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Cell interpretation! Ticks that transmit Lyme disease may produce special antibiotics to protect them from human skin bacteria!
Time of Update: 2020-12-22
December 21, 2020 // -- In a recent study published in the international journal Cell entitled "Ticks resist skin commensals with immune factor of bacterial origin", scientists from the University of California and other institutions found that Lyme ticks may produce antibiotics to protect them from human skin bacteria.
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New drug for irritable bowel syndrome (IBS)! β-3 epinephrine-can-pertasive agitant vibegron to treat IBS-related abdominal pain phase 2 clinical failure!
Time of Update: 2020-12-21
This was a randomized, double-blind, placebo-controlled clinical trial in female patients with irritable bowel syndrome (IBS) abdominal pain accompanied by IBS-D (diarrhea) and IBS-M (mixed IBS) and assessed the efficacy and safety of vibegron (75 mg) once a day.
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The world's first treatment for gangrene sepsis (PG)! AbbVie's $20 billion annual Humira Japan is approved as the 12th adaptive disease!
Time of Update: 2020-12-21
November 29, 2020 // -- AbbVie and Eisai recently jointly announced that Humira (common name: adalimumab, Adamo single resistance) has been approved in Japan for a new adaptation to treat gangrenosum (pyoderma gangrenosum, PG).
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The study found that IGF2R regulates "proton re-pathways" that give macrophages anti-inflammatory potential
Time of Update: 2020-12-21
Wang Ying, a researcher at the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences, and Shi Yuxuan, a researcher at Science Advances, published a research paper online entitl
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J Hepatol: How a systemic inflammatory response exacerbates cirrhosis
Time of Update: 2020-12-21
In addition, experimental studies have shown that the intestinal wall barrier is weakened when cirrhosis occurs, so pathogenic bacteria and bacterial products can enter the bloodstream and cause chronic inflammatory reactions in the body, in other words," "systemic inflammation." All of these factors drive the development of liver disease, which can be clinically manifested as a shift from asymptomatic (reparation) cirrhosis to symptomatic (compensation) cirrhosis, which coexists with an increased risk of death.
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Immunity: Specific immune cells predict the severity of COVID-19
Time of Update: 2020-12-21
2, 2020 /--- According to a recent study published in the journal Immunity, in severe COVID-19 cases, not only do classical immune cells work, but the release of immature precellular cells from the bone marrow into the blood also indicates the severity of the disease and can lead to complications.
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Science: Reveals protein NRLP1 specific identification of double-stranded RNA to detect viral infection mechanisms
Time of Update: 2020-12-21
Nov 29, 2020 /--- In a new study, Veit Hornung of the University of Munich in Germany and his team confirmed that a protein found in skin cells called NRLP1 identifies specific nucleic acid intermediates formed during virus replication.
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A list of recent research advances in cell journal for the new coronavirus SARS-CoV-2/COVID-19 (No. 6)
Time of Update: 2020-12-21
results were published online November 14, 2020 in the journal Cell under the title "Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Complex Reveals an Intermediate State in Cap Synthesis." 5.Cell: Barrettinib reduces inflammation in rhesus monkeys infected with the new coronavirus: 10.1016/j.cell.2020.11.007SARS-CoV-2-induced hypercytokinemia (hypercytokinemia) and inflammation are closely related to the severity of COVID-19 disease.
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Proper diet and exercise may significantly reduce the body's risk of cardiovascular disease
Time of Update: 2020-12-21
Primary care clinicians can provide interventions for adults at risk of cardiovascular disease to help them have a healthy diet and exercise better, high blood pressure, high cholesterol and smoking are the risk factors, cardiovascular disease is the number one killer in the United States, and now we all know that if we can help people eat and exercise properly, we can prevent many cardiovascular disease events.
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New drug for psoriasis arthritis (PsA)! The Johnson and Johnson IL-23 inhibitor Tremfya (Tenoya ®) has been approved by the European Union and is listed in China!
