J Hepatol: How a systemic inflammatory response exacerbates cirrhosis

December 2, 2020 // --- About 170,000 deaths are caused by cirrhosis in Europe each year, with the most recent epidemiological data showing that Austria ranks second in the prevalence of cirrhosis in Europe.
alcohol consumption, poor eating habits and metabolic adhesion are the most common causes of cirrhosis in the Western world.
liver cirrhosis is characterized by chronic liver damage, leading to liver fibrosis and loss of liver tissue function.
changes in the liver tissue lead to increased resistance to blood flow through the door veins to the liver and to so-called "door vein hypertension".
In addition, experimental studies have shown that the intestinal wall barrier is weakened when cirrhosis occurs, so pathogenic bacteria and bacterial products can enter the bloodstream and cause chronic inflammatory reactions in the body, in other words," "systemic inflammation."
All of these factors drive the development of liver disease, which can be clinically manifested as a shift from asymptomatic (reparation) cirrhosis to symptomatic (compensation) cirrhosis, which coexists with an increased risk of death.
a recent study by the University of Vienna School of Medicine.com, nearly 170 patients were measured for venous pressure and blood samples were taken to identify biomarkers of systemic inflammation. Thomas Reiberger, head of the
liver cirrhosis clinic and head of the Vienna Laboratory of Hepato-Hemodynamics at the University Hospital of Vienna, explains: "The measurement of valve pressure through liver venous catheterization is currently the gold standard for assessing the severity of the hypertension of the veins. New findings from the
study show that in patients with asymptomatic (compensation) cirrhosis, the severity of gate vein hypertension increased significantly, while the biomarkers of systemic inflammation increased significantly in the later stages of the disease (compensation).
interleton 6 is a biomarker of inflammation that can predict the complications and risk of death from reparation and non-compensation cirrhosis.
highlights the importance of systemic inflammation for cirrhosis," said Simbrunner, a researcher at the U.S. Government.
mechanisms for the development of inflammatory signals and the potential interaction between the intestine and the liver need to be further clarified.
the study has been published in the journal Journal of Hepatology.
(Bioon.com) Source: Study reveals the impact of systemic on disease progression Source: Dalila COSTA et al. Systemic inflammation increases across distinct stages of advanced chronic liver disease and correlates with decompensation and mortality, Journal of Hepatology (2020). DOI: 10.1016/j.jhep.2020.10.004。