances entering the intestine may bring potential enemies, such as pathogenic bacteria and viruses .
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How to keep the gut youthful for sedentary people
Time of Update: 2021-09-28
Probiotics and foods that are conducive to the growth of probiotics can be supplemented in an appropriate amount to fundamentally maintain the intestinal tract .
Probiotics and foods that are conducive to the growth of probiotics can be supplemented in an appropriate amount to fundamentally maintain the intestinal tract .
