The liver has immune function? Nature: The distribution of immune cells in the liver affects the body's immune status

The liver is made up of many hexa-shaped liver leaves, which are histologically delineated with E-calcium stick proteins.
because of one-way blood flow, there are gradients of oxygen, nutrients and hormones in the liver, and the interval distribution of some key enzymes, such as glutamine synthase, improves metabolic efficiency.
studies have shown that dead cells in the liver are found near the vein system.
, does the liver's immune system also have this interval distribution? Does this distribution have an effect on the body's immune system? On November 25, 2020, nature magazine published online the results of a study by researchers such as Ronald N. Germain and Anita Gola of the National Institutes of Health.
study found that symbly bacterial bacteria drive the liver's immune zoning and optimize host immune function.
, researchers found that dead cells at weaning were rich around the liver's peripheral regions, but this zoning did not exist in the livers of sterile mice.
this distribution caused by physiological changes during weaning? After the researchers fed adult sterile mice with adult mice without specific pathogens (SPF), adult sterile mice also developed cell-dead partitions.
the SPF mice with antibiotics, the veins of the dead cells disappeared.
effects of weaning on the distribution of dead cells in the liver of mice researchers used fluorescent staining, genetic disturbances, transcriptional histology and mathematical modeling to re-evaluate the relationship between the positioning of immune cells in the liver and host protection.
found that myelin and lymphatic-like resident immune cells were concentrated in the surrounding area.
This immune partition is not controlled by development, but is caused by the continuous MYD88-dependent signaling induced by symbient bacteria in the endothornic cells of the sinuses, which in turn regulates the composition of the surrounding substitins of the cells involved in the gradient formation of the chic factor.
, the researchers assessed the functional benefits of immune liver zoning to the host.
in vivo have shown that this immune space polarization is more effective than uniform distribution in preventing the spread of systemic bacteria.
, these data show that hepatocyte endothell cells can perceive the microbiome and actively coordinate the positioning of immune cells to optimize host defenses.
()