Pharaoh scientists discovered in Laos the coronavirus that is closest to the new coronavirus so far, and it also has the potential to infect human cells

In a new study published on the preprint server "Research Square" on September 18, Beijing time, a research team from the Pasteur Institute in France and the University of Laos found bats carried and carried in a cave in a limestone karst in northern Laos.
SARS-CoV-2 (new coronavirus) is a coronavirus with common characteristics
.

These viruses have the same potential to infect human cells as the original strains of the new coronavirus
.

This brings scientists closer to determining the origin of the new coronavirus
.

Currently, Nature Portfolio magazine is considering publishing this paper
.

It is known that viruses closely related to SARS-CoV-2 exist in nature, including several horseshoe bats (Rhinolophus) populations
.

This research once again provides strong evidence for the idea that the coronavirus carried by bats began to spread to humans after a spillover effect
.

Last week, a new study published on the preprint server medRxiv found that in areas where horseshoe bats are concentrated in Southeast Asia, about 1,000 similar infections may occur every day, but these incidents have never developed to a detectable level, so No large-scale outbreak has occurred
.

In this new study, the researchers analyzed 247 blood samples and 608 saliva collected from 645 bats of 46 species in 6 families captured at four locations in Vientiane Province, Laos between July 2020 and January 2021.
Samples, 539 anal swabs/feces and 157 urine swabs
.

These bats live in caves of limestone karst (karst) landforms commonly seen in Laos, Vietnam and other countries in the Indochina Peninsula
.

Researchers discovered three new bat coronaviruses, which were named BANAL-52, BANAL-103 and BANAL-236
.

Among them, the receptor binding domain (RBD) of BANAL-236 is only one or two residues apart from the RBD of the original SARS-CoV-2 (new coronavirus) strain, and its binding efficiency to the human ACE2 protein is isolated from earlier human cases.
The SARS-CoV-2 strain is equally effective and mediates ACE2-dependent entry into human cells.
Moreover, it can also be inhibited by antibodies that neutralize SARS-CoV-2
.

Marc Eloit, the co-corresponding author of the study and the head of pathogen discovery at the Pasteur Institute, said: "The newly discovered viruses are the coronaviruses that are the closest to the ancestors of the new coronavirus
.

They may essentially constitute the future direct transmission of coronaviruses to humans.
Risk
.

" Edward Holmes, an evolutionary biologist at the University of Sydney who was not involved in the study, said: "When the new coronavirus was first discovered, its receptor binding domain looked special because there were too few viruses to compare
.

Holmes added: "Now we are sampling more from nature to discover these closely related gene sequences
.

Eventually, with more sampling, the natural ancestor of the entire new coronavirus genome will be revealed
.

" The researchers also It was found that none of the bat coronaviruses isolated in Laos contained furin cleavage sites in the spike protein
.

The authors believe that this may be due to insufficient sampling of bats, or the acquisition of a cleavage site in the transmission chain of the intermediate animal host, or it may be in the unreported population at the beginning of the virus outbreak, because the virus at that time may not have caused it.
What symptoms
.

In short, the results of the study pointed out the existence of a new bat virus Sarbecovirus
.

This virus seems to have the same potential to infect humans as the original strain of the new coronavirus
.

Maria van Kokhoff, head of technology for the World Health Organization's new crown epidemic, sent an email to tell Bloomberg: "This study is really meaningful, and we need more such studies
.

" At the same time, she is still tweeting.
I thanked the author for sharing this research with her before the official publication, and said that only through rigorous scientific cooperation, sharing of results, and more in-depth research, rather than politics, can we better understand the new coronavirus
.

Holmes said: "This study highlights the diversity of SARS-CoV-2-like viruses in Southeast Asian bats
.

Therefore, continuous sampling is the only way to understand the source of this virus, and it is important to conduct more sampling
.

This study emphasizes The bat coronavirus that may infect humans has always existed in nature and may appear at any time
.

This is an obvious risk in the future
.

”Link to the paper: https:// 2020 hot articles selection 1.
The cup is full! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
US, UK, Australia Scientists "Natural Medicine" add another proof: the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: The effect of intermittent fasting on health, aging and disease 4.
Healing insomnia within one year! Research found: improvement For sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: "touching and rolling in nature" "28 days, enough to improve immunity.
7.
Junk food is "really rubbish"! It takes away the length of telomeres and makes people grow old faster! 8.
Cell puzzle: not sleeping can really die! But lethal Changes do not occur in the brain, but in the intestines.
.
.
9.
"Nature Communications" ultra-large-scale study: the level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight.
Let the old brain regain its youth.
.
.