-
Nature Bai Fan/Huang Yanyi team and collaborators reveal somatic mutations in normal human tissues
Time of Update: 2021-09-03
Cells in various normal tissues in the human body are inevitably accumulating mutations . The occurrence of these somatic mutations is usually related to various types of DNA damage suffered during
-
How to live longer: diet is linked to "disease-free life expectancy" over 50
Time of Update: 2021-09-03
A study published in the American Journal of Clinical Nutrition aims to investigate the relationship between diet quality and life expectancy without cardiometabolic diseases between the ages of 50 and 85 .
For the participants with the healthiest diet, the number of years of life without cardiometabolic disease after the age of 50 was 23.
-
Your eyes reveal the risk of Alzheimer's disease
Time of Update: 2021-09-03
In a small cross-sectional study, a research team led by the University of California San Diego School of Medicine compared the A4 study and another study (longitudinal assessment of amyloid and neurodegeneration risk) in patients’ retina and brain amyloid levels , To assess the individual’s risk of neurodegeneration .
-
Chinese scholars have made new progress in the study of photoelectric catalytic total water decomposing hydrogen production
Time of Update: 2021-09-03
This work is based on the principle of natural photosynthesis, and successfully realized the high-efficiency photoelectric catalytic total water splitting process inspired by the Z mechanism of natural photosynthesis .
-
The University of Southern California Cell Journal tracks how the human kidney forms a filter unit
Time of Update: 2021-09-03
This study details the similar genetic mechanisms of human and mouse nephron formation, allowing other teams of scientists to follow the logic of these developmental procedures to create new types of kidney cells .
-
Study on the hypoglycemic activity of betulinic acid derivatives by humanized TGR5 mice
Time of Update: 2021-09-03
The bile acid receptor TGR5 (Takeda G protein-coupled receptor 5) plays an important role in blood glucose homeostasis, energy expenditure and liver protection. It is a potential drug target for the
-
How does cholesterol in the brain regulate ion channels and change their functions?
Time of Update: 2021-09-03
Stratton Professor of Neuroscience, Director of the Center for Neurotechnology and Behavior at Icahn School of Medicine at Mount Sinai, and senior author of the paper Through a structural and functional approach, researchers from the Icahn School of Medicine at Mount Sinai and Stanford University Medical Center determined the physical binding site of cholesterol in the g-protein-gated internal rectifier potassium (GIRK) channel of the brain.
-
PNAS: Cellular senescence associated with cancer caused by non-coding RNA
Time of Update: 2021-09-03
At the Japan Cancer Research Foundation (JFCR), scientists discovered that non-coding RNA (ncRNA) comes from repetitive elements around the center point, which can trigger inflammatory gene expression during aging and cancer .
-
Nature Sub-Journal: In-depth analysis of alcohol addiction through multi-omics methods
Time of Update: 2021-09-03
They used multi-omics methods to discover a large number of candidate genes related to drinking and alcohol use disorders .
Using data from these organizations, they fine-tuned the complex loci and identified possible mutations and candidate genes, including the SPI1 and MAPT genes related to alcoholism .
-
Changes in the two sirtuin enzymes can change mitochondrial dynamics and weaken heart contraction
Time of Update: 2021-09-03
In addition, researchers report that age-related SIRT1 and SIRT3 deficiency can damage heart function by altering mitochondrial dynamics, which play an important role in metabolic health and inflammation .
-
Research finds the enzyme that determines COVID-19 mortality or Long-COVID
Time of Update: 2021-09-03
"In this study, we were able to identify the patterns of metabolites present in the human body who died of this disease," said Justin Snider, the lead author of the study and an assistant research professor in the Department of Nutrition at the University of Arizona.
-
Peking University, Chinese Academy of Medical Sciences, etc. The latest Nature publication: The law of somatic mutations in normal human tissues
Time of Update: 2021-09-03
Cells in various normal tissues in the human body are inevitably accumulating mutations . The occurrence of these somatic mutations is usually related to various types of DNA damage suffered during
-
New technology, a new method of manipulating gene expression and studying genetic diseases
Time of Update: 2021-09-03
To solve this problem, Emma Andersson of the Department of Cellular and Molecular Biology and her team developed a method that can quickly remove or add genes in mice (days/weeks), focusing on the brain and spinal cord .
-
Reverse and reverse!
Time of Update: 2021-09-03
In a new paper, Lampson and his colleagues reveal the power of a balance in meiosis, which is the process of cell division that produces gametes, which allows a specific chromosome to enter a viable egg with a probability of close to 50%.
-
The discovery that TRPV4 gene regulates cartilage growth may provide future treatments for joint repair
Time of Update: 2021-09-03
This ability has prompted researchers to study the use of induced pluripotent stem cells (iPSCs), which can be generated directly from adult cells for the development of new therapies for disease modeling, regenerative medicine, and drug discovery .
-
Research progress on water depth remote sensing inversion
Time of Update: 2021-09-03
. Related research "Coupling multi- temporal Landsat-8 data and high spatial resolution satellite remote sensing data downscaled water depth inversion model: application verification from clean water to turbid water" was recently published in ISPRS Journal of Photogrammetry and Remote Sensing (" ISPRS International Journal of Photogrammetry and Remote Sensing) .
-
Molecular Cell: The first atomic-level imaging of deadly prions
Time of Update: 2021-09-03
Source: Case Western Reserve University/National Institute of Health and DevelopmentThe highest-resolution imaging of infectious prions ever provides the first atomic-level data on how these abnormal proteins assemble in humans and animals to cause deadly neurodegenerative diseases, and how they may become new treatments Goal .
-
The pressure brought about by the increase in the population may lead to a decline in the human fertility rate
Time of Update: 2021-09-03
Researchers predict that 2064 will be the peak of the population. By the end of this century, due to changes in human reproductive behavior and functions, the population will drop by 50% . In the p
-
Chinese scholars and overseas collaborators have made progress in the research of polymer surface microdynamics mechanism
Time of Update: 2021-09-03
Figure 1 (a) Schematic diagram of the depth distribution of surface molecular motion ability and polymer chain conformation; (b) Creep relaxation behavior of the surface of polymer with small entanglement molecular weight at different temperatures Supported by the National Natural Science Foundation of China (approval numbers: 21973083, 21504081, 21674100, 21873085), Professor Zuo Biao of Zhejiang Sci-Tech University and foreign collaborators Rodney Priestley and David Simmons have conducted research on the molecular dynamics mechanism of glassy polymer surfaces.
-
High cholesterol promotes cancer by enhancing resistance to certain cell death
Time of Update: 2021-09-03
Now a research team led by the Cancer Institute of Duke University has determined the working mechanism, describing how breast cancer cells use cholesterol to develop stress resistance, so that they will not die because they migrate from the original tumor site .
