Nature: Fungal infection activates the host's inflammatory response mechanism

December 4, 2020 /--- In a recent study, scientists at st Jude Children's Research Hospital have identified the mechanism for the activation of inflammatory bodies caused by infections caused by the fungal pathogen nicosin.
infections, especially aflatoxin, are the main cause of infection-related death in people with compromised immune systems.
this work provides clues to potential treatments for infectious and inflammatory diseases.
results were published online today in the journal Nature.
(Photo: www.pixabay.com) St Jude Immunology, one of the pioneers in the field of inflammatory small bodies, said: "Inflammatory small bodies are important outposts of the innate immune defense system of organisms.
previous studies have shown that fungal pathogens activate inflammatory small bodies, but the exact mechanism of action involving inflammatory small bodies is unclear.
to understand these mechanisms, scientists looked for molecular patterns associated with pathogens that stimulate innate immune responses by activating inflammatory small bodies.
scientists focused on the most inflammatory body sensorS NLRP3.
study identified semi-lactose amino semi-lactose (GAG), a molecular model associated with a new fungal pathogen.
GAG is essential for the activation of the NLRP3 inflammatory body induced by soot mold.
scientists have shown that the absence of GAG can not induce inflammatory body activation.
, excessive production of GAG increases the activation of inflammatory small bodies.
addition, the active body is essential to remove the infection of soot mold in animals.
strains that failed to produce GAG were more toxic in mice, while strains that produced GAG in excess were less toxic.
, in mouse models of colitis, an inflammatory disease, intestinal inflammation is protective during the inflammatory process.
treatment of purified GAG can prevent colitis.
"We have shown that protection against this inflammatory disease depends on the ability of GAG to induce inflammation in small bodies," said lead author Dr. Benoit Briard.
" are evidence of the mechanisms by which GAG has therapeutic potential in inflammatory diseases.
Bioon .com: Research reveals how a fungal actives actives original source: Briard, B., Fontaine, T., Samir, P. et al. Galactosaminogalactan activates the inflammasome to provide host protection. Nature (2020). doi.org/10.1038/s41586-020-2996-z。