Time of Update: 2020-12-21
November 28, 2020 // -- Johnson and Johnson (JNJ)'s Janssen Pharmaceuticals recently announced that the European Commission (EC) has approved Tremfya (Chinese product name: Tenoya ®, GM name : guselkumab, gusekumab), used to treat adult patients with active psoriasis arthritis (PsA) that is suitable for system therapy and who have received modified rheumatoid drugs (DMARD) for previously accepted diseases.
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The liver has immune function? Nature: The distribution of immune cells in the liver affects the body's immune status
Time of Update: 2020-12-20
effects of weaning on the distribution of dead cells in the liver of mice researchers used fluorescent staining, genetic disturbances, transcriptional histology and mathematical modeling to re-evaluate the relationship between the positioning of immune cells in the liver and host protection.
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Plos Pathogen: How can the vaginal microbiome prevent HIV infection?
Time of Update: 2020-12-20
Based on a study published December 3, 2020 in the journal PLOS Pathogens, Dr. Nicole Klatt of the University of Minnesota School of Medicine and colleagues found that this imbalance may lead to the metabolism of bacteria in drugs designed to prevent HIV infection, thereby reducing their effectiveness and increasing the risk to women.
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Nature: Fungal infection activates the host's inflammatory response mechanism
Time of Update: 2020-12-20
December 4, 2020 /--- In a recent study, scientists at st Jude Children's Research Hospital have identified the mechanism for the activation of inflammatory bodies caused by infections caused by the fungal pathogen nicosin.
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PRSB: What's new! Cancer cells may be able to spread more efficiently to their surroundings!
Time of Update: 2020-12-20
Unlike human health cells, cancer cells are thought to lose their ability to perceive things around them early in their progression, meaning they are better able to "blindfold" and focus on replicating and forming primary tumors, and for the first time in this paper, researchers have observed that some cancer cells can actually re-open that awareness and remove "eye masks" to effectively move to other parts of the body for proliferation.
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PNAS: The use of cells "iron death" may hopefully help develop new cancer therapies
Time of Update: 2020-12-20
researcher Jiang points out that this is the most significant tumor degeneration I have observed in the lab, and that the mutated PI3K-AKT-mTOR signaling path path may protect cancer cells from damage by increasing the activity of a protein involved in the production of extracellular lipids, which also protect cells from oxidative stress, thus preventing cell iron death, while blocking the PI3K-AKT-mTOR path path is able to prevent lipid synthesis and make cells sensitive to iron death again.
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Cell Metabol: Scientists have developed a new technology that can parse cellular energy code, promising to help improve the treatment of multiple cancers
Time of Update: 2020-12-20
the technique, called SCENITH, is a new method developed by researchers that can help identify the sources of energy that different cells in a tumor depend on and, more importantly, clarify the specific energy needs of immune cells in adverse environments (tumor micro-environments), which can be used as indicators of cellular energy status using levels of protein synthesis, which accounts for half of the cell's energy consumption.
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Science: Key proteins identify cold viruses
Time of Update: 2020-12-20
DECEMBER 3, 2020 /--- In a recent study, a team of scientists from Nanyang Technological University's Institute of Science, Technology and Research (A-STAR) in Singapore discovered the role of proteins in detecting common cold viruses and initiating an immune response to infection.
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PNAS: Key genes protect osteoarthritis from occurrence
Time of Update: 2020-12-20
, when researchers increased the level of FoxO1 molecules in mice with osteoarthritis, the cartilage damage in the animals decreased.
, the molecule interferes with cartilage damage and the development of arthritis by enhancing the process of autophagy in arthritis joints.
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BMJ Sub-Journal: Children's special immune systems and blood vessels reduce their risk of developing COVID-19
Time of Update: 2020-12-20
"We know that pre-existing vascular damage plays an important role in the severity of COVID-19 and can lead to blood clots, strokes and heart attacks." COVID-19 can infect these endosthel cells and cause inflammation of blood vessels.
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JAMA Network Open: Cancer rates are on the rise in adolescent groups
Time of Update: 2020-12-20
zaorsky, a researcher at the Pennsylvania State Cancer Institute, said the incidence of kidney, thyroid and gastrointestinal cancers is increasing in this age group.
further research is needed to determine why kidneys, thyroid, gastrointestinal and other types of cancer are on the rise in adolescents and young people, zaorsky said.
